Cited by 92Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal and reproductive studies

Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. A nationwide register study

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Thvilum, Marianne, Brandt, Frans, Almind, Dorthe, Christensen, Kaare, Brix, Thomas Heiberg, Hegedüs, Laszlo·2013·PLoS ONE

Abstract

BACKGROUND: Hypothyroidism has been linked with an increased risk of other morbidities, such as cardiovascular diseases and diabetes mellitus. However, the temporal relationship between these diseases and the diagnosis of hypothyroidism is not well illuminated. Such information may provide insight into causal relationships between hypothyroidism and other morbidities. AIM: To investigate the type and extent of somatic morbidity before and after a diagnosis of hypothyroidism. METHODS: Observational cohort study. From official Danish health registers, 2822 hypothyroid singletons were identified and matched 1:4 with non-hypothyroid controls and observed over a mean period of 6 years. Frequency of different morbidities was obtained by person-to-person linking in the registers. Logistic and Cox regression models were used to assess the risk of morbidity before and after the diagnosis of hypothyroidism, respectively. RESULTS: Prior to the diagnosis of hypothyroidism there was a significantly increased risk of being diagnosed with cardiovascular diseases (odds ratio (OR) 1.37; 95% confidence interval (CI): 1.19-1.58), lung diseases (OR 1.25; 95% CI: 1.13-1.39), diabetes mellitus (OR 1.92; 95% CI: 1.61-2.29), as well as malignant diseases (OR 1.24; 95% CI: 1.06-1.45). Following the diagnosis of hypothyroidism there was a significantly increased risk of being diagnosed with cardiovascular diseases (hazard ratio (HR) 1.36; 95% CI: 1.15-1.60); lung diseases (HR 1.51; 95% CI: 1.30-1.75); and diabetes mellitus (HR 1.40; 95% CI: 1.11-1.77). CONCLUSIONS: Prior to the diagnosis of hypothyroidism there is an excess risk of being diagnosed with cardiovascular diseases, lung diseases, diabetes mellitus, and malignant diseases. Following the diagnosis of hypothyroidism we demonstrate an increased frequency of cardiovascular diseases, lung diseases, and diabetes mellitus.

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  1. [40]Díez JJ, Sánchez P, Iglesias P (2011) Prevalence of thyroid dysfunction in patients with type 2 diabetes. Exp Clin Endocrinol Diabetes 199: 201– 207. 21465427
  2. [41]Perros P, McCrimmon RJ, Shaw G, Frier BM (1995) Frequency of thyroid dysfunction in diabetic patients: value of annual screening. Diabet 12: 622– 627. 7554786

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Authors
Thvilum, M., Brandt, F., Almind, D., Christensen, K., Brix, T. H., & Hegedüs, L.
Affiliations
  • Odense University Hospital (DK)
  • University of Southern Denmark (DK)
Venue
PLoS ONE
Published
2013-09-16
Volume
8
Issue
9
Pages
e75789
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2089986314
Cited by
92
References
45
Citations by year
2025: 6 · 2024: 8 · 2023: 8 · 2022: 13 · 2021: 17 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 8 · 2013: 1
FWCI
4.72
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Novo Nordisk
  • Syddansk Universitet
  • Novo Nordisk Fonden
  • National Institute on Aging (P01AG008761, P01-AG08761)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
hypothyroidism, somatic morbidity, cardiovascular disease, lung disease, diabetes mellitus, cancer, comorbidities, thyroid dysfunction
MeSH terms
Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Hypothyroidism, Male, Middle Aged, Twins

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