CoChat
Sign Up
Cited by 46Growth Hormone and Insulin-like Growth FactorsHormonal and reproductive studiesHypothalamic control of reproductive hormones

Determinants of IGF1 and GH across the weight spectrum: from anorexia nervosa to obesity

Open access
Brick, D J, Gerweck, A V, Meenaghan, E, Lawson, E A, Misra, M, Fazeli, P, Johnson, W, Klibanski, A +1 more·2010·European Journal of Endocrinology
DOI 10.1530/eje-10-0365PMC PMC2953770
Open this paper in CoChat — free account

Abstract

Context: Chronic starvation is characterized by GH resistance, and obesity is characterized by decreased GH secretion. In both extremes, IGF1 levels may be low and androgen levels may be abnormal. Objective: To investigate the determinants of IGF1 and GH across the weight spectrum in women. Design: Cross-sectional study. Setting: Clinical research center. Study participants: In total, 32 women had participated in the study: 11 women with anorexia nervosa (AN), 11 normal-weight women, and 10 obese women of comparable mean age. Intervention: None. Main outcome measures: Pooled hourly overnight serum samples assayed for IGF1, GH, estradiol (E 2), testosterone, SHBG, insulin, free fatty acids, and trunk fat. Results: Free testosterone was higher in obese women and lower in women with AN than in normal-weight women, and was the only independent (and positive) predictor of IGF1 levels, accounting for 14% of the variability (P=0.032) in the group as a whole. This relationship was stronger when obese women were excluded, with free testosterone accounting for 36% of the variability (P=0.003). Trunk fat accounted for 49% of the variability (P<0.0001) of GH, with an additional 7% of the variability attributable to E 2 (P=0.042) in the group as a whole, but was not a significant determinant of GH secretion when obese women were excluded. Conclusions: Free testosterone is a significant determinant of IGF1 levels in women across the body weight spectrum. In contrast, GH secretion is differentially regulated at the extremes of the weight spectrum.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1530/eje-10-0365

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Brick, D. J., Gerweck, A. V., Meenaghan, E., Lawson, E. A., Misra, M., Fazeli, P., Johnson, W., Klibanski, A., & Miller, K. K.
Affiliations
Harvard University (US)
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2010-08
Volume
163
Issue
2
Pages
185-191
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje-10-0365
PMC
PMC2953770
OpenAlex
W2165655868
Cited by
46
References
31
Citations by year
2023: 2 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 1 · 2013: 4 · 2012: 5
FWCI
2.65
Type
journal article
Language
en
Open access
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Massachusetts General Hospital
  • National Heart, Lung, and Blood Institute (K24HL092902, R01HL077674)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK52525, P30DK040561)
  • National Center for Research Resources (UL1RR025758, M01RR001066, M01-RR01066)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
insulin-like growth factor I, growth hormone, anorexia nervosa, obesity, body weight, free testosterone, estradiol, trunk fat, sex hormone-binding globulin, insulin, androgens, women
MeSH terms
Adipose Tissue, Adolescent, Anorexia Nervosa, Body Composition, Body Weight, Cross-Sectional Studies, Estradiol, Fatty Acids, Nonesterified, Female, Humans, Insulin, Insulin-Like Growth Factor I, Middle Aged, Obesity, Radioimmunoassay, Sex Hormone-Binding Globulin, Testosterone, Body Mass Index, Human Growth Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review