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RBP4: a controversial adipokine
Abstract
Adipose tissue is an endocrine organ secreting biologically active factors called adipokines that act on both local and distant tissues. Adipokines have an important role in the development of obesity-related comorbidities not only in adults but also in children and adolescents. Retinol binding protein 4 (RBP4) is a recently identified adipokine suggested to link obesity with its comorbidities, especially insulin resistance, type 2 diabetes (T2D), and certain components of the metabolic syndrome. However, data, especially resulting from the clinical studies, are conflicting. In this review, we summarize up-to-date knowledge on RBP4's role in obesity, development of insulin resistance, and T2D. Special attention is given to studies on children and adolescents. We also discuss the role of possible confounding factors that should be taken into account when critically evaluating published studies or planning new studies on this exciting adipokine.
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“Some LCN family members, including major urinary protein 1, retinol-binding protein 4, LCN2, and LCN13, have been shown to regulate energy metabolism [[254], [255], [256]].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [256]
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Metadata
- Authors
- Kotnik, P., Fischer-Posovszky, P., & Wabitsch, M.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Wabitsch, Martin
- ORCID
- Wabitsch, Martin
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11
- Volume
- 165
- Issue
- 5
- Pages
- 703-711
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2133792826
- Cited by
- 233
- References
- 94
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 11 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 11 · 2016: 23 · 2015: 28 · 2014: 28 · 2013: 26 · 2012: 19
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- retinol-binding protein 4, adipokines, obesity, insulin resistance, type 2 diabetes, metabolic syndrome, childhood obesity, adolescent obesity, obesity-related comorbidities, confounding factors
- MeSH terms
- Adipose Tissue, Animals, Clinical Trials as Topic, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Obesity, Adipokines, Retinol-Binding Proteins, Plasma
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