Cited by 234Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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RBP4: a controversial adipokine

Kotnik, Primoz, Fischer-Posovszky, Pamela, Wabitsch, Martin·2011·European Journal of Endocrinology

DOI 10.1530/eje-11-0431

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Abstract

Adipose tissue is an endocrine organ secreting biologically active factors called adipokines that act on both local and distant tissues. Adipokines have an important role in the development of obesity-related comorbidities not only in adults but also in children and adolescents. Retinol binding protein 4 (RBP4) is a recently identified adipokine suggested to link obesity with its comorbidities, especially insulin resistance, type 2 diabetes (T2D), and certain components of the metabolic syndrome. However, data, especially resulting from the clinical studies, are conflicting. In this review, we summarize up-to-date knowledge on RBP4's role in obesity, development of insulin resistance, and T2D. Special attention is given to studies on children and adolescents. We also discuss the role of possible confounding factors that should be taken into account when critically evaluating published studies or planning new studies on this exciting adipokine.

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Authors: Kotnik, P., Fischer-Posovszky, P., & Wabitsch, M.
Affiliations: Universität Ulm (DE)
Corresponding author: Wabitsch, Martin
ORCID: Wabitsch, Martin
Venue: European Journal of Endocrinology
Publisher: Oxford University Press (OUP)
Published: 2011-11
Volume: 165
Issue: 5
Pages: 703-711
ISSN: 0804-4643 (ISSN-L)
1479-683X
DOI: 10.1530/eje-11-0431
OpenAlex: W2133792826
Cited by: 233
References: 94
Citations by year: 2026: 3 · 2025: 4 · 2024: 8 · 2023: 11 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 11 · 2016: 23 · 2015: 28 · 2014: 28 · 2013: 26 · 2012: 19
FWCI: 2.77
Type: journal article
Language: en
Open access: closed
Locations: European Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: retinol-binding protein 4, adipokines, obesity, insulin resistance, type 2 diabetes, metabolic syndrome, childhood obesity, adolescent obesity, obesity-related comorbidities, confounding factors
MeSH terms: Adipose Tissue, Animals, Clinical Trials as Topic, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Obesity, Adipokines, Retinol-Binding Proteins, Plasma

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