Failure to increase insulin secretory capacity during pregnancy-induced insulin resistance is associated with ethnicity and gestational diabetes
Open accessAbstract
Objective: To assess changes in insulin resistance and β-cell function in a multiethnic cohort of women in Oslo, Norway, from early to 28 weeks' gestation and 3 months post partum and relate the findings to gestational diabetes mellitus (GDM). Method: Population-based cohort study of 695 healthy pregnant women from Western Europe (41%), South Asia (25%), Middle East (15%), East Asia (6%) and elsewhere (13%). Blood samples and demographics were recorded at mean 15 (V1) and 28 (V2) weeks' gestation and 3 months post partum(V3). Universal screening was by 75 g oral glucose tolerance test at V2, GDM with modified IADPSG criteria (no 1-h measurement): fasting plasma glucose (PG) ≥5.1 or 2-h PG ≥8.5 mmol/l. Homeostatic model assessment (HOMA)-β (β-cell function) and HOMA-IR (insulin resistance) were calculated from fasting glucose and C-peptide. Result: Characteristics were comparable across ethnic groups, except age (South Asians: younger,P<0.001) and prepregnant BMI (East Asians: lower,P=0.040). East and South Asians were more insulin resistant than Western Europeans at V1. From V1 to V2, the increase in insulin resistance was similar across the ethnic groups, but the increase in β-cell function was significantly lower for the East and South Asians compared with Western Europeans. GDM women compared with non-GDM women were more insulin resistant at V1; from V1 to V2, their β-cell function increased significantly less and the percentage increase in β-cell function did not match the change in insulin resistance. Conclusion: Pregnant women from East Asia and South Asia were more insulin resistant and showed poorer HOMA-β-cell function than Western Europeans.
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Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Hyperglycemia and adverse pregnancy outcomes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707943 · Cited by 5,563 · see citing works
International Association of Diabetes and Pregnancy Study Groups Consensus Panel (2010) · Diabetes Care · doi:10.2337/dc09-1848 · Cited by 5,390 · see citing works
Use and Abuse of HOMA Modeling
Wallace, T. M., Levy, J. C., & Matthews, D. R. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1487 · Cited by 5,114 · see citing works
Type 2 diabetes across generations: from pathophysiology to prevention and management
Nolan, C. J., Damm, P., & Prentki, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60614-4 · Cited by 923 · see citing works
The assessment of insulin resistance in man
Wallace, T. M., & Matthews, D. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00745.x · Cited by 691 · see citing works
Sacks, D. A., Hadden, D. R., Maresh, M., Deerochanawong, C., Dyer, A. R., Metzger, B. E., Lowe, L. P., Coustan, D. R., Hod, M., Oats, J. J. N., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1641 · Cited by 687 · see citing works
Obesity-related non-communicable diseases: South Asians vs White Caucasians
Misra, A., & Khurana, L. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.135 · Cited by 491 · see citing works
Hyperglycemia and Adverse Pregnancy Outcomes
Metzger, B. E., Lowe, L. P., Dyer, A. R., Trimble, E. R., Chaovarindr, U., Coustan, D. R., Hadden, D. R., McCance, D. R., Hod, M., McIntyre, H. D., et al. (2009) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000344706.95925.dc · Cited by 479 · see citing works
Obesity, insulin resistance, and pregnancy outcome
Catalano, P. M. (2010) · Reproduction · doi:10.1530/rep-10-0088 · Cited by 446 · see citing works
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
Butler, A. E., Cao-Minh, L., Galasso, R., Rizza, R. A., Corradin, A., Cobelli, C., & Butler, P. C. (2010) · Diabetologia · doi:10.1007/s00125-010-1809-6 · Cited by 435 · see citing works
Buchanan, T. A., Xiang, A., Kjos, S. L., & Watanabe, R. (2007) · Diabetes Care · doi:10.2337/dc07-s201 · Cited by 417 · see citing works
Wulan, S. N., Westerterp, K. R., & Plasqui, G. (2010) · Maturitas · doi:10.1016/j.maturitas.2009.12.012 · Cited by 353 · see citing works
Gestational diabetes mellitus: results from a survey of country prevalence and practices
Jiwani, A. Z., Marseille, E. A., Lohse, N., Damm, P., Hod, M., & Kahn, J. G. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2011.587921 · Cited by 318 · see citing works
Palei, P., & Rajesh, U. (2023) · Springer eBooks · doi:10.1007/978-3-031-24465-0_20 · Cited by 310 · see citing works
Jenum, A. K., Mørkrid, K., Sletner, L., Vange, S., Torper, J. L., Nakstad, B., Voldner, N., Rognerud-Jensen, O. H., Berntsen, S., Mosdøl, A., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0866 · Cited by 288 · see citing works
Self-citationA MORPHOLOGICAL STUDY OF THE ENDOCRINE PANCREAS IN HUMAN PREGNANCY
Van Assche, F. A., Aerts, L., & Prins, F. D. (1978) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1978.tb15835.x · Cited by 267 · see citing works
Færch, K., Borch‐Johnsen, K., Holst, J. J., & Vaag, A. A. (2009) · Diabetologia · doi:10.1007/s00125-009-1443-3 · Cited by 255 · see citing works
Dickinson, S. P., Colagiuri, S., Petocz, P., Brand-Miller, J. C., & Faramus, E. (2002) · Journal of Nutrition · doi:10.1093/jn/132.9.2574 · Cited by 201 · see citing works
The Potential Diabetic and Her Treatment in Pregnancy
O’Sullivan, J. B., Gellis, S. S., Dandrow, R. V., & Tenney, B. (2003) · Obstetrics and Gynecology · doi:10.1097/00006250-200307000-00004 · Cited by 175 · see citing works
Metabolic syndrome and cardiovascular disease in South Asians
Merchant, N. (2009) · Vascular Health and Risk Management · doi:10.2147/vhrm.s5172 · Cited by 144 · see citing works
Distinct β-Cell Defects in Impaired Fasting Glucose and Impaired Glucose Tolerance
Kanat, M., Mari, A., Norton, L., Winnier, D., DeFronzo, R. A., Jenkinson, C., & Abdul-Ghani, M. A. (2012) · Diabetes · doi:10.2337/db11-0995 · Cited by 122 · see citing works
Mechanisms in the adaptation of maternal β-cells during pregnancy
Ernst, S., Demirci, C., Valle, S. R., Velázquez-García, S., & Garcı́a-Ocaña, A. (2011) · Diabetes Management · doi:10.2217/dmt.10.24 · Cited by 111 · see citing works
Retnakaran, R. R., Qi, Y., Connelly, P. W., Sermer, M., Hanley, A. J., & Zinman, B. (2009) · Diabetologia · doi:10.1007/s00125-009-1600-8 · Cited by 111 · see citing works
Jenum, A. K., Sletner, L., Voldner, N., Vangen, S., Mørkrid, K., Andersen, L. F., Nakstad, B., Skrivarhaug, T., Rognerud-Jensen, O. H., Roald, B., et al. (2010) · Scandinavian Journal of Public Health · doi:10.1177/1403494810378921 · Cited by 106 · see citing works
Self-citationJenum, A. K., Diep, L. M., Holmboe‐Ottesen, G., Holme, I., Kumar, B., & Birkeland, K. I. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-150 · Cited by 99 · see citing works
Self-citationRetnakaran, R. R., Hanley, A. J., Connelly, P. W., Sermer, M., & Zinman, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1253 · Cited by 78 · see citing works
Radaelli, T., Farrell, K. A., Huston-Presley, L., Amini, S. B., Kirwan, J. P., McIntyre, D. H., & Catalano, P. M. (2009) · Diabetes Care · doi:10.2337/dc09-1463 · Cited by 78 · see citing works
Gestational diabetes guidelines in a HAPO world
Leary, J., Pettitt, D. J., & Jovanovič, L. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.05.009 · Cited by 69 · see citing works
Gestational diabetes mellitus in five ethnic groups: a comparison of their clinical characteristics
Wong, V. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03439.x · Cited by 60 · see citing works
Gunton, J. E., Hitchman, R., & McElduff, A. (2001) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2001.tb01205.x · Cited by 48 · see citing works
Low Serum Levels of High–Molecular Weight Adiponectin in Indo-Asian Women During Pregnancy
Retnakaran, R. R., Hanley, A. J., Connelly, P. W., Maguire, G. F., Sermer, M., & Zinman, B. (2006) · Diabetes Care · doi:10.2337/dc06-0413 · Cited by 38 · see citing works
Retnakaran, R. R., Qi, Y., Ye, C., Hanley, A. J., Connelly, P. W., Sermer, M., & Zinman, B. (2011) · Diabetes Care · doi:10.2337/dc11-0817 · Cited by 28 · see citing works
Gestational diabetes: evolving diagnostic criteria
Paglia, M. J., & Coustan, D. R. (2010) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e328342d21e · Cited by 18 · see citing works
Miyakoshi, K., Saisho, Y., Tanaka, M., et al. (2010) · Diabetes Care · doi:10.2337/dc10-1725 · Cited by 9 · see citing works
Alberti (1998) · doi:10.1002/(sici)1096-9136(199807)15:7
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Al-Badri, M. R., Zantout, M. S., & Azar, S. T. (2015) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018815577039 · Cited by 71 · see citing works
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Ignell, C., Shaat, N., Ekelund, M., & Berntorp, K. (2013) · Acta Diabetologica · doi:10.1007/s00592-013-0484-8 · Cited by 30 · see citing works
Behboudi-Gandevani, S., Ramezani Tehrani, F., Rahmati, M., Amiri, M., & Azizi, F. (2019) · BMC Endocrine Disorders · doi:10.1186/s12902-019-0348-5 · Cited by 14 · see citing works
- Authors
- Mørkrid, K., Jenum, A. K., Sletner, L., Vårdal, M. H., Waage, C. W., Nakstad, B., Vangen, S., & Birkeland, K. I.
- Affiliations
- Oslo University Hospital (NO)
- OsloMet – Oslo Metropolitan University (NO)
- University of Oslo (NO)
- Corresponding author
- Mørkrid, Kjersti
- ORCID
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-10
- Volume
- 167
- Issue
- 4
- Pages
- 579-588
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2128595507
- Cited by
- 83
- References
- 36
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 11 · 2012: 2
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Funders
- Norges Forskningsråd
- Helse Sør-Øst RHF
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- gestational diabetes mellitus, insulin resistance, beta-cell function, insulin secretion, ethnicity, South Asian women, East Asian women, HOMA-β, HOMA-IR, pregnancy, postpartum period, prepregnancy BMI
- MeSH terms
- Insulin Secretion, Adult, Ethnicity, Female, Follow-Up Studies, Geography, Humans, Insulin, Insulin Resistance, Pregnancy, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Cohort Studies, Diabetes, Gestational, Postpartum Period, Young Adult
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