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Cited by 54Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

The Effect of Chronic Treatment With GH on Gonadal Function in Men With Isolated GH Deficiency

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Carani, C, Granata, AR, De Rosa, M, Garau, C, Zarrilli, S, Paesano, L, Colao, A, Marrama, P +1 more·1999·European Journal of Endocrinology
DOI 10.1530/eje.0.1400224
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Abstract

Eleven adult males, previously submitted to neurosurgery because of a pituitary lesion (three with craniopharyngioma, three with clinically non-functioning adenoma and five with macroprolactinoma) were treated with recombinant GH for 12 months after the diagnosis of GH deficiency was made. Circulating FSH, LH, prolactin, testosterone, 17 beta-estradiol (E2), dehyroepiandrosterone (DHEA-S), androstenedione. 17-OH-progesterone (17OHP), IFG-I, and steroid hormone-binding protein (SHBG) levels were assayed before and after CG test at study entry and 6 and 12 months after GH treatment. A significant increase in plasma IGF-I levels was obtained after 6 and 12 months of GH treatment. In addition, CG-stimulated, but not baseline, testosterone levels showed a significant increase after 6 and 12 months of GH treatment when compared with study entry (9.6 +/- 0.5 and 9.9 +/- 0.5 vs 7.9 +/- 0.5 ng/ml; P < 0.05). Baseline, but not CG-stimulated, serum 17OHP levels were significantly increased only after 12 months of GH treatment (1.7 +/- 0.1 vs 1.4 +/- 0.1 ng/ml; P < 0.05). No significant difference was found as far as both basal and CG-stimulated E2, androstenedione, DHEA-S and SHBG were concerned. With regards to the semen analysis, only seminal plasma volume was significantly increased after 12 months of GH treatment (2.9 +/- 0.3 vs 1.7 +/- 0.3 ml; P < 0.05). No significant change in sperm count, motility and abnormal forms was observed. These data show that GH treatment displays a clear-cut effect upon Leydig cell function and increases the production of seminal plasma volume in fertile adult males with isolated GH deficiency.

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Authors
Carani, C., Granata, A., De Rosa, M., Garau, C., Zarrilli, S., Paesano, L., Colao, A., Marrama, P., & Lombardi, G.
Affiliations
  • University of Modena and Reggio Emilia (IT)
  • Federico II University Hospital (IT)
Corresponding author
Lombardi, G
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
1999-03-01
Volume
140
Issue
3
Pages
224-230
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje.0.1400224
OpenAlex
W2157252436
Cited by
54
References
32
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 4
FWCI
1.62
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
growth hormone deficiency, recombinant human growth hormone therapy, gonadal function, Leydig cell function, testosterone, insulin-like growth factor I, semen analysis, pituitary lesions, craniopharyngioma, prolactinoma, non-functioning pituitary adenoma
MeSH terms
Adult, Androstenedione, Dehydroepiandrosterone, Estradiol, Follicle Stimulating Hormone, Chorionic Gonadotropin, Humans, Insulin-Like Growth Factor I, Luteinizing Hormone, Male, Middle Aged, Prolactin, Prospective Studies, Radioimmunoassay, Sex Hormone-Binding Globulin, Growth Hormone, Spermatogenesis, Testosterone, Fluoroimmunoassay, 17-alpha-Hydroxyprogesterone, Human Growth Hormone

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