Molecular analysis of CDKN1C and TP53 in sporadic adrenal tumors
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OBJECTIVE: To evaluate the roles of the CDKN1C (P57KIP2) gene, which encodes for the cyclin-dependent kinase inhibitor CDNC, and the TP53 tumor suppressor gene in adrenal tumorigenesis, as a means of investigating the molecular basis of sporadic adrenal tumors, which is unknown. DESIGN: Screening for the presence CDKN1C and TP53 mutations and analyzing the expression pattern of CDNC, P53 and its downstream effector CDN1 (P21WAF1/CIP1) in a series of 79 sporadic adrenal tumors. METHODS: Single-strand conformation polymorphism and sequencing were used for mutation analysis of CDKN1C and TP53 in blood and adrenal tissue samples. In a subgroup of 48 tissues, CDKN1C expression was evaluated by RT-PCR and immunohistochemistry. Immunohistochemical analysis of P53 and CDN1 was performed. RESULTS: No somatic mutations of CDKN1C were found in the tumors analyzed, in spite of low/absent CDNC expression in adrenocortical adenomas and carcinomas. Mutations in the TP53 gene were present in 70% of adrenocortical carcinomas, associated with abnormal P53 and CDN1 expression, but not in benign neoplasms. In the normal adrenal cortex, CDNC expression was strictly nuclear and confined to the cortical zone (i.e. zona glomerulosa and reticularis), with no staining in the medulla. CONCLUSIONS: Mutations in the TP53 gene are frequent in adrenocortical carcinomas and might be used as a marker of malignancy. In the normal adrenal cortex, the zone-specific pattern of expression of CDNC suggests a role in adrenal differentiation.
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TP53 is the most commonly mutated gene in ACC, present in at least one-third of ACCs.
“TP53 located on 17p13 is the most commonly mutated gene in ACC, present in at least one-third of ACCs (140, 142, 202).”
From Adrenocortical carcinoma (2014) · cites this paper as [202]
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Zhang, P., Liégeois, N. J., Wong, C., Finegold, M. J., Hou, H., Thompson, J. C., Silverman, A., Harper, J. W., DePinho, R. A., & Elledge, S. J. (1997) · Nature · doi:10.1038/387151a0 · Cited by 750 · see citing works
Macfarlane, D. A. (1958) · PubMed · Cited by 266 · see citing works
Risk Factors and Long-Term Follow-Up of Adrenal Incidentalomas1
Barzon, L., Scaroni, C. M., Sonino, N., Fallo, F., Paoletta, A., & Boscaro, M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5444 · Cited by 255 · see citing works
p53 mutations in human adrenocortical neoplasms: immunohistochemical and molecular studies
Reincke, M., Karl, M., Travis, W. H., Mastorakos, G. P., Allolio, B., Linehan, H. M., & Chrousos, G. P. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.3.8126158 · Cited by 228 · see citing works
Casey, G., Me, L., Jc, R., Sj, P., Arboleda, M. J., Shaughnessy, M., Karlan, B. Y., & Dj, S. (1996) · PubMed · Cited by 205 · see citing works
Incidentally Discovered Adrenal Tumors: Endocrine and Scintigraphic Correlates1
Barzon, L., Scaroni, C. M., Sonino, N., Fallo, F., Gregianin, M., Macrì, C., & Boscaro, M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.1.4501 · Cited by 184 · see citing works
Chilosi, M., Piazzola, E., Lestani, M., Benedetti, A., Guasparri, I., Granchelli, G., Aldovini, D., Leonardi, E., Pizzolo, G., Doglioni, C., et al. (1998) · PubMed · Cited by 141 · see citing works
<i>p53</i> Mutations in sporadic adrenocortical tumors
Ohgaki, H., Kleihues, P., & Heitz, P. U. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910540310 · Cited by 139 · see citing works
O’Keefe, D., Dao, D., Zhao, L., Sanderson, R., Warburton, D., Weiss, L. M., Anyane‐Yeboa, K., & Tycko, B. (1997) · The American Journal of Human Genetics · doi:10.1086/514854 · Cited by 135 · see citing works
Clonal composition of human adrenocortical neoplasms.
Beuschlein, F., Reincke, M., Karl, M., Travis, W. D., Jaursch-Hancke, C., Abdelhamid, S., Chrousos, G. P., & Allolio, B. (1994) · PubMed · Cited by 129 · see citing works
Palmqvist, R., Stenling, R., �berg, �., & Landberg, G. (1999) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199905)188:1 · Cited by 100 · see citing works
Urano, T., Yashiroda, H., Muraoka, M., Tanaka, K., Hosoi, T., Inoue, S., Ouchi, Y., Tanaka, K., & Toyoshima, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12197 · Cited by 84 · see citing works
Cell proliferation and apoptosis in normal and pathologic human adrenal.
Sasano, H., Imatani, A., Shizawa, S., Suzuki, T., & Nagura, H. (1995) · PubMed · Cited by 83 · see citing works
Chilosi, M., Doglioni, C., Magalini, A. R., Inghirami, G., Krampera, M., Nadali, G., Rahal, D., Pedron, S., Benedetti, A., Scardoni, M., et al. (1996) · Blood · doi:10.1182/blood.v88.10.4012.bloodjournal88104012 · Cited by 68 · see citing works
Bourcigaux, N., Gaston, V., Logié, A., BERTAGNA, X. Y., Bouc, Y. L., & Gicquel, C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6303 · Cited by 57 · see citing works
Gicquel, C., Bertherat, J. Y., Bouc, Y. L., & BERTAGNA, X. Y. (2000) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70112-2 · Cited by 53 · see citing works
Edgren, M., Eriksson, B., Wilander, E., Westlin, J.-E., Nilsson, S. F., & Öberg, K. (1997) · PubMed · Cited by 50 · see citing works
Differential regulation of apoptosis in the normal human adrenal gland
Wolkersdörfer, G. W., Ehrhart‐Bornstein, M., Brauer, S., Marx, C., Scherbaum, W. A., & Bornstein, S. R. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923871 · Cited by 46 · see citing works
The relatively high frequency of p53 gene mutations in multiple and malignant phaeochromocytomas
Yoshimoto, T., Naruse, M., Zeng, Z., Nishikawa, T., Kasajima, T., Toma, H., Yamamori, S., Matsumoto, H., Tanabe, A., Naruse, K., et al. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1590247 · Cited by 40 · see citing works
Molecular and immunohistochemical analysis of P53 in phaeochromocytoma
Dahia, P., Aguiar, R., Tsanaclis, A. M. C., Bendit, I., Bydlowski, S. P., Abelin, N. M. A., & Toledo, S. P. A. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.487 · Cited by 31 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Barzon L, Scaroni C, Sonino N, Fallo F, Gregianin M, Macrõ Á C et al. Incidentally discovered adrenal tumors: endocrine and scinti- graphic correlates. Journal of Clinical Endocrinology and Metabo- lism 1998 83 55±62.
- Liu J, Kahri AI, Heikkila P & Voutilainen R. Ribonucleic acid expression of the clustered imprinted genes, p57KIP2, IGF-II, and H19, in adrenal tumors and cultured adrenal cells. Journal of Clinical Endocrinology and Metabolism 1997 82 1766±1771.
- Gicquel C, Raf®n-Sanson M, Gaston V, Bertagna X, Plouin P, Schlumberger M et al. Structural and functioning abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors. Journal of Clinical Endocrinology and Metabolism 1997 82 2559±2565.
- Lin S, Lee Y & Tsai J. Mutations of the p53 gene in human functioning adrenal neoplasms. Journal of Clinical Endocrinology and Metabolism 1994 78 483±491.
- de Krijger RR, van der Harst E, van der Ham F, Stijnen T, Dinjens WN, Koper JW et al. Prognostic value of p53, bcl-2, and c-erbB-2 protein expression in phaeochromocytomas. Journal of Pathology 1999 188 51±55.
Cited by
Sorted by citations
Else, T., Kim, A. C., Sabolch, A., Raymond, V. M., Kandathil, A., Caoili, E. M., Jolly, S., Miller, B. S., Giordano, T. J., & Hammer, G. D. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1029 · Cited by 892 · see citing works
Adrenocortical cancer: pathophysiology and clinical management
Libé, R., Fratticci, A., & Bertherat, J. Y. (2007) · Endocrine Related Cancer · doi:10.1677/erc.1.01130 · Cited by 271 · see citing works
Management of adrenocortical carcinoma
Allolio, B., Hahner, S., Weismann, D., & Fassnacht, M. (2004) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01881.x · Cited by 214 · see citing works
The molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors
Koch, C. A., Pacak, K., & Chrousos, G. P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021069 · Cited by 177 · see citing works
Molecular genetics of adrenocortical tumours, from familial to sporadic diseases
Libé, R., & Bertherat, J. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.02004 · Cited by 168 · see citing works
Molecular Markers and the Pathogenesis of Adrenocortical Cancer
Soon, P. S. H., McDonald, K. L., Robinson, B. G., & Sidhu, S. B. (2008) · The Oncologist · doi:10.1634/theoncologist.2007-0243 · Cited by 130 · see citing works
Libè, R., Groussin, L., Tissier, F., Elie, C., René-Corail, F., Fratticci, A., Jullian, E., Beck-Peccoz, P., Bertagna, X., Gicquel, C., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2085 · Cited by 115 · see citing works
Genetics and epigenetics of adrenocortical tumors
Lerário, A. M., Moraitis, A. G., & Hammer, G. D. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.10.028 · Cited by 112 · see citing works
<i>TP53</i>Germline Mutations in Adult Patients with Adrenocortical Carcinoma
Herrmann, L. J. M., Heinze, B., Fassnacht, M., Willenberg, H. S., Quinkler, M., Reisch, N., Zink, M., Allolio, B., & Hahner, S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1982 · Cited by 109 · see citing works
Schmitt, A., Saremaslani, P., Schmid, S., Rousson, V, Montani, M., Schmid, D. M., Heitz, P. U., Komminoth, P., & Perren, A. (2006) · Histopathology · doi:10.1111/j.1365-2559.2006.02505.x · Cited by 94 · see citing works
p57Kip2 and Cancer: Time for a Critical Appraisal
Borriello, A., Caldarelli, I., Bencivenga, D., Criscuolo, M., Cucciolla, V., Tramontano, A., Oliva, A., Perrotta, S., & Ragione, F. D. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0220 · Cited by 89 · see citing works
Hereditary Hormone Excess: Genes, Molecular Pathways, and Syndromes
Marx, S. J., & Simonds, W. F. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0037 · Cited by 87 · see citing works
Towards an understanding of the role of p53 in adrenocortical carcinogenesis
Wasserman, J. D., Zambetti, G. P., & Malkin, D. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.010 · Cited by 84 · see citing works
Ferruzzi, P., Ceni, E., Tarocchi, M., Grappone, C., Milani, S., Galli, A., Fiorelli, G., Serio, M., & Mannelli, M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0978 · Cited by 81 · see citing works
Montanaro, D., Maggiolini, M., Recchia, A. G., Sirianni, R., Aquila, S., Barzon, L., Fallo, F., Andò, S., & Pezzi, V. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01806 · Cited by 73 · see citing works
Development of new preclinical models to advance adrenocortical carcinoma research
Kiseljak‐Vassiliades, K., Zhang, Y., Bagby, S. M., Kar, A., Pozdeyev, N. V., Xu, M., Gowan, K., Sharma, V., Raeburn, C. D., Albuja-Cruz, M. B., et al. (2018) · Endocrine Related Cancer · doi:10.1530/erc-17-0447 · Cited by 72 · see citing works
Carney complex with adrenal cortical carcinoma
Morin, E., Mete, O., Wasserman, J. D., Joshua, A. M., Asa, S. L., & Ezzat, S. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2321 · Cited by 69 · see citing works
Schimmack, S. J., Taylor, A., Lawrence, B. J., Alaimo, D., Schmitz‐Winnenthal, H., Büchler, M. W., Modlin, I. M., & Kidd, M. S. (2014) · Epigenetics & Chromatin · doi:10.1186/1756-8935-7-15 · Cited by 63 · see citing works
Sant, H. P. V., Bouvy, N. D., Geert Kazemier, M., Bonjer, H. J., Hop, W. C. J., Feelders, R. A., de Herder, W. W., & de Krijger, R. R. (2007) · Histopathology · doi:10.1111/j.1365-2559.2007.02747.x · Cited by 56 · see citing works
Clinical and molecular aspects of adrenocortical tumourigenesis
Sidhu, S. B., Gicquel, C., Bambach, C. P., Campbell, P. R., Magarey, C. J., Robinson, B. G., & Delbridge, L. (2003) · ANZ Journal of Surgery · doi:10.1046/j.1445-2197.2003.02746.x · Cited by 56 · see citing works
Adrenocortical cancer: recent clinical and molecular advances
Sidhu, S. B., Sywak, M. S., Robinson, B. G., & Delbridge, L. (2003) · Current Opinion in Oncology · doi:10.1097/00001622-200401000-00004 · Cited by 51 · see citing works
Signaling Pathways in Adrenocortical Cancer
Kirschner, L. S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04338.x · Cited by 49 · see citing works
Mutation and methylation analysis of TP53 in adrenal carcinogenesis
Sidhu, S., Martin, E. W., Gicquel, C., Melki, J. R., Clark, S. J., Campbell, P., Magarey, C. J., Schulte, K., Röher, H.-D., Delbridge, L., et al. (2005) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2005.01.013 · Cited by 49 · see citing works
Landscape of Germline and Somatic Mitochondrial DNA Mutations in Pediatric Malignancies
Tříska, P., Kaneva, K., Merkurjev, D., Sohail, N., Falk, M. J., Triche, T. J., Biegel, J. A., & Gai, X. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2220 · Cited by 48 · see citing works
Clinical impact of TP53 alterations in adrenocortical carcinomas
Waldmann, J., Patsalis, N., Fendrich, V., Langer, P., Saeger, W., Chaloupka, B., Ramaswamy, A., Faßnacht, M., Bartsch, D. K., & Slater, E. P. (2011) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-011-0868-6 · Cited by 45 · see citing works
Therapeutic Targets for Adrenocortical Carcinoma in the Genomics Era
Mohan, D. R., Lerário, A. M., & Hammer, G. D. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00197 · Cited by 42 · see citing works
The Genetics of Adrenocortical Tumors
Espiard, S., & Bertherat, J. Y. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.02.004 · Cited by 42 · see citing works
Gene expression profiling in adrenocortical neoplasia
Assié, G., Giordano, T. J., & Bertherat, J. Y. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.044 · Cited by 41 · see citing works
The molecular basis of adrenocortical cancer
Lehmann, T. P., & Wrzesiński, T. (2012) · Cancer Genetics · doi:10.1016/j.cancergen.2012.02.009 · Cited by 34 · see citing works
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Patalano, A., Brancato, V., & Mantero, F. (2009) · Hormone Research in Paediatrics · doi:10.1159/000178049 · Cited by 34 · see citing works
Classification of adrenal cortical tumors: What limits for the pathological approach?
Tissier, F. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.10.011 · Cited by 34 · see citing works
Hertel, N. T., Carlsen, N., Kerndrup, G. B., PEDERSEN, I. L., Clausen, N., Hahnemann, J., & Jacobsen, B. (2003) · Acta Paediatrica · doi:10.1111/j.1651-2227.2003.tb00575.x · Cited by 31 · see citing works
McNicol, A. M. (2008) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2008-132-1263-lotac · Cited by 28 · see citing works
Copy number variations alter methylation and parallel IGF2 overexpression in adrenal tumors
Nielsen, H. M., How‐Kit, A., Guérin, C., Castinetti, F., Vollan, H. K. M., Micco, C. D., Daunay, A., Taïeb, D., Loo, P. V., Besse, C., et al. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0086 · Cited by 28 · see citing works
Chukkalore, D., MacDougall, K. N., Master, V. A., Bilen, M. A., & Nazha, B. (2024) · The Oncologist · doi:10.1093/oncolo/oyae029 · Cited by 29 · see citing works
Molecular pathology of adrenal cortical tumors: Separating adenomas from carcinomas
Giordano, T. J. (2006) · Endocrine Pathology · doi:10.1007/s12022-006-0007-z · Cited by 27 · see citing works
Apoptosis control and proliferation marker in human normal and neoplastic adrenocortical tissues
BERNINI, G. P., Moretti, A., Viacava, P., Bonadio, A. G., Iacconi, P., Miccoli, P., & Salvetti, A. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600287 · Cited by 25 · see citing works
A Diagnostic Approach to Adrenal Cortical Lesions
McNicol, A. M. (2008) · Endocrine Pathology · doi:10.1007/s12022-008-9055-x · Cited by 24 · see citing works
Childhood Adrenocortical Tumours: a Review
Pereira, R. M., DeLacerda, L., Lacerda, H. M., Michalkiewicz, E., Sandrini, F., & Sandrini, R. (2006) · Hereditary Cancer in Clinical Practice · doi:10.1186/1897-4287-4-2-81 · Cited by 22 · see citing works
Surgical Management of Adrenocortical Carcinoma
Ranvier, G. G. F., & Inabnet, W. B. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.02.008 · Cited by 22 · see citing works
The Role of Immunohistochemical Markers for the Diagnosis and Prognosis of Adrenocortical Neoplasms
Angelousi, A. G., Kyriakopoulos, G., Athanasouli, F., Dimitriadi, A., Kassi, E. N., Aggeli, C., Zografos, G., & Kaltsas, G. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030208 · Cited by 21 · see citing works
The Immunotherapy Landscape in Adrenocortical Cancer
Pegna, G. J., Roper, N., Kaplan, R. N., Bergsland, E. K., Kiseljak‐Vassiliades, K., Habra, M. A., Pommier, Y. G., & Rivero, J. D. (2021) · Cancers · doi:10.3390/cancers13112660 · Cited by 21 · see citing works
Apoptosis regulation in adrenocortical carcinoma
Pereira, S. S., Monteiro, M. P., Antonini, S. R. R., & Pignatelli, D. (2019) · Endocrine Connections · doi:10.1530/ec-19-0114 · Cited by 19 · see citing works
MECHANISMS OF ENDOCRINOLOGY: Cell cycle regulation in adrenocortical carcinoma
Pereira, S. S., Monteiro, M. P., Bourdeau, I., Lacroix, A., & Pignatelli, D. (2018) · European Journal of Endocrinology · doi:10.1530/eje-17-0976 · Cited by 16 · see citing works
p53 as a prognostic factor in adrenocortical tumors of adults and children
Sredni, S. T., Zerbini, M. C. N., Latorre, M. R. D. O., & Alves, V. A. F. (2003) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2003000100004 · Cited by 15 · see citing works
Is there a role for epithelial-mesenchymal transition in adrenocortical tumors?
Bulzico, D., de Faria, P. A. S., Maia, C. B., de Paula, M. P., Torres, D. C., Ferreira, G. M., Pires, B. R. B., Hassan, R., Abdelhay, E. S. F. W., Vaisman, M., et al. (2017) · Endocrine · doi:10.1007/s12020-017-1409-z · Cited by 14 · see citing works
Gniado, E., Carracher, C. P., & Sharma, S. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz269 · Cited by 13 · see citing works
Bulzico, D., Torres, D. C., Ferreira, G. M., Pires, B. R. B., de Faria, P. A. S., Hassan, R., Abdelhay, E. S. F. W., Vaisman, M., & Neto, L. V. (2017) · Endocrine Pathology · doi:10.1007/s12022-017-9482-7 · Cited by 11 · see citing works
Szyszka, P., Grossman, A. B., Díaz‐Cano, S. J., & Dorota Dworakowska, B. (2015) · Endokrynologia Polska · doi:10.5603/ep.a2016.0054 · Cited by 11 · see citing works
Martins, A. C. P., Cologna, A. J., Tucci, S., Suaid, H. J., & Falconi, R. A. R. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000157683.55748.41 · Cited by 10 · see citing works
Brown, T. C., Nicolson, N. G., Stenman, A., Juhlin, C. C., Gibson, C. E., Callender, G. G., Korah, R. M., & Carling, T. (2019) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2019.04.018 · Cited by 9 · see citing works
Giovannoni, I., Boldrini, R., Benedetti, M. C., Inserra, A., Pasquale, M. D. D., & Francalanci, P. (2016) · Pediatric Research · doi:10.1038/pr.2016.239 · Cited by 7 · see citing works
Sengupta, M., Chatterjee, G., Bera, M. K., Chowdhury, S., Mukherjee, G., Datta, C., & Chatterjee, U. (2015) · Indian Journal of Pathology and Microbiology · doi:10.4103/0377-4929.155308 · Cited by 7 · see citing works
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Jeyaraman, K., Concolino, P., & Falhammar, H. (2024) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2024.2431748 · Cited by 6 · see citing works
Assessment of Malignancy in Adrenal Cortical Tumors
McNicol, A. M. (2006) · Endocrine Pathology · doi:10.1385/ep:17:2:131 · Cited by 6 · see citing works
Tumores adrenocorticais na criança: da abordagem clínica à avaliação molecular
Antonini, S. R. R., Colli, L. M., Ferro, L., Mermejo, L. M., & de Castro, M. (2011) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302011000800014 · Cited by 6 · see citing works
Overview of Genetic Syndromes Associated with Adrenocortical Cancer
Else, T. (2009) · Springer eBooks · doi:10.1007/978-0-387-77236-3_10 · Cited by 5 · see citing works
Tumeurs sécrétantes de la corticosurrénale
Mongiat-Artus, P., Miquel, C., MERIA, P., Hernigou, A., & Duclos, J.-M. (2004) · Annales d Urologie · doi:10.1016/j.anuro.2004.05.001 · Cited by 5 · see citing works
Zheng, G., Zhang, X., Li, H., Zhang, Y., Deng, J., & Wu, X. (2021) · Biochemical Genetics · doi:10.1007/s10528-021-10039-w · Cited by 6 · see citing works
Adrenal Cortex Tumors and Hyperplasias
Pignatelli, D. (2011) · InTech eBooks · doi:10.5772/19108 · Cited by 4 · see citing works
Alam, W., Bouferraa, Y., Haibe, Y., & Shamseddine, A. I. (2021) · Clinical Medicine Insights Oncology · doi:10.1177/11795549211007682 · Cited by 4 · see citing works
Lerário, A. M., Mendonca, B. B., & Lin, C. J. (2005) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302005000500016 · Cited by 4 · see citing works
Tumors of the Endocrine System
Norton, J. A. (2007) · Springer eBooks · doi:10.1007/0-387-31056-8_56 · Cited by 3 · see citing works
Discerning malignancy in resected adrenocotical tumors
Hironobu, S., Suzuki, T., & Nakamura, Y. (2008) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2.10.1095 · Cited by 2 · see citing works
Weiss, L. M., & Lau, S. K. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3966-2.00045-x · Cited by 2 · see citing works
Pereira, R. M. (2006) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 2 · see citing works
Tissier, F. (2008) · Annales de Pathologie · doi:10.1016/j.annpat.2008.07.005 · Cited by 2 · see citing works
Cellular and Molecular Pathology of Adrenocortical Carcinoma
Else, T. (2009) · Springer eBooks · doi:10.1007/978-0-387-77236-3_9 · Cited by 1 · see citing works
Germline and somatic genetic drivers of adrenocortical tumours
Bouys, L., & Bertherat, J. Y. (2026) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2026.102099 · Cited by 1 · see citing works
Sasano, H., Nakamura, Y., Moriya, T., & Suzuki, T. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1069-1_11 · Cited by 1 · see citing works
Present and Future of Personalised Medicine for Endocrine Cancers
Ronchi, C. L., & Altieri, B. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-4329-1 · Cited by 1 · see citing works
Li–Fraumeni syndrome: a role for surgical pathologists?
Dickson, B. C. (2012) · Diagnostic histopathology · doi:10.1016/j.mpdhp.2012.01.003 · Cited by 1 · see citing works
Estudo da Beta-catenina em tumores adrenocorticais humanos
Lima, L. D. O. (2014) · doi:10.11606/t.5.2014.tde-14082014-151107 · Cited by 1 · see citing works
Tissier, F. (2009) · Annales d Endocrinologie · doi:10.1016/j.ando.2009.02.014 · Cited by 1 · see citing works
Identification of Novel Hub Genes Through Expression Profiles Analysis in Adrenocortical CarcinomaPreprint
Yao, C., Zhao, X., Shang, X., Jia, B., Dou, S., Ye, W., & Yang, Y. (2020) · doi:10.21203/rs.3.rs-38768/v1 · Cited by 1 · see citing works
GATA TRANSCRIPTION FACTORS IN THE DEVELOPMENT AND TUMORS OF THE ADRENAL CORTEX
Kiiveri, S. (2004) · Työväentutkimus Vuosikirja
Tumeurs s�cr�tantes de la corticosurr�nale
Mongiat-Artus, P. (2004) · Annales d Urologie · doi:10.1016/s0003-4401(04)00045-2
Tumores secretantes de la corteza suprarrenal
Mongiat-Artus, P., Miquel, C., MERIA, P., Hernigou, A., & Duclos, J.-M. (2004) · EMC - Urología · doi:10.1016/s1761-3310(04)41522-9
Importância da via do mevalonato nas neoplasias do córtex adrenal
Valassi, H. P. L. (2011) · doi:10.11606/t.5.2011.tde-18022011-122810
Lerário, A. M., Giordano, T. J., & Hammer, G. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416006-4.00025-9
Zambetti, G. P., & Ribeiro, R. C. (2009) · Springer eBooks · doi:10.1007/978-0-387-77236-3_12
Tumeurs sécrétantes de la corticosurrénale
Mongiat-Artus, P., Miquel, C., MERIA, P., Hernigou, A., & Duclos, J.-M. (2008) · Annales d Urologie · doi:10.1016/s1762-0953(06)75014-2
Higham, C. E., Coen, J. J., Boland, G. W., & Trainer, P. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-560-2_4
Genetics of Familial Forms of Cortisol-Secreting Adrenal Tumors and Hyperplasias
Drougat, L., & Stratakis, C. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64349-0
New diagnostic and therapeutic approaches in adrenocortical cancer.
Khan, T. S. (2004) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Molecular biology, genetic, and epigenetics of adrenal tumor
Baghdadabad, L. Z., Ahadi, Z., Roudgari, H., & Ebrahimi, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-27302-5.00017-6
Genetics of Familial Forms of Cortisol-Secreting Adrenal Tumors and Hyperplasias
Drougat, L., & Stratakis, C. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00417-9
Génomique intégrée des tumeurs bénignes corticosurrénaliennes
Faillot, S. (2017) · theses.fr (ABES) · doi:10.70675/36869127z1fb2z41bbzb082z1048e489a8e6
- Authors
- Barzon, L., Chilosi, M., Fallo, F., Martignoni, G., Montagna, L., Palu, G., & Boscaro, M.
- Affiliations
- University of Padua (IT)
- University of Verona (IT)
- Corresponding author
- Barzon, L
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-08-01
- Volume
- 145
- Issue
- 2
- Pages
- 207-212
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2026435298
- Cited by
- 94
- References
- 20
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Regione del Veneto
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- CDKN1C, TP53, p57KIP2, p21, adrenocortical carcinoma, adrenal adenoma, adrenal tumors, TP53 mutation, tumor suppressor, cyclin-dependent kinase inhibitors
- MeSH terms
- Adrenal Gland Neoplasms, Adult, DNA, Neoplasm, Female, Humans, Immunohistochemistry, Male, Middle Aged, Nuclear Proteins, RNA, Neoplasm, Gene Expression Regulation, Neoplastic, Genes, p53, Tumor Suppressor Protein p53, Frameshift Mutation, Gene Deletion, Adrenocortical Adenoma, Adrenocortical Carcinoma, Polymorphism, Single-Stranded Conformational, Reverse Transcriptase Polymerase Chain Reaction, Cyclin-Dependent Kinase Inhibitor p57
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