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Cited by 139Adrenal and Paraganglionic TumorsCancer-related Molecular PathwaysChromatin Remodeling and Cancer

p53 Mutations in sporadic adrenocortical tumors

Ohgaki, H., Kleihues, P., Heitz, P. U.·1993·International Journal of Cancer
DOI 10.1002/ijc.2910540310
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Abstract

Non-familial human adrenocortical adenomas and carcinomas were screened for mutations in exons 5-8 of the p53 tumor suppressor gene by single-strand-conformation-polymorphism (SSCP) analysis, followed by direct sequencing of PCR-amplified DNA. Point mutations in codons 12, 13 and 61 in H-ras, K-ras and N-ras proto-oncogenes were similarly assessed by direct DNA sequencing. Three out of 15 primary adrenocortical carcinomas (20%) contained a mis-sense point mutation in the conserved regions (exons 5 and 8) of the p53 gene. Mutations were located in codon 157 (GTC-->TTC; Val-->Phe), codon 163 (TAC-->AAC; Tyr-->Asn), and codon 273 (CGT-->TGT; Arg-->Cys). The mutation in codon 157 was detected in the primary tumor as well as in brain and lymph-node metastases. Among 18 adrenocortical adenomas, there was only a single non-miscoding mutation in codon 295 (CCT-->CCC; Pro-->Pro). These data suggest that mutational inactivation of the p53 gene occurs in a minority (20%) of sporadic adrenocortical carcinomas and that these mutations constitute a late event in the multi-step process of malignant transformation. No ras mutations were detected in any of these tumors, suggesting that these genes are not involved in the development of tumors originating from the adrenal cortex.

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Crossref · 10.1002/ijc.2910540310

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  • High-grade ACCs are enriched for mutations of TP53 and/or CTNNB1, and these mutations tend to be mutually exclusive.

    “High-grade ACCs are enriched for mutations of TP53 (14, 140–142) and/or CTNNB1 (143–149), and these mutations tend to be mutually exclusive (reviewed in Ref. 150).”

    From Adrenocortical carcinoma (2014) · cites this paper as [140]

  • TP53 is the most commonly mutated gene in ACC, present in at least one-third of ACCs.

    “TP53 located on 17p13 is the most commonly mutated gene in ACC, present in at least one-third of ACCs (140, 142, 202).”

    From Adrenocortical carcinoma (2014) · cites this paper as [140]

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Authors
Ohgaki, H., Kleihues, P., & Heitz, P. U.
Affiliations
University Hospital Zurich (CH)
Corresponding author
Kleihues, P.
ORCID
Ohgaki, H.
Venue
International Journal of Cancer
Publisher
Wiley
Published
1993-05-28
Volume
54
Issue
3
Pages
408-410
ISSN
  • 0020-7136 (ISSN-L)
  • 1097-0215
DOI
10.1002/ijc.2910540310
OpenAlex
W2033246829
Cited by
139
References
29
Citations by year
2026: 1 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 4 · 2012: 8
FWCI
5.86
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4798 d)
Locations
  • International Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
TP53 mutation, adrenocortical carcinoma, adrenal adenoma, adrenal cortex neoplasms, H-Ras, KRAS, NRAS, Ras proto-oncogene, metastatic cancer, malignant transformation, tumor suppressor inactivation
MeSH terms
Adenoma, Adolescent, Adrenal Cortex Neoplasms, Adult, Aged, Aged, 80 and over, Base Sequence, Carcinoma, Chromosomes, Human, Pair 17, Codon, DNA, Single-Stranded, Exons, Female, Humans, Male, Middle Aged, Molecular Sequence Data, Polymorphism, Genetic, Genes, ras, Genes, p53, Point Mutation

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