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Cited by 162Adrenal and Paraganglionic TumorsPituitary Gland Disorders and TreatmentsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Development of overt Cushing’s syndrome in patients with adrenal incidentaloma

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Barzon, L, Fallo, F, Sonino, N, Boscaro, M·2002·European Journal of Endocrinology
DOI 10.1530/eje.0.1460061
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Abstract

OBJECTIVE: The natural course of adrenal incidentalomas, especially those with subclinical autonomous glucocorticoid production, i.e. subclinical Cushing's syndrome, and the risk that such conditions will evolve towards overt Cushing's syndrome are unknown. DESIGN: Longitudinal follow-up evaluation of a series of 284 consecutive patients with adrenal incidentaloma. METHODS AND RESULTS: Out of 284 consecutive patients with adrenal incidentaloma studied at our Institution in the last 15 years, 98 patients (23 with subclinical hypercortisolism) underwent surgery. Of 130 non-operated patients with a follow-up of at least 1 year, eight had subclinical hypercortisolism at diagnosis. We describe in detail four patients who developed overt Cushing's syndrome after 1-3 years of follow-up. Only one of these patients had subclinical hypercortisolism at first diagnosis. Estimated cumulative risk for a non-secreting adrenal incidentaloma to develop subclinical hyperfunction was 3.8% after 1 year and 6.6% after 5 years. For patients with masses with subclinical autonomous glucocorticoid overproduction, estimated cumulative risk to develop overt Cushing's syndrome was 12.5% after 1 year. CONCLUSIONS: In patients with adrenal incidentalomas the risk of progression towards overt Cushing's syndrome is not low, at variance with previous reports. A careful biochemical and hormonal follow-up is advisable in all patients who do not need surgery at first presentation.

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Crossref · 10.1530/eje.0.1460061

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Metadata

Authors
Barzon, L., Fallo, F., Sonino, N., & Boscaro, M.
Affiliations
University of Padua (IT)
Corresponding author
Boscaro, M
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2002-01-01
Volume
146
Issue
1
Pages
61-66
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje.0.1460061
OpenAlex
W2140530355
Cited by
162
References
16
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 10 · 2014: 16 · 2013: 8 · 2012: 13
FWCI
6.05
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
adrenal incidentaloma, subclinical Cushing's syndrome, subclinical hypercortisolism, progression risk, cumulative risk, follow-up
MeSH terms
Adolescent, Adrenal Gland Neoplasms, Adult, Aged, Cushing Syndrome, Female, Follow-Up Studies, Hormones, Humans, Male, Middle Aged, Disease Progression

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