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The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Epidemiology of subtypes of hypothyroidism in Denmark.

Carlé, Allan, Laurberg, Peter, Pedersen, Inge Bülow, Knudsen, Nils, Perrild, Hans, Ovesen, Lars, Rasmussen, Lone Banke, Jorgensen, Torben·2006·European Journal of Endocrinology
DOI 10.1530/eje.1.02068
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Abstract

OBJECTIVE: Studies of hypothyroidism are often based on referred patients, and limited information is available on the incidence rates of subtypes of hypothyroidism in the general population. We therefore studied incidences of subtypes of primary, overt hypothyroidism in a Danish population cohort and compared incidences in two subcohorts with different levels of iodine intake. DESIGN: A prospective population-based study, monitoring a well-defined cohort representative of the Danish population. METHODS: The Danish Investigation of Iodine Intake and Thyroid Diseases registry of hyper- and hypothyroidism was established as part of the monitoring of the iodine fortification of salt in Denmark. A computer-based system linked to laboratory databases identified all patients diagnosed with new, biochemically overt hypothyroidism in populations living in Aalborg (moderate iodine deficiency, n = 311,102) and Copenhagen (mild iodine deficiency, n = 227,632). We subsequently evaluated all identified patients to verify incident thyroid disease, and subclassified hypothyroidism into nosological types. RESULTS: During a 4-year period (2,027,208 person-years) 685 new cases of overt hypothyroidism were diagnosed in the cohort; the incidence rate was 32.8 per 100,000 person-years (standardised to the Danish population). Nosological types of hypothyroidism were: spontaneous (presumably autoimmune) 84.4%, post-partum 4.7%, amiodarone-associated 4.0%, subacute thyroiditis 1.8%, previous radiation or surgery 1.8%, congenital 1.6% and lithium-associated 1.6%. Crude incidence rates were 29.0 around Aalborg and 40.6 in an area of Copenhagen. The higher incidence rate of hypothyroidism in the area with higher iodine intake was caused solely by more cases of spontaneous (presumably autoimmune) hypothyroidism, whereas the incidence of non-spontaneous hypothyroidism (all types combined) was significantly lower in the area with higher iodine intake. CONCLUSION: In a population-based study we observed a higher incidence of hypothyroidism with higher iodine intake. This was due solely to the entity of spontaneous hypothyroidism. The occurrence of overt hypothyroidism was relatively low in Denmark.

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Research works printed but not linked: 4

  1. Galofr, 1994, Medline Rows With NULL issns Will Point To This, 6, 49
  2. 2003, IDD NEWSLETTER, 19, 55
  3. Pedersen, 1997, Ugeskrift for laeger, 159, 2201
  4. Simonsen, 1998, Ugeskrift for laeger, 160, 5777

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Metadata

Authors
Carlé, A., Laurberg, P., Pedersen, I. B., Knudsen, N., Perrild, H., Ovesen, L., Rasmussen, L. B., & Jorgensen, T.
Affiliations
  • Aalborg University Hospital (DK)
  • Bispebjerg Hospital (DK)
  • Hjerteforeningen (DK)
ORCID
Venue
European Journal of Endocrinology
Publisher
Oxford University Press (OUP)
Published
2006-01
Volume
154
Issue
1
Pages
21-28
ISSN
  • 0804-4643 (ISSN-L)
  • 1479-683X
DOI
10.1530/eje.1.02068
OpenAlex
W2121837488
Cited by
195
References
34
Citations by year
2026: 8 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 10 · 2020: 3 · 2019: 13 · 2018: 11 · 2017: 12 · 2016: 13 · 2015: 14 · 2014: 11 · 2013: 12 · 2012: 14
FWCI
3.31
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Funders
Bispebjerg Hospital
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
hypothyroidism, overt hypothyroidism, incidence, iodine intake, iodine deficiency, autoimmune hypothyroidism, nosological classification, postpartum hypothyroidism, amiodarone-induced hypothyroidism, subacute thyroiditis, population-based cohort
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Autoantibodies, Child, Child, Preschool, Denmark, Female, Humans, Hypothyroidism, Infant, Infant, Newborn, Iodide Peroxidase, Iodine, Male, Middle Aged, Prospective Studies, Puerperal Disorders, Registries, Sex Factors, Cohort Studies, Incidence

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