CoChat
Sign Up
Cited by 50Thyroid Cancer Diagnosis and TreatmentEffects of Radiation ExposureRadiation Dose and Imaging

Cancer risk after medical exposure to radioactive iodine in benign thyroid diseases: a meta-analysis

Hieu, Trinh Trung, Russell, Anthony W, Cuneo, Ross, Clark, Justin, Kron, Tomas, Hall, Per, Doi, Suhail A R·2012·Endocrine-Related Cancer
DOI 10.1530/erc-12-0176
Open this paper in CoChat — free account

Abstract

Radioiodine-131 ( 131 I) is widely used for diagnosis and treatment of benign thyroid diseases. Observational studies have not been conclusive about the carcinogenic potential of 131 I and we therefore conducted a meta-analysis. We performed a literature search till September 2011 which included 131 I as a diagnostic or treatment modality ( 131 I for treatment of thyroid cancer was excluded). Data on 64 different organ or organ group subsets comprising 22 029 exposed subjects in the therapeutic cohorts and 24 799 in the diagnostic cohorts in seven studies were included. Outcome was pooled as the relative risk (RR) using both standard and bias adjusted methods. Quality assessment was performed using a study-specific instrument. No increase in overall (RR 1.06, 95% CI: 0.94–1.19), main organ group or combined organ group (four groups known to concentrate 131 I; RR 1.11, 95% CI: 0.94–1.31) risks was demonstrable. Individual organs demonstrated a higher risk for kidney (RR 1.70, 95% CI: 1.15–2.51) and thyroid (RR 1.99, 95% CI: 1.22–3.26) cancers with a strong trend for stomach cancer (RR 1.11, 95% CI: 0.92–1.33). A thyroid dose effect was seen for diagnostic doses. While there is no increase in the overall burden of cancer, an increase in risk to a few organs is seen which requires substantiation. The possible increase in thyroid cancer risk following diagnostic 131 I use should no longer be of concern given that it has effectively been replaced by the use of 99mTc-pertechnetate.

Integrity signals

Registry

Crossref · 10.1530/erc-12-0176

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 62 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Hieu, T. T., Russell, A. W., Cuneo, R., Clark, J., Kron, T., Hall, P., & Doi, S. A. R.
Affiliations
The University of Queensland (AU)
Corresponding author
Doi, Suhail A R
ORCID
Venue
Endocrine-Related Cancer
Publisher
Bioscientifica
Published
2012-07-31
Volume
19
Issue
5
Pages
645-655
ISSN
  • 1351-0088 (ISSN-L)
  • 1479-6821
DOI
10.1530/erc-12-0176
OpenAlex
W2100437654
Cited by
50
References
62
Citations by year
2026: 1 · 2025: 2 · 2022: 4 · 2021: 7 · 2020: 10 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 1
FWCI
0.53
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Related Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • ANU Open Research (Australian National University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiation Dose and Imaging
Keywords
benign thyroid disease, cancer risk, radiation-induced cancer, thyroid cancer, kidney cancer, gastric cancer, technetium-99m pertechnetate
MeSH terms
Humans, Iodine Radioisotopes, Neoplasms, Risk, Thyroid Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review