The DOI matches its Crossref record; 226 of the 227 references it cites were found in a registry or an index.
60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH
Abstract
The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and stress response and is thus the major component of the hypothalamo–pituitary–adrenal axis. After a brief summary of ACTH production from proopiomelanocortin (POMC) and on ACTH receptor properties, the first part of the review covers the role of ACTH in steroidogenesis and steroid secretion. We highlight the mechanisms explaining the differential acute vs chronic effects of ACTH on aldosterone and glucocorticoid secretion. The second part summarizes the effects of ACTH on adrenal growth, addressing its role as either a mitogenic or a differentiating factor. We then review the mechanisms involved in steroid secretion, from the classical Cyclic adenosine monophosphate second messenger system to various signaling cascades. We also consider how the interaction between the extracellular matrix and the cytoskeleton may trigger activation of signaling platforms potentially stimulating or repressing the steroidogenic potency of ACTH. Finally, we consider the extra-adrenal actions of ACTH, in particular its role in differentiation in a variety of cell types, in addition to its known lipolytic effects on adipocytes. In each section, we endeavor to correlate basic mechanisms of ACTH function with the pathological consequences of ACTH signaling deficiency and of overproduction of ACTH.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Previously, the direct receptor-mediated anti-inflammatory effects of ACTH and succinate on immune cells associated with blockages of pro-inflammatory polarization have been shown [51,52,89].”
From Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis (2021) · cites this paper as [51]
In the citing paper
“The drugs’ abilities to exert neurotrophic effects may be mediated by the activation of specific receptors: SUCNR1 for Mexidol and receptors of the melanocortin family MCRs for Semax [51,52,59,60].”
From Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis (2021) · cites this paper as [51]
In the citing paper
“The treatment with Mexidol and Semax, especially Mexidol, prolonged the period of PGC-1α activation, which may be related to the receptor-mediated (by SUCNR1 and MCRs) initiation of calcium signaling cascades in neurons [51,52,59,60].”
From Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis (2021) · cites this paper as [51]
Citations
Cites
Items 201–226 of 226
ACTH Induces Cav3.2 Current and mRNA by cAMP-dependent and cAMP-independent Mechanisms
Liu, H., Enyeart, J. A., & Enyeart, J. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.104190 · Cited by 19
Lessons from the gene expression pattern of the rat zona glomerulosa
Nishimoto, K., Rainey, W. E., Bollag, W. B., & Seki, T. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.12.023 · Cited by 18
Hafiz, S., Dennis, J. C., Schwartz, D. D., Judd, R. L., Tao, Y., Khazal, K. F., Akingbemi, B. T., Mo, X., Abdel‐Mageed, A. B., Morrison, E. E., et al. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1574 · Cited by 18
Cooke, M., Mele, P. G., Maloberti, P. M., Duarte, A., Poderoso, C., Orlando, U. D., Paz, C., Maciel, F. C., & Podesta, E. J. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.030 · Cited by 17
Roy, S. F., Pinard, S., Chouinard, L. A., & Gallo‐Payet, N. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.12.030 · Cited by 17
Self-citationEffects of ACTH-(11-24) on the corticosteroid production of isolated adrenocortical cells
Szalay, K. S., de Wied, D., & Stark, E. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90261-6 · Cited by 17
Carsia, R. V., Tilly, K. I., & Tilly, J. L. (1997) · Endocrine · doi:10.1007/bf02801333 · Cited by 16
High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex
Jefcoate, C. R. E. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200216771 · Cited by 15
A genome-wide assessment of adrenocorticotropin action in the Y1 mouse adrenal tumor cell line
Schimmer, B. P., Cordova, M., Cheng, H. S., Tsao, A., & Morris, Q. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.024 · Cited by 14
Rebuffat, P., Cavallini, L., Belloni, A. S., Mazzocchi, G., Coi, A., Tos, G. P. D., & Nussdorfer, G. G. (1989) · PubMed · Cited by 14
Hofland, J., Steenbergen, J., Hofland, L. J., van Koetsveld, P. M., Eijken, M., van Nederveen, F. H., Geert Kazemier, M., de Herder, W. W., Feelders, R. A., & de Jong, F. H. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00034.2013 · Cited by 13
60 YEARS OF POMC: N-terminal POMC peptides and adrenal growth
Bicknell, A. B. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0269 · Cited by 13
Evans, J. F., Fernando, A. N., & Ragolia, L. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.01.019 · Cited by 12
Eph receptors and zonation in the rat adrenal cortex
Brennan, C. H., Chittka, A., Barker, S., & Vinson, G. P. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0084 · Cited by 12
Calcium action potentials in cultured adrenocortical cells
Tabares, L., & Barneo, J. L. (1986) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00580669 · Cited by 11
Riondel, A. M., Rebuffat, P., Mazzochi, G., Nussdorfer, G. G., Gaillard, R. C., Bockhorn, L., Nussberger, J., Vallotton, M. B., & Muller, A. F. (1987) · European Journal of Endocrinology · doi:10.1530/acta.0.1140047 · Cited by 11
Phosphodiesterase 8B and cyclic AMP signaling in the adrenal cortex
Leal, L. F., Szarek, E., Faucz, F. R., & Stratakis, C. A. (2015) · Endocrine · doi:10.1007/s12020-015-0621-y · Cited by 9
Calcium channels do not play a role in the steroid response to acth in Yl adrenocortical cells
Coyne, M. D., Wang, G., & Lémos, J. R. (1996) · Endocrine Research · doi:10.1080/07435809609043745 · Cited by 9
Evans, J. F., Rodriguez, S., & Ragolia, L. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1561-6 · Cited by 9
Lymangrover, J. R. (1980) · Cellular and Molecular Life Sciences · doi:10.1007/bf01965834 · Cited by 9
Mc2 Receptor Knockdown Modulates Differentiation and Lipid Composition in Adipocytes
Betz, M. J., Hatiboglu, N., Mauracher, B., Hadaschik, D., Sauter, A. P., Demmelmair, H., Koletzko, B. V., Beuschlein, F., & Slawik, M. (2012) · Hormone and Metabolic Research · doi:10.1055/s-0032-1314854 · Cited by 9
Melanocortins and body weight regulation: Glucocorticoids, Agouti-related protein and beyond
Corander, M. P., & Coll, A. P. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.10.103 · Cited by 7
Cao, C., Yang, X., Gao, Y., ZHUANG, M., WANG, K. P., Sun, L., & WANG, X. S. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1144 · Cited by 6
Bird, I., Smith, A. D., & Schulster, D. (1990) · PubMed · Cited by 5
Chapter 4. The Fetal Adrenal Cortex
(1986) · International review of cytology · doi:10.1016/s0074-7696(08)61912-9 · Cited by 4
Research works printed but not linked: 15
- 10.1210/jc.81.6.2171 · DOI
- 10.1210/en.136.3.956 · DOI
- 10.1210/jc.87.4.1819 · DOI
- 10.1210/en.130.5.2883 · DOI
- 10.1210/me.16.6.1417 · DOI
- 10.1210/jc.86.9.4495 · DOI
- 10.1210/me.7.8.1031 · DOI
- 10.1002/(SICI)1097-0029(19970315)36:6<463::AID-JEMT4>3.0.CO;2-J · DOI
- 10.1210/en.137.8.3291 · DOI
- 10.1210/en.142.10.4282 · DOI
- 10.1210/en.134.6.2589 · DOI
- 10.1210/jc.86.11.5130 · DOI
- 10.1210/en.138.11.4591 · DOI
- 10.1210/jc.81.7.2746 · DOI · Paper page
- Vinson G Hinson J 1992 Blood flow and hormone secretion in the adrenal gland. In The Adrenal Gland, pp 71–104. Ed James VHT . New York, NY, USA: Raven Press.
Cited by
Sorted by citations
POMC: The Physiological Power of Hormone Processing
Harno, E., Ramamoorthy, T. G., Coll, A. P., & White, A. E. (2018) · Physiological Reviews · doi:10.1152/physrev.00024.2017 · Cited by 286
Role of ACTH and Other Hormones in the Regulation of Aldosterone Production in Primary Aldosteronism
Ghorayeb, N. E., Bourdeau, I., & Lacroix, A. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00072 · Cited by 109
The Biology of Normal Zona Glomerulosa And Aldosterone-Producing Adenoma: Pathological Implications
Seccia, T. M., Caroccia, B., Gómez-Sánchez, E. P., Gómez-Sánchez, C. E., & Rossi, G. P. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00060 · Cited by 98
Kinlein, S. A., & Karatsoreos, I. N. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100819 · Cited by 102
ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms?
Frīdmanis, D., Roga, A., & Kloviņš, J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00013 · Cited by 82
Metadata
- Authors
- Gallo-Payet, N.
- Affiliations
- 1Division of EndocrinologyDepartment of Medicine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2016-05
- Volume
- 56
- Issue
- 4
- Pages
- T135-T156
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2412941099
- Cited by
- 98
- References
- 227
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 11 · 2022: 5 · 2021: 16 · 2020: 9 · 2019: 9 · 2018: 7 · 2017: 14 · 2016: 8
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Université de Sherbrooke
- King's College London
- Canada Research Chairs
- Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Canadian Institutes of Health Research (MOP-10998)
- Faculty of Medicine and Health, University of Sydney
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- ACTH, proopiomelanocortin, ACTH receptor, hypothalamic-pituitary-adrenal axis, steroidogenesis, aldosterone secretion, glucocorticoid secretion, adrenal growth, cAMP signaling, extracellular matrix, cytoskeleton, cell differentiation, lipolysis, ACTH deficiency, ACTH excess, Cushing's disease
- MeSH terms
- Adrenal Cortex, Adrenal Cortex Hormones, Adrenal Glands, Adrenocorticotropic Hormone, Aldosterone, Animals, Cytoskeleton, Disease Susceptibility, Extracellular Matrix, Gene Expression Regulation, Humans, Periodicity, Protein Binding, Steroids, Signal Transduction, Reactive Oxygen Species, Adipocytes, MAP Kinase Signaling System, Genomics, Receptor, Melanocortin, Type 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
