Cited by 98Adrenal Hormones and DisordersStress Responses and CortisolHormonal Regulation and Hypertension

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60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

Gallo-Payet, Nicole·2016·Journal of Molecular Endocrinology

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Abstract

The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and stress response and is thus the major component of the hypothalamo–pituitary–adrenal axis. After a brief summary of ACTH production from proopiomelanocortin (POMC) and on ACTH receptor properties, the first part of the review covers the role of ACTH in steroidogenesis and steroid secretion. We highlight the mechanisms explaining the differential acute vs chronic effects of ACTH on aldosterone and glucocorticoid secretion. The second part summarizes the effects of ACTH on adrenal growth, addressing its role as either a mitogenic or a differentiating factor. We then review the mechanisms involved in steroid secretion, from the classical Cyclic adenosine monophosphate second messenger system to various signaling cascades. We also consider how the interaction between the extracellular matrix and the cytoskeleton may trigger activation of signaling platforms potentially stimulating or repressing the steroidogenic potency of ACTH. Finally, we consider the extra-adrenal actions of ACTH, in particular its role in differentiation in a variety of cell types, in addition to its known lipolytic effects on adipocytes. In each section, we endeavor to correlate basic mechanisms of ACTH function with the pathological consequences of ACTH signaling deficiency and of overproduction of ACTH.

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Authors: Gallo-Payet, N.
Affiliations: 1Division of EndocrinologyDepartment of Medicine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada
Venue: Journal of Molecular Endocrinology
Publisher: Bioscientifica
Published: 2016-05
Volume: 56
Issue: 4
Pages: T135-T156
ISSN: 0952-5041 (ISSN-L)
1479-6813
DOI: 10.1530/jme-15-0257
OpenAlex: W2412941099
Cited by: 98
References: 227
Citations by year: 2026: 4 · 2025: 6 · 2024: 9 · 2023: 11 · 2022: 5 · 2021: 16 · 2020: 9 · 2019: 9 · 2018: 7 · 2017: 14 · 2016: 8
FWCI: 1.85
Type: journal article
Language: en
Open access: closed
Locations: Journal of Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Université de Sherbrooke
King's College London
Canada Research Chairs
Institute of Psychiatry, Psychology and Neuroscience, King’s College London
Canadian Institutes of Health Research (MOP-10998)
Faculty of Medicine and Health, University of Sydney
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: ACTH, proopiomelanocortin, ACTH receptor, hypothalamic-pituitary-adrenal axis, steroidogenesis, aldosterone secretion, glucocorticoid secretion, adrenal growth, cAMP signaling, extracellular matrix, cytoskeleton, cell differentiation, lipolysis, ACTH deficiency, ACTH excess, Cushing's disease
MeSH terms: Adrenal Cortex, Adrenal Cortex Hormones, Adrenal Glands, Adrenocorticotropic Hormone, Aldosterone, Animals, Cytoskeleton, Disease Susceptibility, Extracellular Matrix, Gene Expression Regulation, Humans, Periodicity, Protein Binding, Steroids, Signal Transduction, Reactive Oxygen Species, Adipocytes, MAP Kinase Signaling System, Genomics, Receptor, Melanocortin, Type 2

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60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

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