The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Novel mechanisms for DHEA action
Open accessAbstract
Dehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA), secreted by the adrenal cortex, gastrointestinal tract, gonads, and brain, and its sulfated metabolite DHEA-S are the most abundant endogeneous circulating steroid hormones. DHEA actions are classically associated with age-related changes in cardiovascular tissues, female fertility, metabolism, and neuronal/CNS functions. Early work on DHEA action focused on the metabolism to more potent sex hormones, testosterone and estradiol, and the subsequent effect on the activation of the androgen and estrogen steroid receptors. However, it is now clear that DHEA and DHEA-S act directly as ligands for many hepatic nuclear receptors and G-protein-coupled receptors. In addition, it can function to mediate acute cell signaling pathways. This review summarizes the molecular mechanisms by which DHEA acts in cells and animal models with a focus on the ‘novel’ and physiological modes of DHEA action.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081
Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4160 · Cited by 713
Monnet, F. P., Mahé, V, Robel, P., & Baulieu, E. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3774 · Cited by 429
Labrie, F., Luu-The, V., Labrie, C., & Simard, J. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0216 · Cited by 366
Compagnone, N. A., & Mellon, S. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4678 · Cited by 327
Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.
Coleman, D. L., Leiter, E. H., & Schwizer, R. W. (1982) · Diabetes · doi:10.2337/diab.31.9.830 · Cited by 317 · cited 1×
“1977), diabetes (Coleman et al. 1982), and systemic lupus erythematosus (Lucas et al.”
BackgroundLabrie, F. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.06.001 · Cited by 227
Suzuki, M., Wright, L. S., Marwah, P., Lardy, H. A., & Svendsen, C. N. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307325101 · Cited by 152
Mast, N., Annalora, A. J., Lodowski, D. T., Palczewski, K., Stout, C. D., & Pikuleva, I. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.188433 · Cited by 138
Cited by
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 865
Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome
Stener-Victorin, E., Padmanabhan, V., Walters, K. A., Campbell, R. E., Benrick, A., Giacobini, P., Dumesic, D. A., & Abbott, D. H. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa010 · Cited by 348
Estrogenic control of mitochondrial function
Klinge, C. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101435 · Cited by 293
Self-citationThe role of estrogen in cutaneous ageing and repair
Wilkinson, H. N., & Hardman, M. J. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.06.026 · Cited by 162
Androgenic potential of human fetal adrenals at the end of the first trimester
Savchuk, I., Morvan, M. L., Antignac, J. P., Gemzell-Danielsson, K., Le Bizec, B., Söder, O., & Svechnikov, K. (2017) · Endocrine Connections · doi:10.1530/ec-17-0085 · Cited by 20
Metadata
- Authors
- Prough, R. A., Clark, B. J., & Klinge, C. M.
- Venue
- Journal of Molecular Endocrinology
- Publisher
- Bioscientifica
- Published
- 2016-04
- Volume
- 56
- Issue
- 3
- Pages
- R139-R155
- ISSN
- 0952-5041 (ISSN-L)
- 1479-6813
- OpenAlex
- W2287079134
- Cited by
- 164
- References
- 12
- FWCI
- 14.72
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Novel mechanisms for DHEA action. https://app.cochat.ai/papers/10.1530/jme-16-0013
- The paper
- Prough, R. A., Clark, B. J., & Klinge, C. M. (2016). Novel mechanisms for DHEA action. Journal of Molecular Endocrinology. https://doi.org/10.1530/jme-16-0013
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
