The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Interplay between the immune system and adipose tissue in obesity
Open accessAbstract
Obesity is a major risk factor for metabolic disease, with white adipose tissue (WAT) inflammation emerging as a key underlying pathology. Alongside its major role in energy storage, WAT is an important endocrine organ, producing many bioactive molecules, termed adipokines, which not only serve as regulators of systemic metabolism, but also possess immunoregulatory properties. Furthermore, WAT contains a unique immune cell repertoire, including an accumulation of leukocytes that are rare in other locations. These include alternatively activated macrophages, invariant natural killer T cells, and regulatory T cells. Disruption of resident adipose leukocyte homeostasis contributes to obesity-associated inflammation and consequent metabolic disorder. Despite many recent advances in this new field of immuno-metabolism, fundamental questions of why and how inflammation arises as obesity develops are not yet fully understood. Exploring the distinct immune system of adipose tissue is fundamental to our understanding of the endocrine as well as immune systems. In this review, we discuss the roles of adipose tissue leukocytes in the transition to obesity and progression of inflammation and highlight potential anti-inflammatory therapies for combating obesity-related pathology.
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“Obesity promotes inflammatory pathways in visceral fat through adipocyte hypertrophy and hyperplasia and the accumulation of immune cells including macrophages, mast cells, and T lymphocytes producing pro-inflammatory cytokines (148–150).”
From Health Consequences of Sarcopenic Obesity: A Narrative Review (2020) · cites this paper as [149]
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Obesity induces a phenotypic switch in adipose tissue macrophage polarization
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“alpha melanocyte-stimulating hormone (alpha MSH)] [56-60].”
Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882
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Wu, S.-Y., Fu, T., Jiang, Y.-Z., & Shao, Z.-M. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01238-x · Cited by 863
Biological and Nutritional Properties of Palm Oil and Palmitic Acid: Effects on Health
Mancini, A., Imperlini, E., Nigro, E., Montagnese, C., Daniele, A., Orrù, S., & Buono, P. (2015) · Molecules · doi:10.3390/molecules200917339 · Cited by 600
“WAT produces adipokines that are responsible of chronic inflammation processes and are associated with obesity-related metabolic diseases [26].”
BackgroundMitochondrial dysfunction in obesity
de Mello, A. H., Costa, A. B., Engel, J. D. G., & Rezin, G. T. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.11.019 · Cited by 508
Metadata
- Authors
- Exley, M. A., Hand, L., O'Shea, D., & Lynch, L.
- Affiliations
- University College Dublin (IE)
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2014-09-16
- Volume
- 223
- Issue
- 2
- Pages
- R41-R48
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2145456795
- Cited by
- 242
- References
- 66
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 12 · 2023: 26 · 2022: 25 · 2021: 20 · 2020: 24 · 2019: 18 · 2018: 20 · 2017: 22 · 2016: 24 · 2015: 35
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Funders
- National Cancer Institute (P01CA017094, CA017094)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, white adipose tissue, adipose tissue inflammation, adipokines, M2 macrophages, invariant natural killer T cells, regulatory T cells, metabolic disorders, anti-inflammatory therapy
- MeSH terms
- Adipose Tissue, Animals, Eosinophils, Humans, Immune System, Inflammation, Lymphocytes, Macrophages, Obesity
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