Variations in serum FSH, LH and testosterone levels in male rats from birth to sexual maturity

LEE, V. W. K.; DE KRETSER, D. M.; HUDSON, B.; WANG, C.

doi:10.1530/jrf.0.0420121

Cited by 219Sperm and Testicular FunctionHypothalamic control of reproductive hormonesHormonal and reproductive studies

Variations in serum FSH, LH and testosterone levels in male rats from birth to sexual maturity

Open access

LEE, V. W. K., DE KRETSER, D. M., HUDSON, B., WANG, C.·1975·Reproduction

DOI 10.1530/jrf.0.0420121

Open this paper in CoChat — free account Open PDF

Abstract

Summary.: Serum LH, FSH and testosterone concentrations were measured by radioimmunoassays in male Sprague-Dawley rats from birth to 80 days of age. The levels of FSH were significantly elevated during the first 5 days of postnatal life. An abrupt decline in FSH concentrations occurred during this period, from levels of 800 ng/ml on Day 1 to levels of 300 ng/ml on Day 6. Subsequently, FSH levels fluctuated widely until about Days 30 to 45, when a secondary peak of FSH was observed. Thereafter, a decline in FSH levels to those found in adult rats occurred. This decline in FSH levels appears to coincide with the first release of mature spermatozoa from the germinal epithelium in the testis. During the first 30 days of postnatal life, LH and testosterone values appeared to be inversely related to each other and an LH peak and a nadir of testosterone levels was observed between Days 6 and 14 at a time corresponding to regression of the fetal generation of interstitial cells. A parallel rise in LH and testosterone levels occurred from Day 30 to sexual maturity and corresponded to the development of the adult generation of interstitial cells.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1530/jrf.0.0420121

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Average testosterone levels in the adult groups fell within the range of typical adult male levels.
“These levels fall within the range of typical adult male levels of circulating testosterone.33”
From Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression (2012) · cites this paper as [33]
The ‘Serum LH and testosterone levels’ section reports circulating testosterone above 230 ng/100 ml in male rats at 70–80 days of age. It provides a reference value for sexually mature rats, but does not define a typical adult male range or report the citing document’s group averages, so the claimed comparison is not established by this paper alone. (LLM, conf=0.78)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY
Greenwood, F., Hunter, W., & GLOVER, J. S. (1963) · Biochemical Journal · doi:10.1042/bj0890114 · Cited by 10,178 · see citing works
Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal.
Clermont, Y. (1972) · Physiological Reviews · doi:10.1152/physrev.1972.52.1.198 · Cited by 1,376 · see citing works
Serum LH and FSH During Sexual Maturation in the Male Rat: Effect of Castration and Cryptorchidism
Swerdloff, R. S., Walsh, P. C., Jacobs, H. S., & Odell, W. D. (1971) · Endocrinology · doi:10.1210/endo-88-1-120 · Cited by 214 · see citing works
Plasma Level of LH and FSH in Maturing Rats: Response to Hemigonadectomy
Ojeda, S. R., & RAMIREZ, V. D. (1972) · Endocrinology · doi:10.1210/endo-90-2-466 · Cited by 186 · see citing works
A generalized computer program for the treatment of data from competitive protein-binding assays including radioimmunoassays.
Burger, H., Vw, L., & Gc, R. (1972) · PubMed · Cited by 185 · see citing works
Ultrastructural features of the developing hypothalamo-hypophysial axis in the rat
Fink, G., & Smith, G. C. (1971) · Cell and Tissue Research · doi:10.1007/bf00324522 · Cited by 117 · see citing works
Monoamine fluorescence in the median eminence of foetal, neonatal and adult rats
Smith, G. C., & Simpson, R. W. (1970) · Cell and Tissue Research · doi:10.1007/bf00335377 · Cited by 61 · see citing works

Flagged first, then by citations

Sorted by citations

Chemical and Biological Characterization of the Inhibin Family of Protein Hormones
Vale, W., RIVIER, C. L., Hsueh, A. J. W., Campen, C. A., MEUNIER, H., Bicsak, T. A., Vaughan, J. M., CORRIGAN, A. Z., Bardin, W. C., Sawchenko, P. E., et al. (1988) · Elsevier eBooks · doi:10.1016/b978-0-12-571144-9.50005-3 · Cited by 457 · see citing works
Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant
Print, C. G., Loveland, K. L., Gibson, L., Meehan, T., Stylianou, A., Wreford, N. G., de Kretser, D., Metcalf, D., Köntgen, F., Adams, J. M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12424 · Cited by 335 · see citing works
Differentiation of the Adult Leydig Cell Population in the Postnatal Testis1
Mendis-Handagama, S. M. L. C., & Ariyaratne, H. B. S. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.3.660 · Cited by 322 · see citing works
When is a sex difference not a sex difference?
McCarthy, M. M., & Konkle, A. T. M. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.06.001 · Cited by 265 · see citing works
Brain Estradiol Content in Newborn Rats: Sex Differences, Regional Heterogeneity, and Possible de Novo Synthesis by the Female Telencephalon
Amateau, S. K., Alt, J., Stamps, C. L., & McCarthy, M. M. (2004) · Endocrinology · doi:10.1210/en.2003-1363 · Cited by 242 · see citing works
Developmental Changes in Testicular Gonadotropin Receptors: Plasma Gonadotropins and Plasma Testosterone in the Rat
Ketelslegers, J., Hetzel, W. D., Sherins, R. J., & Catt, K. J. (1978) · Endocrinology · doi:10.1210/endo-103-1-212 · Cited by 213 · see citing works
Male reproductive toxicity of lead in animals and humans. ASCLEPIOS Study Group.
Apostoli, P., Kiss, P., Porru, S., Bonde, J. P., & Vanhoorne, M. (1998) · Occupational and Environmental Medicine · doi:10.1136/oem.55.6.364 · Cited by 209 · see citing works
Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Activity in the Female Rat. A Focus on the EDSTAC Recommendations
Goldman, J., Laws, S., Balchak, S. K., Cooper, R., & Kavlock, R. (2000) · Critical Reviews in Toxicology · doi:10.1080/10408440091159185 · Cited by 200 · see citing works
Endocrine-Disrupting Chemicals: Prepubertal Exposures and Effects on Sexual Maturation and Thyroid Function in the Male Rat. A Focus on the EDSTAC Recommendations
Stoker, T., Parks, L., Gray, L., & Cooper, R. (2000) · Critical Reviews in Toxicology · doi:10.1080/10408440091159194 · Cited by 185 · see citing works
Development of cell types and of regional differences in the postnatal rat epididymis
Sun, E. L., & Flickinger, C. J. (1979) · American Journal of Anatomy · doi:10.1002/aja.1001540104 · Cited by 177 · see citing works
A Simple and Rapid in Vitro Bioassay for Inhibin*
Scott, R. S., Burger, H., & Quigg, H. (1980) · Endocrinology · doi:10.1210/endo-107-5-1536 · Cited by 167 · see citing works
Neurotoxicity of Anesthetic Drugs in the Developing Brain
Stratmann, G. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318232066c · Cited by 167 · see citing works
Regulation of gonadotrophin secretion in rams from birth to sexual maturity
Lee, V. W. K., CUMMING, I. A., KRETSER, D. M. D., Findlay, J. K., Hudson, B., & Keogh, E. J. (1976) · Reproduction · doi:10.1530/jrf.0.0460001 · Cited by 165 · see citing works
Self-citation
Changes in the Testis Interstitium of Sprague Dawley Rats from Birth to Sexual Maturity1
Ariyaratne, H. B. S., & Mendis-Handagama, S. M. L. C. (2000) · Biology of Reproduction · doi:10.1095/biolreprod62.3.680 · Cited by 151 · see citing works
Thyroid Hormone, Retinoic Acid, and Testosterone Suppress Proliferation and Induce Markers of Differentiation in Cultured Rat Sertoli Cells
Buzzard, J. J., Wreford, N. G., & Morrison, J. R. (2003) · Endocrinology · doi:10.1210/en.2003-0379 · Cited by 144 · see citing works
Effects of Experimental Cryptorchidism on the Ultrastructure and Function of the Sertoli Cell and Peritubular Tissue of the Rat Testis
KERR, J. B., Rich, K. A., & de Kretser, D. M. (1979) · Biology of Reproduction · doi:10.1095/biolreprod21.4.823 · Cited by 138 · see citing works
Postnatal Development of the Testis in the Rat
Picut, C. A., Remick, A. K., de Rijk, E. P. C. T., Simons, M. L., Stump, D. G., & Parker, G. A. (2014) · Toxicologic Pathology · doi:10.1177/0192623314547279 · Cited by 135 · see citing works
Molecular Characterization of Postnatal Development of Testicular Steroidogenesis in Luteinizing Hormone Receptor Knockout Mice
Zhang, F., Pakarainen, T., Zhu, F., POUTANEN, M. H., & Huhtaniemi, I. T. (2003) · Endocrinology · doi:10.1210/en.2003-1049 · Cited by 135 · see citing works
Follicle-Stimulating Hormone Induction of Ley dig Cell Maturation
KERR, J. B., & Sharpe, R. M. (1985) · Endocrinology · doi:10.1210/endo-116-6-2592 · Cited by 132 · see citing works
Age-Dependent Changes in Physiological Action, Content, and Immunostaining of Inhibin in Male Rats*
RIVIER, C. L., Cajander, S. B., Vaughan, J. M., Hsueh, A. J. W., & Vale, W. (1988) · Endocrinology · doi:10.1210/endo-123-1-120 · Cited by 131 · see citing works
Evaluation of Leydig Cell Function and Gonadotropin Binding in Unilateral and Bilateral Cryptorchidism: Evidence for Local Control of Leydig Cell Function by the seminiferous Tubule
Risbridger, G. P., KERR, J. B., & KRETSER, D. M. D. (1981) · Biology of Reproduction · doi:10.1095/biolreprod24.3.534 · Cited by 128 · see citing works
Cytology of the Testis and Intrinsic Control Mechanisms
KERR, J. B., Loveland, K. L., O’Bryan, M. K., & deKretser, D. M. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50023-3 · Cited by 127 · see citing works
Self-citation
A Quantitative Study of Spermatogenesis in the Developing Rat Testis
Zhengwei, Y., Wreford, N. G., & de Kretser, D. M. (1990) · Biology of Reproduction · doi:10.1095/biolreprod43.4.629 · Cited by 118 · see citing works
Morphometric analysis of the components of the neonatal and the adult rat testis interstitium
Mendis-Handagama, S. M. L. C., Risbridger, G. P., & KRETSER, D. M. D. (1987) · International Journal of Andrology · doi:10.1111/j.1365-2605.1987.tb00352.x · Cited by 117 · see citing works
The Development of Gonadotropin and Steroid Hormone Patterns in Male and Female Hamsters from Birth to Puberty*
Vomachka, A. J., & Greenwald, G. S. (1979) · Endocrinology · doi:10.1210/endo-105-4-960 · Cited by 116 · see citing works
Effects of organotin compounds on pubertal male rats
Grote, K., Stahlschmidt, B., Talsness, C. E., Gericke, C., Appel, K. E., & Chahoud, I. (2004) · Toxicology · doi:10.1016/j.tox.2004.05.003 · Cited by 114 · see citing works
The emergence of gonadal hormone influences on dopaminergic function during puberty
Kuhn, C., Johnson, M., Thomae, A., Luo, B., Simon, S. A., Zhou, G., & Walker, Q. D. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.10.015 · Cited by 113 · see citing works
Effects of Zinc Deficiency Upon Pituitary Function in Sexually Mature and Immature Male Rats
Root, A. W., DUCKETT, G. E., Sweetland, M., & Reiter, E. O. (1979) · Journal of Nutrition · doi:10.1093/jn/109.6.958 · Cited by 108 · see citing works
Lutropin/Choriogonadotropin Stimulate the Proliferation of Primary Cultures of Rat Leydig Cells through a Pathway that Involves Activation of the Extracellularly Regulated Kinase 1/2 Cascade
Shiraishi, K., & Ascoli, M. (2007) · Endocrinology · doi:10.1210/en.2007-0160 · Cited by 105 · see citing works
Inhibin production by sertoli cell cultures
Gac, F. L., & KRETSER, D. M. D. (1982) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(82)90141-1 · Cited by 102 · see citing works
Changes in Plasma Testosterone Levels During the Annual Reproductive Cycle of the Hibernating Bat, Myotis lucifugus lucifugus with a Survey of Plasma Testosterone Levels in Adult Male Vertebrates
Gustafson, A. W., & Shemesh, M. (1976) · Biology of Reproduction · doi:10.1093/biolreprod/15.1.9 · Cited by 101 · see citing works
Early Cerebrovascular Response to Head Injury in Immature and Mature Rats
GRUNDL, P. D., BIAGAS, K. V., Kochanek, P. M., Schiding, J. K., Barmada, M. A., & Nemoto, E. M. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.135 · Cited by 99 · see citing works
Changes in Circulating and Testicular Levels of Inhibin A and B and Activin A During Postnatal Development in the Rat
Buzzard, J. J., Loveland, K. L., O’Bryan, M. K., O’Connor, A. E., Bakker, M., Hayashi, T., Wreford, N. G., Morrison, J. R., & de Kretser, D. (2004) · Endocrinology · doi:10.1210/en.2003-1036 · Cited by 98 · see citing works
Dynamics of INSL3 Peptide Expression in the Rodent Testis1
Anand‐Ivell, R., Heng, K., Hafen, B., Setchell, B. P., & Ivell, R. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.109.077552 · Cited by 97 · see citing works
Novel molecular species of sphingomyelin containing 2-hydroxylated polyenoic very-long-chain fatty acids in mammalian testes and spermatozoa.
Robinson, B. S., Johnson, D. W., & Poulos, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46009-7 · Cited by 97 · see citing works
Differentiation of Adult Leydig Cells in the Neonatal Rat Testis Is Arrested by Hypothyroidism1
Mendis-Handagama, S. M. L. C., Ariyaratne, H. B. S., Manen, K. R. T. V., & Haupt, R. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.2.351 · Cited by 96 · see citing works
The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation
Shah, W., Khan, R., Shah, B., Khan, A. U., Dil, S., Liu, W., Wen, J., & Jiang, X. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.648141 · Cited by 94 · see citing works
Concentrations of circulating steroids in normal prepubertal and adult male and female humans, chimpanzees, rhesus monkeys, rats, mice, and hamsters: A literature survey
OVERPECK, J. G., Colson, S. H., Hohmann, J. R., Applestine, M. S., & Reilly, J. F. (1978) · Journal of Toxicology and Environmental Health · doi:10.1080/15287397809529700 · Cited by 93 · see citing works
Changes in testicular function induced by short‐term exposure of the rat testis to heat: further evidence for interaction of germ cells, Sertoli cells and Leydig cells
Jégou, B., Laws, A. O., & KRETSER, D. M. D. (1984) · International Journal of Andrology · doi:10.1111/j.1365-2605.1984.tb00781.x · Cited by 83 · see citing works
Androgen Modulation of Hippocampal Structure and Function
Atwi, S., McMahon, D., Scharfman, H. E., & MacLusky, N. J. (2014) · The Neuroscientist · doi:10.1177/1073858414558065 · Cited by 80 · see citing works
Mullerian Inhibiting Substance Ontogeny and its Modulation by Follicle-Stimulating Hormone in the Rat Testes*
Kuroda, T., Lee, M. M., Haqq, C. M., Powell, D., Manganaro, T. F., & Donahoe, P. K. (1990) · Endocrinology · doi:10.1210/endo-127-4-1825 · Cited by 80 · see citing works
Activation of the Lutropin/Choriogonadotropin Receptor Inhibits Apoptosis of Immature Leydig Cells in Primary Culture
Ping, T., Shiraishi, K., & Ascoli, M. (2009) · Endocrinology · doi:10.1210/en.2009-0207 · Cited by 76 · see citing works
Structural differentiation of the epithelial cells of the testicular excurrent duct system of rats during postnatal development
Hermo, L., Barin, K., & Robaire, B. (1992) · The Anatomical Record · doi:10.1002/ar.1092330205 · Cited by 76 · see citing works
Correlation between blood level of androgens and sexual behavior in male leopard frogs, Rana pipiens
Wada, M., Wingfield, J. C., & Gorbman, A. (1976) · General and Comparative Endocrinology · doi:10.1016/0016-6480(76)90008-3 · Cited by 73 · see citing works
An Assessment of Leydig Cell Function after Bilateral or Unilateral Efferent Duct Ligation: Further Evidence for Local Control of Leydig Cell Function*
Risbridger, G. P., KERR, J. B., Peake, R. A., & KRETSER, D. M. D. (1981) · Endocrinology · doi:10.1210/endo-109-4-1234 · Cited by 73 · see citing works
Temporal boundary of the sensitive period for hormonal organization of social play in juvenile rats.
Beatty, W. W., Dodge, A. M., Traylor, K. L., & Meaney, M. J. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90017-2 · Cited by 70 · see citing works
Identification, partial characterization and age-related changes of a cytoplasmic androgen receptor in the rat penis
Rajfer, J., Namkung, P. C., & Pétra, P. H. (1980) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(80)90064-3 · Cited by 67 · see citing works
The role of testosterone in spermatogenesis
O’Donnell, L., & McLachlan, R. I. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139003353.007 · Cited by 64 · see citing works
An inventory of the ethnoveterinary practices for reproductive disorders in cattle and buffaloes, Sargodha district of Pakistan
Dilshad, S. M. R., Najeeb-ur-Rehman, Iqbal, Z., Muhammad, G., Iqbal, A., & Ahmed, N. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.02.011 · Cited by 61 · see citing works
Effects of Experimental Cryptorchidism on Testicular Function in Adult Rats
Jégou, B., Risbridger, G. P., & de Kretser, D. M. (1983) · Journal of Andrology · doi:10.1002/j.1939-4640.1983.tb00726.x · Cited by 61 · see citing works
The effect of cryptorchidism and subsequent orchidopexy on testicular function in adult rats
Jégou, B., Laws, A. O., & KRETSER, D. M. D. (1983) · Reproduction · doi:10.1530/jrf.0.0690137 · Cited by 61 · see citing works
Prepubertal Changes in the Hypothalamic-Pituitary Axis of Holstein Bulls1
AMANN, R. P., Wise, M. E., Glass, J. D., & Nett, T. M. (1986) · Biology of Reproduction · doi:10.1095/biolreprod34.1.71 · Cited by 59 · see citing works
Developmental stages of fetal-type Leydig cells in prepubertal rats
Kuopio, T., Tapanainen, J. S., Pelliniemi, L. J., & Huhtaniemi, I. T. (1989) · Development · doi:10.1242/dev.107.2.213 · Cited by 58 · see citing works
Hormonal Regulation of Sertoli Cell Differentiation1
Chemes, H., Dym, M., & Raj, H. (1979) · Biology of Reproduction · doi:10.1095/biolreprod21.1.251 · Cited by 58 · see citing works
Maturation of the pituitary—gonadal system in the male rat
Piacsek, B. E., & Goodspeed, M. P. (1978) · Reproduction · doi:10.1530/jrf.0.0520029 · Cited by 57 · see citing works
Lead poisoning and reproduction: Effects on pituitary and serum gonadotropins in neonatal rats
Petrusz, P., Weaver, C. M., Grant, L. D., Mushak, P., & Krigman, M. R. (1979) · Environmental Research · doi:10.1016/0013-9351(79)90063-x · Cited by 56 · see citing works
Development of the blood‐testis barrier and changes in vascular permeability at puberty in rats
Setchell, B. P., Pöllänen, P., & Zupp, J. L. (1988) · International Journal of Andrology · doi:10.1111/j.1365-2605.1988.tb00997.x · Cited by 56 · see citing works
A switch in Sertoli cell responsiveness to FSH may be responsible for robust onset of germ cell differentiation during prepubartal testicular maturation in rats
Bhattacharya, I., Pradhan, B. S., Sarda, K., Gautam, M., Basu, S., & Majumdar, S. S. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00293.2012 · Cited by 54 · see citing works
The Effects of Caffeine on Sleep and Maturational Markers in the Rat
Olini, N., Kurth, S., & Huber, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072539 · Cited by 50 · see citing works
Testosterone influences spatial strategy preferences among adult male rats
Spritzer, M. D., Fox, E., Larsen, G. D., Batson, C. G., Wagner, B. A., & Maher, J. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.03.018 · Cited by 47 · see citing works
Seminiferous Tubule Fluid and Interstitial Fluid Production. I. Effects of Age and Hormonal Regulation in Immature Rats
Jégou, B., Gac, F. L., & de Kretser, D. (1982) · Biology of Reproduction · doi:10.1095/biolreprod27.3.590 · Cited by 50 · see citing works
Differential effects of bisphenol A and estradiol on rat spermatogenesis’ establishment
Brouard, V., Guénon, I., Bouraïma-Lelong, H., & Delalande, C. (2016) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.05.003 · Cited by 48 · see citing works
Developmental expression and androgenic regulation of the mRNA for major secretory proteins of the rat epididymis
Brooks, D. E. (1987) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(87)90192-4 · Cited by 48 · see citing works
Plasticity of basal cells during postnatal development in the rat epididymis
Shum, W. W., Hill, E., Brown, D., & Breton, S. (2013) · Reproduction · doi:10.1530/rep-12-0510 · Cited by 44 · see citing works
Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression
Forbes-Lorman, R. M., Rautio, J. J., Kurian, J. R., Auger, A. P., & Auger, C. J. (2012) · Epigenetics · doi:10.4161/epi.7.3.19265 · Cited by 43 · see citing works
Temporal changes in rat Leydig cell function after the induction of bilateral cryptorchidism
Risbridger, G. P., KERR, J. B., Peake, R. A., Rich, K. A., & KRETSER, D. M. D. (1981) · Reproduction · doi:10.1530/jrf.0.0630415 · Cited by 43 · see citing works
Age Related Changes in Serum Levels of Gonadotropins and Testosterone in Infantile Male Rhesus Monkeys1
Frawley, L. S., & Neill, J. D. (1979) · Biology of Reproduction · doi:10.1095/biolreprod20.5.1147 · Cited by 43 · see citing works
Postnatal differentiation of leydig cells in the rabbit testis
Gondos, B., Renston, R. H., & Goldstein, D. A. (1976) · American Journal of Anatomy · doi:10.1002/aja.1001450203 · Cited by 42 · see citing works
Effects of Thyroid and Luteinizing Hormones on the Onset of Precursor Cell Differentiation into Leydig Progenitor Cells in the Prepubertal Rat Testis1
Ariyaratne, H. B. S., Mason, J. I., & Mendis-Handagama, S. M. L. C. (2000) · Biology of Reproduction · doi:10.1095/biolreprod63.3.898 · Cited by 40 · see citing works
Seasonally and experimentally induced changes in testicular function of the Australian bush rat ( Rattus fuscipes )
IRBY, D. C., KERR, J. B., Risbridger, G. P., & de Kretser, D. M. (1984) · Reproduction · doi:10.1530/jrf.0.0700657 · Cited by 40 · see citing works
Mechanism of Action of Inhibin
Scott, R. S., & Burger, H. (1981) · Biology of Reproduction · doi:10.1095/biolreprod24.3.541 · Cited by 40 · see citing works
Reproductive role of miRNA in the hypothalamic-pituitary axis
Cao, C., Ding, Y., Kong, X., Feng, G., Xiang, W., Chen, L., Yang, F., Zhang, K., Chu, M., Wang, P., et al. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.01.008 · Cited by 39 · see citing works
Changes in Testicular Inhibin after a Single Episode of Heating of Rat Testes*
Au, C. L., Robertson, D. M., & KRETSER, D. M. D. (1987) · Endocrinology · doi:10.1210/endo-120-3-973 · Cited by 39 · see citing works
Administration of Estradiol-3-Benzoate Down-Regulates the Expression of Testicular Steroidogenic Enzyme Genes for Testosterone Production in the Adult Rat.
Sakaue, M., Ishimura, R., Kurosawa, S., Fukuzawa, N., Kurohmaru, M., Hayashi, Y., Tohyama, C., & Ohsako, S. (2002) · Journal of Veterinary Medical Science · doi:10.1292/jvms.64.107 · Cited by 38 · see citing works
Basement membrane and epithelial features of fetal-type Leydig cells in rat and human testis
Kuopio, T., Paranko, J., & Pelliniemi, L. J. (1989) · Differentiation · doi:10.1111/j.1432-0436.1989.tb00599.x · Cited by 38 · see citing works
The role of endogenous opioids in the blockade of reproductive function in the rat following exposure to acute stress.
Hulse, G., & Coleman, G. J. (1983) · Pharmacology, Biochemistry and Behavior · doi:10.1016/0091-3057(83)90083-7 · Cited by 38 · see citing works
Hormonal Control of Spermatogenesis
Weinbauer, G. F., & Nieschlag, E. (1993) · Elsevier eBooks · doi:10.1016/b978-0-08-091764-1.50008-8 · Cited by 37 · see citing works
Prenatal Morphine Exposure Induces Age-Related Changes in Seizure Susceptibility in Male Rats
Vathy, I. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00048-3 · Cited by 37 · see citing works
A Model for Pharmacokinetics and Physiological Feedback among Hormones of the Testicular-Pituitary Axis in Adult Male Rats: A Framework for Evaluating Effects of Endocrine Active Compounds
Barton, H. A., & Andersen, M. E. (1998) · Toxicological Sciences · doi:10.1006/toxs.1998.2538 · Cited by 36 · see citing works
The mRNAs for the Steroid 5α‐Reductase Isozymes, Types 1 and 2, Are Differentially Regulated in the Rat Epididymis
Viger, R. S., & Robaire, B. (1996) · Journal of Andrology · doi:10.1002/j.1939-4640.1996.tb00583.x · Cited by 36 · see citing works
Estrogen-dependent hippocampal wiring as a risk factor for age-related dementia in women
Torromino, G., Maggi, A. C., & Leonibus, E. D. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101895 · Cited by 34 · see citing works
Measurement of Inhibin and an Index of Inhibin Production by Rat Testes during Postnatal Development1
Au, C. L., Robertson, D. M., & KRETSER, D. M. D. (1986) · Biology of Reproduction · doi:10.1095/biolreprod35.1.37 · Cited by 35 · see citing works
Androgen Supplementation in Rats Increases the Inflammatory Response and Prolongs Urethral Healing
Hofer, M. D., Cheng, E. Y., Bury, M. I., Xu, W., Hong, S. J., Kaplan, W. E., & Sharma, A. K. (2015) · Urology · doi:10.1016/j.urology.2014.11.025 · Cited by 34 · see citing works
Testosterone Changes Bladder and Kidney Structure in Juvenile Male Rats
Shortliffe, L. M. D., Ye, Y., Behr, B. R., & Wang, B. (2014) · The Journal of Urology · doi:10.1016/j.juro.2014.01.012 · Cited by 34 · see citing works
Mechanisms of Hormonal Regulation of Sertoli Cell Development and Proliferation: A Key Process for Spermatogenesis
Escott, G. M., da Rosa, L., & Loss, E. D. S. (2015) · Current Molecular Pharmacology · doi:10.2174/1874467208666150126155032 · Cited by 34 · see citing works
A Sertoli cell-secreted paracrine factor(s) stimulates proliferation and inhibits steroidogenesis of rat Leydig cells
Wu, N., & Murono, E. P. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90191-0 · Cited by 34 · see citing works
Inhibin is absent from azoospermic semen of infertile men
Scott, R. S., & Burger, H. (1980) · Nature · doi:10.1038/285246a0 · Cited by 33 · see citing works
Functional development of sex accessory organs of the male rat. Use of oestradiol benzoate to identify the neonatal period as critical for development of normal protein-synthetic and secretory capabilities
Higgins, S. J., Brooks, D. E., Fuller, F. M., Jackson, P. J., & Smith, S. E. (1981) · Biochemical Journal · doi:10.1042/bj1940895 · Cited by 32 · see citing works
Impaired testosterone biosynthesis in cryptorchidism
Farrer, J. H., Sikka, S. C., Xie, H. W., Constantinide, D., & Rajfer, J. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48689-9 · Cited by 31 · see citing works
Age dependent changes in the sperm population and fertility in the male rat
Saksena, S. K., Lau, I. F., & Chang, M. C. (1979) · Experimental Aging Research · doi:10.1080/03610737908257211 · Cited by 29 · see citing works
Studies of the Structure and Function of the Sertoli Cell in a Seasonally Breeding Rodent
Hodgson, Y., IRBY, D. C., KERR, J. B., & KRETSER, D. M. D. (1979) · Biology of Reproduction · doi:10.1095/biolreprod21.5.1091 · Cited by 29 · see citing works
Developmental pattern of testosterone production by the rat testis
Paz, G. F., Winter, J. S. D., Reyes, F. I., & Faiman, C. (1980) · Steroids · doi:10.1016/0039-128x(80)90050-1 · Cited by 29 · see citing works
Loss of predator aversion in female rats after Toxoplasma gondii infection is not dependent on ovarian steroids
Abdulai-Saiku, S., & Vyas, A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.04.005 · Cited by 27 · see citing works
The Effects of Chronic Human Chorionic Gonadotropin Treatment on Leydig Cell Function*
Risbridger, G. P., Robertson, D. M., & KRETSER, D. M. D. (1982) · Endocrinology · doi:10.1210/endo-110-1-138 · Cited by 27 · see citing works
The androgenic control of the composition of the rat epididymis determined by efferent duct ligation or castration
Brooks, D. E. (1977) · Reproduction · doi:10.1530/jrf.0.0490383 · Cited by 27 · see citing works
Expression of 4-ene steroid 5 alpha-reductase messenger ribonucleic acid in the rat epididymis during postnatal development
Viger, R. S., & Robaire, B. (1992) · Endocrinology · doi:10.1210/en.131.3.1534 · Cited by 27 · see citing works
Development of secretory protein synthesis in the seminal vesicles and ventral prostate of the male rat
Higgins, S. J., Smith, S. E., & Wilson, J. J. (1982) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(82)90062-4 · Cited by 27 · see citing works
Serum inhibin, FSH, LH and testosterone levels and testicular inhibin content in beef bulls from birth to puberty
Miyamoto, A., UMEZU, M., Ishii, S., Furusawa, T., MASAKI, J., Hasegawa, Y., & Ohta, M. (1989) · Animal Reproduction Science · doi:10.1016/0378-4320(89)90082-1 · Cited by 26 · see citing works
Effects of developmental hyperserotonemia on juvenile play behavior, oxytocin and serotonin receptor expression in the hypothalamus are age and sex dependent
Madden, A. M. K., & Zup, S. L. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.01.036 · Cited by 26 · see citing works
Prenatal morphine exposure alters susceptibility to bicuculline seizures in a sex- and age-specific manner
Schindler, C. J., Velı́šková, J., Šlamberová, R., & Vathy, I. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(00)00031-6 · Cited by 26 · see citing works

THE ONSET AND ESTABLISHMENT OF SPERMATOGENESIS IN RATS IN RELATION TO GONADOTROPHIN AND TESTOSTERONE LEVELS
de Jong, F. H., & Sharpe, R. M. (1977) · Journal of Endocrinology · doi:10.1677/joe.0.0750197 · Cited by 72 · see citing works
Regulation of gonadotrophin secretion in rams from birth to sexual maturity
Lee, V. W. K., CUMMING, I. A., KRETSER, D. M. D., Findlay, J. K., Hudson, B., & Keogh, E. J. (1976) · Reproduction · doi:10.1530/jrf.0.0460001 · Cited by 165 · see citing works
Self-citation
AGE-DEPENDENT CHANGES IN PITUITARYGONADAL RELATIONSHIPS
Labhsetwar, A. P. (1970) · Reproduction · doi:10.1530/jrf.0.0210407 · Cited by 8 · see citing works
Maturation of the pituitary—gonadal system in the male rat
Piacsek, B. E., & Goodspeed, M. P. (1978) · Reproduction · doi:10.1530/jrf.0.0520029 · Cited by 57 · see citing works
Developmental Changes in Testicular Gonadotropin Receptors: Plasma Gonadotropins and Plasma Testosterone in the Rat
Ketelslegers, J., Hetzel, W. D., Sherins, R. J., & Catt, K. J. (1978) · Endocrinology · doi:10.1210/endo-103-1-212 · Cited by 213 · see citing works

Authors: LEE, V. W. K., DE KRETSER, D. M., HUDSON, B., & WANG, C.
Affiliations: The University of Melbourne (AU)
Venue: Reproduction
Publisher: Oxford University Press (OUP)
Published: 1975-01-01
Volume: 42
Issue: 1
Pages: 121-126
ISSN: 1470-1626 (ISSN-L)
1741-7899
DOI: 10.1530/jrf.0.0420121
OpenAlex: W2033259793
Cited by: 219
References: 7
Citations by year: 2025: 1 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 7
FWCI: 4.87
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Reproduction (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: luteinizing hormone, follicle-stimulating hormone, testosterone, postnatal development, male rats, sexual maturation, Leydig cell development, spermiation, interstitial cells, gonadotropins
MeSH terms: Age Factors, Animals, Antibodies, Follicle Stimulating Hormone, Iodine Radioisotopes, Luteinizing Hormone, Male, Radioimmunoassay, Spermatozoa, Testosterone, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Variations in serum FSH, LH and testosterone levels in male rats from birth to sexual maturity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks