The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Chromatoid body and small RNAs in male germ cells
Open accessAbstract
The chromatoid body (CB) is a germ granule in the cytoplasm of postmeiotic haploid round spermatids that is loaded with RNA and RNA-binding proteins. Following the discovery of small non-coding RNA-mediated gene regulation and the identification of PIWI-interacting RNAs (piRNAs) that have crucial roles in germ line development, the function of the CB has slowly begun to be revealed. Male germ cells utilise small RNAs to control the complex and specialised process of sperm production. Several microRNAs have been identified during spermatogenesis. In addition, a high number of piRNAs are present both in embryonic and postnatal male germ cells, with their expression being impressively induced in late meiotic cells and haploid round spermatids. At postmeiotic stage of germ cell differentiation, the CB accumulates piRNAs and proteins of piRNA machinery, as well as several other proteins involved in distinct RNA regulation pathways. All existing evidence suggests a role for the CB in mRNA regulation and small RNA-mediated gene control, but the mechanisms remain uncharacterised. In this review, we summarise the current knowledge of the CB and its association with small RNA pathways.
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Cites
Most mammalian mRNAs are conserved targets of microRNAs
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The widespread regulation of microRNA biogenesis, function and decay
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A germline-specific class of small RNAs binds mammalian Piwi proteins
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A novel class of small RNAs bind to MILI protein in mouse testes
Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516
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Cited by
Nott, T. J., Petsalaki, E., Farber, P., Jervis, D., Fussner, E., Plochowietz, A., Craggs, T. D., Bazett-Jones, D. P., Pawson, T., Forman-Kay, J. D., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.01.013 · Cited by 1,803
Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm
Sharma, U., Sun, F., Conine, C. C., Reichholf, B., Kukreja, S., Herzog, V. A., Ameres, S. L., & Rando, O. J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.023 · Cited by 429
Molecular insights into transgenerational non-genetic inheritance of acquired behaviours
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Metadata
- Authors
- Meikar, O., Da Ros, M., Korhonen, H., & Kotaja, N.
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08-01
- Volume
- 142
- Issue
- 2
- Pages
- 195-209
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- OpenAlex
- W2159708426
- Cited by
- 167
- References
- 8
- FWCI
- 13.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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