The DOI matches its Crossref record; 132 of the 134 references it cites were found in a registry or an index.
Reproductive consequences of developmental phytoestrogen exposure
Open accessAbstract
Phytoestrogens, estrogenic compounds derived from plants, are ubiquitous in human and animal diets. These chemicals are generally much less potent than estradiol but act via similar mechanisms. The most common source of phytoestrogen exposure to humans is soybean-derived foods that are rich in the isoflavones genistein and daidzein. These isoflavones are also found at relatively high levels in soy-based infant formulas. Phytoestrogens have been promoted as healthy alternatives to synthetic estrogens and are found in many dietary supplements. The aim of this review is to examine the evidence that phytoestrogen exposure, particularly in the developmentally sensitive periods of life, has consequences for future reproductive health.
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“Evidence of the endocrine disrupting properties of GEN dates back decades, and soy is so well recognized as a hormonally active food, that it is frequently advertised and promoted as such (15, 111–115).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [113]
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Křížová, L., Dadáková, K., Kašparovská, J., & Kašparovský, T. (2019) · Molecules · doi:10.3390/molecules24061076 · Cited by 714
Phytoestrogens and their effects
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Metadata
- Authors
- Jefferson, W. N., Patisaul, H. B., & Williams, C. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Williams, Carmen J
- Venue
- Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-03-01
- Volume
- 143
- Issue
- 3
- Pages
- 247-260
- ISSN
- 1470-1626 (ISSN-L)
- 1741-7899
- PMC
- PMC3443604
- OpenAlex
- W2119382214
- Cited by
- 181
- References
- 134
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 8 · 2023: 11 · 2022: 9 · 2021: 18 · 2020: 18 · 2019: 11 · 2018: 16 · 2017: 11 · 2016: 20 · 2015: 10 · 2014: 19 · 2013: 11 · 2012: 5
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1z01es102405-01)
- National Institute of Environmental Health Sciences (R01ES016001, Z01-ES102405, ZIAES102405)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- phytoestrogens, isoflavones, genistein, daidzein, soybean, soy-based infant formula, early life exposure, reproductive health, endocrine disruptors, dietary supplements, estrogenic compounds
- MeSH terms
- Animals, Child Development, Diet, Humans, Infant, Infant Food, Infant, Newborn, Reproduction, Infant Formula, Phytoestrogens
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