Antioxidants and Chronic Obstructive Pulmonary Disease

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311 · see citing works

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary

Vogelmeier, C. F., Criner, G. J., Martinez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0218pp · Cited by 3,187 · see citing works

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

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Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Soriano, J. B., Abajobir, A. A., Abate, K. H., Abera, S. F., Agrawal, A., Ahmed, M. B., Aichour, A. N., Aichour, I., Aichour, M. T. E., Alam, K., et al. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30293-x · Cited by 2,552 · see citing works

Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea

Pryor, W. A., & Stone, K. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb39148.x · Cited by 1,154 · see citing works

Normal alveolar epithelial lining fluid contains high levels of glutathione

Cantin, A. M., North, S. L., Hubbard, R. C., & Crystal, R. G. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.1.152 · Cited by 797 · see citing works

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary

Vogelmeier, C. F., Criner, G. J., Martínez, F. J., Anzueto, A., Barnes, P. J., Bourbeau, J., Celli, B. R., Chen, R., Decramer, M., Fabbri, L. M., et al. (2017) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2017.02.001 · Cited by 758 · see citing works

Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

Rushworth, G. F., & Megson, I. L. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.09.006 · Cited by 724 · see citing works

Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline

Wedzicha, J. A., Miravitlles, M., Hurst, J. R., Calverley, P. M. A., Albert, R. K., Anzueto, A., Criner, G. J., Papi, A. A., Rabe, K. F., Comas, D. R., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.00791-2016 · Cited by 688 · see citing works

Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine

Ohta, S. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.04.006 · Cited by 527 · see citing works

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

Lv, H., Liu, Q., Wen, Z., Feng, H., Deng, X., & Ci, X. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.001 · Cited by 424 · see citing works

Myeloperoxidase of the leucocyte of normal human blood. I. Content and localization

Schultz, J., & Kaminker, K. (1962) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(62)90321-1 · Cited by 403 · see citing works

Oxidative Stress and Apoptosis Interact and Cause Emphysema Due to Vascular Endothelial Growth Factor Receptor Blockade

Tuder, R. M., Zhen, L., Cho, C. Y., Tarasevičienė-Stewart, L., Kasahara, Y., Salvemini, D., Voelkel, N. F., & Flores, S. C. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0228oc · Cited by 391 · see citing works

Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar.

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Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study

Zheng, J.-P., Kang, J., Huang, S., Chen, P., Yao, W.-Z., Yang, L., Bai, C., Wang, C., Wang, C., Chen, B.-Y., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60869-7 · Cited by 357 · see citing works

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804333106 · Cited by 346 · see citing works

Nrf2‐deficient mice are highly susceptible to cigarette smoke‐induced emphysema

Iizuka, T., Ishii, Y., Itoh, K., Kiwamoto, T., Kimura, T., Matsuno, Y., Morishima, Y., Hegab, A. E., Homma, S., Nomura, A., et al. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00905.x · Cited by 336 · see citing works

Prevention of Acute Exacerbations of COPD

Criner, G. J., Bourbeau, J., Diekemper, R. L., Ouellette, D. R., Goodridge, D. M., Hernandez, P., Curren, K., Balter, M. S., Bhutani, M., Camp, P. G., et al. (2014) · CHEST Journal · doi:10.1378/chest.14-1676 · Cited by 290 · see citing works

The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review

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Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial

Zheng, J.-P., Wen, F., Bai, C., Huan-ying, W., Kang, J., Chen, P., Yao, W.-Z., Ma, L.-J., Li, X., Raiteri, L., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70286-8 · Cited by 259 · see citing works

Consequences of Total and Subtotal Myeloperoxidase Deficiency: Risk or Benefit ?

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ANTIOXIDANT PROTECTION: A FUNCTION OF TRACHEOBRONCHIAL AND GASTROINTESTINAL MUCUS

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Altered oxidative metabolic responses in vitro of alveolar macrophages from asymptomatic cigarette smokers.

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The Anti-inflammatory Effects of Selenium Are Mediated through 15-Deoxy-Δ12,14-prostaglandin J2 in Macrophages

Vunta, H., Davis, F. B., Palempalli, U. M. D., Bhat, D., Arner, R. J., Thompson, J. T., Peterson, D. G., Reddy, C. C., & Prabhu, K. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703075200 · Cited by 211 · see citing works

Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis

Cazzola, M., Calzetta, L., Page, C., Jardim, J., Chuchalin, A., Rogliani, P., & Matera, M. G. (2015) · European Respiratory Review · doi:10.1183/16000617.00002215 · Cited by 208 · see citing works

High-Dose N-Acetylcysteine in Stable COPD

Tse, H. N., Raiteri, L., Wong, K. Y., Yee, K. S., Ng, L. Y., Wai, K. Y., Loo, C. K., & Chan, M. (2013) · CHEST Journal · doi:10.1378/chest.12-2357 · Cited by 189 · see citing works

NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice

Segal, B. H., Han, W., Bushey, J. J., Joo, M., Bhatti, Z., Feminella, J., Dennis, C. G., Vethanayagam, R. R., Yull, F. E., Capitano, M. L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009631 · Cited by 180 · see citing works

Role of myeloperoxidase in the respiratory burst of human neutrophils

Nauseef, W., Metcalf, J., & Root, R. (1983) · Blood · doi:10.1182/blood.v61.3.483.483 · Cited by 175 · see citing works

Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline

Wedzicha, J. A., Calverley, P. M. A., Albert, R. K., Anzueto, A., Criner, G. J., Hurst, J. R., Miravitlles, M., Papi, A. A., Rabe, K. F., Comas, D. R., et al. (2017) · doi:10.7892/boris.105695 · Cited by 168 · see citing works

Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline

Wedzicha, J. A., Calverley, P. M. A., Albert, R. K., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.02265-2016 · Cited by 164 · see citing works

The role of nuclear factor-erythroid 2 related factor 2 (Nrf-2) in the protection against lung injury

Zhao, H., Eguchi, S., Alam, A., & Ma, D. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00449.2016 · Cited by 161 · see citing works

Cigarette Smoke-Induced Changes to Alveolar Macrophage Phenotype and Function Are Improved by Treatment with Procysteine

Hodge, S. J., Matthews, G. M., Mukaro, V. R., Ahern, J., Shivam, A., Hodge, G. L., Holmes, M., Jersmann, H. P. A., & Reynolds, P. N. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0459oc · Cited by 160 · see citing works

Cigarette smoke and CFTR: implications in the pathogenesis of COPD

Rab, A., Rowe, S. M., Raju, S. V., Bebők, Z., Matalon, S., & Collawn, J. F. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00039.2013 · Cited by 159 · see citing works

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.

Hubbard, R. C., Ogushi, F., Fells, G. A., Cantin, A. M., Jallat, S., Courtney, M., & Crystal, R. G. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113204 · Cited by 157 · see citing works

The association between oxidative stress and obstructive lung impairment in patients with COPD

Kluchová, Z., Petrášová, D., Joppa, P., Dorková, Z., & Tkáčová, R. (2007) · Physiological Research · doi:10.33549/physiolres.930884 · Cited by 149 · see citing works

Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men

Kałuża, J., Larsson, S. C., Orsini, N., Lindén, A., & Wolk, A. (2017) · Thorax · doi:10.1136/thoraxjnl-2015-207851 · Cited by 147 · see citing works

15-Deoxy-Δ12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors

Kim, E. H., & Surh, Y. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.030 · Cited by 145 · see citing works

Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease

Poole, P., Chong, J., & Cates, C. J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001287.pub5 · Cited by 141 · see citing works

Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study

Negro, R. W. D., Wedzicha, J. A., Iversen, M., Fontana, G. A., Page, C. P., Cicero, A. F. G., Pozzi, E., & Calverley, P. M. A. (2017) · European Respiratory Journal · doi:10.1183/13993003.00711-2017 · Cited by 134 · see citing works

Lower respiratory tract iron burden is increased in association with cigarette smoking.

Thompson, A. B., Bohling, T., Heires, A. J., Linder, J., & Rennard, S. I. (1991) · PubMed · Cited by 128 · see citing works

Oxidation of Z α1-Antitrypsin by Cigarette Smoke Induces Polymerization

Alam, S., Li, Z., Janciauskiene, S. M., & Mahadeva, R. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0328oc · Cited by 126 · see citing works

Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease

Poole, P., Sathananthan, K., & Normansell, R. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001287.pub6 · Cited by 126 · see citing works

Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial

Wise, R. A., Holbrook, J. T., Criner, G., Sethi, S., Rayapudi, S., Sudini, K. R., Sugar, E. A., Burke, A., Thimmulappa, R., Singh, A., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0163716 · Cited by 124 · see citing works

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action

Jaquet, V., Marcoux, J., Forest, É., Leidal, K. G., McCormick, S. J., Westermaier, Y., Perozzo, R., Plastre, O., Fioraso-Cartier, L., Diebold, B. A., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01439.x · Cited by 120 · see citing works

Pharmacological antioxidant strategies as therapeutic interventions for COPD

Rahman, I. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.004 · Cited by 117 · see citing works

Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro

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Pharmacological and Dietary Antioxidant Therapies for Chronic Obstructive Pulmonary Disease

Biswas, S., Hwang, J. W., Kirkham, P., & Rahman, I. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320120004 · Cited by 112 · see citing works

Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant 1 11The research described in this article has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency and approved for publication. Approval does not signify that the contents necessarily reflect the views and the policies of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

Smith, K. R., Uyeminami, D. L., Kodavanti, U. P., Crapo, J. D., Chang, L., & Pinkerton, K. E. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01003-1 · Cited by 110 · see citing works

Late Intervention with a Myeloperoxidase Inhibitor Stops Progression of Experimental Chronic Obstructive Pulmonary Disease

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Oxidant stress suppresses CFTR expression

Cantin, A. M., Bilodeau, G., Ouellet, C., Liao, J., & Hanrahan, J. W. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00070.2005 · Cited by 107 · see citing works

The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: the EQUALIFE Study.

Moretti, M., Bottrighi, P., Dallari, R., Porto, R. D., Dolcetti, A., Grandi, P., Garuti, G., Guffanti, E. E., Roversi, P., Gugliemo, M. D., et al. (2004) · PubMed · Cited by 102 · see citing works

Cigarette tar causes single-strand breaks in DNA

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Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

Oostwoud, L. C., Gunasinghe, P., Seow, H. J., Ye, J. M., Selemidis, S., Bozinovski, S., & Vlahos, R. (2016) · Scientific Reports · doi:10.1038/srep20983 · Cited by 90 · see citing works

Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice

Duong, C., Seow, H. J., Bozinovski, S., Crack, P. J., Anderson, G. P., & Vlahos, R. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00038.2010 · Cited by 89 · see citing works

Inhibition of airway inflammation and hyperreactivity by an antioxidant mimetic

Chang, L., & Crapo, J. D. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00919-x · Cited by 88 · see citing works

Staphylococcus aureus, phagocyte NADPH oxidase and chronic granulomatous disease

Buvelot, H., Posfay-Barbe, K. M., Linder, P., Schrenzel, J., & Krause, K. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw042 · Cited by 88 · see citing works

Differential Effects of Ebselen on Neutrophil Recruitment, Chemokine, and Inflammatory Mediator Expression in a Rat Model of Lipopolysaccharide-Induced Pulmonary Inflammation

Haddad, E., McCluskie, K., Birrell, M. A., Dabrowski, D., Pecoraro, M., Underwood, S., Chen, B., Sanctis, G. T. D., Webber, S. E., Foster, M. L., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.974 · Cited by 78 · see citing works

Inflammation and repeated infections in CGD: two sides of a coin

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Prevention of Acute Exacerbations of Chronic Obstructive Bronchitis with Carbocysteine Lysine Salt Monohydrate: A Multicenter, Double-Blind, Placebo-Controlled Trial

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Airway Epithelium and Mucus

Adler, K. B., & Li, Y. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.4.f214 · Cited by 71 · see citing works

Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells

Seo, W. Y., Goh, A. R., Ju, S. M., Song, H. Y., Kwon, D.-J., Jun, J., Kim, B. C., Choi, S. Y., & Park, J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.03.053 · Cited by 70 · see citing works

N-acetylcysteine in COPD: why, how, and when?

Sanguinetti, C. M. (2015) · Multidisciplinary Respiratory Medicine · doi:10.1186/s40248-016-0039-2 · Cited by 66 · see citing works

Selenoprotein S/SEPS1 Modifies Endoplasmic Reticulum Stress in Z Variant α1-Antitrypsin Deficiency

Kelly, E., Greene, C. M., Carroll, T. P., McElvaney, N. G., & O'Neill, S. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.006288 · Cited by 65 · see citing works

The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection

Traboulsi, H., Cloutier, A., Boyapelly, K., Bonin, M., Marsault, É., Cantin, A. M., & Richter, M. V. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01098-15 · Cited by 64 · see citing works

Systemic markers of the redox balance in chronic obstructive pulmonary disease

Santos, C., Oliveira, A. L., Viegas-Crespo, A. M., Vicente, L., Barreiros, M. A., Monteiro, P. H., Pinheiro, T., & de Almeida, A. B. (2004) · Biomarkers · doi:10.1080/13547500400024768 · Cited by 64 · see citing works

CARBOCISTEINE REDUCES FREQUENCY OF COMMON COLDS AND EXACERBATIONS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Yasuda, H., Yamaya, M., Sasaki, T., Inoue, D., Nakayama, K., Tomita, N., Yoshida, M., & Sasaki, H. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00592_9.x · Cited by 63 · see citing works

Release of iron from ferritin by aqueous extracts of cigarette smoke

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Ebselen suppresses late airway responses and airway inflammation in guinea pigs

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The Bronchitis Randomized On NAC Cost-Utility Study (BRONCUS): hypothesis and design

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The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: A meta-analysis and systematic review

Fowdar, K., Chen, H., He, Z., Zhang, J., Zhong, X.-N., Zhang, J., Li, M., & Bai, J. (2017) · Heart & Lung · doi:10.1016/j.hrtlng.2016.12.004 · Cited by 55 · see citing works

The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data

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Role of thioredoxin in lung disease

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Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress

Tollefson, A. K., Oberley‐Deegan, R. E., Butterfield, K., Nicks, M. E., Weaver, M. R., Remigio, L. K., deCsesznak, J., Chu, H. W., Bratton, D. L., Riches, D. W. H., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.022 · Cited by 47 · see citing works

CARBOCISTEINE IMPROVES QUALITY OF LIFE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Tatsumi, K., Fukuchi, Y., & for the PEACE Study Group (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01373.x · Cited by 45 · see citing works

Effect of carbocisteine on patients with COPD: a systematic review and meta-analysis

Zeng, Z., Yang, D., Huang, X., & Xiao, Z. (2017) · International Journal of COPD · doi:10.2147/copd.s140603 · Cited by 42 · see citing works

Decreased glutathione and low catalase activity contribute to oxidative stress in children with α-1 antitrypsin deficiency: Table 1

Escribano, A., Amor, M., Pastor, S., Castillo, S., Sanz, F., Codoñer‐Franch, P., & Dası́, F. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-205898 · Cited by 39 · see citing works

Impaired efferocytosis in human chronic granulomatous disease is reversed by pioglitazone treatment

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Effect of fudosteine on mucin production

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N‐isobutyrylcysteine, a donor of systemic thiols, does not reduce the exacerbation rate in chronic bronchitis

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