Joint Estimates of Quantitative Trait Locus Effect and Frequency Using Synthetic Recombinant Populations of Drosophila melanogaster

Macdonald, Stuart J; Long, Anthony D

doi:10.1534/genetics.106.069641

Cited by 61Genetic Mapping and Diversity in Plants and AnimalsGenetic and phenotypic traits in livestockGenetic Associations and Epidemiology

Joint Estimates of Quantitative Trait Locus Effect and Frequency Using Synthetic Recombinant Populations of Drosophila melanogaster

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Macdonald, Stuart J, Long, Anthony D·2007·Genetics

DOI 10.1534/genetics.106.069641PMC PMC1894589

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Abstract

We develop and implement a strategy to map QTL in two synthetic populations of Drosophila melanogaster each initiated with eight inbred founder strains. These recombinant populations allow simultaneous estimates of QTL location, effect, and frequency. Five X-linked QTL influencing bristle number were resolved to intervals of ∼1.3 cM. We confirm previous observations of bristle number QTL distal to 4A at the tip of the chromosome and identify two novel QTL in 7F–8C, an interval that does not include any classic bristle number candidate genes. If QTL at the tip of the X are biallelic they appear to be intermediate in frequency, although there is evidence that these QTL may reside in multiallelic haplotypes. Conversely, the two QTL mapping to the middle of the X chromosome are likely rare: in each case the minor allele is observed in only 1 of the 16 founders. Assuming additivity and biallelism we estimate that identified QTL contribute 1.0 and 8.7%, respectively, to total phenotypic variation in male abdominal and sternopleural bristle number in nature. Models that seek to explain the maintenance of genetic variation make different predictions about the population frequency of QTL alleles. Thus, mapping QTL in eight-way recombinant populations can distinguish between these models.

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Transgressive segregation in mapping populations of mice and flies from eight founder strains provides strong empirical support for common polygenes.
“the phenomenon of transgressive segregation in mapping populations of mice and flies established from eight founder strains provides strong empirical support for the existence of common polygenes94–96.”
From Rare and common variants: twenty arguments (2012) · cites this paper as [96]

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Authors: Macdonald, S. J., & Long, A. D.
Affiliations: University of Kansas (US)
University of California, Irvine (US)
Corresponding author: Macdonald, Stuart J
ORCID: Macdonald, Stuart J
Long, Anthony D
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 2007-06-01
Volume: 176
Issue: 2
Pages: 1261-1281
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1534/genetics.106.069641
PMC: PMC1894589
OpenAlex: W2099625405
Cited by: 61
References: 93
Citations by year: 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 14
FWCI: 2.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (0614429)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: quantitative trait loci, QTL mapping, Drosophila melanogaster, bristle number, X chromosome, QTL effect size, maintenance of genetic variation, sternopleural bristles
MeSH terms: Animals, Chromosome Mapping, Crosses, Genetic, Drosophila melanogaster, Female, Gene Frequency, Genetic Carrier Screening, Male, Molecular Sequence Data, Recombination, Genetic, Genome, Founder Effect, Quantitative Trait Loci

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Joint Estimates of Quantitative Trait Locus Effect and Frequency Using Synthetic Recombinant Populations of Drosophila melanogaster

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