The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes
Open accessAbstract
Phenotypic stereotypes are traits, often polygenic, that have been stringently selected to conform to specific criteria. In dogs, Canis familiaris, stereotypes result from breed standards set for conformation, performance (behaviors), etc. As a consequence, phenotypic values measured on a few individuals are representative of the breed stereotype. We used DNA samples isolated from 148 dog breeds to associate SNP markers with breed stereotypes. Using size as a trait to test the method, we identified six significant quantitative trait loci (QTL) on five chromosomes that include candidate genes appropriate to regulation of size (e.g., IGF1, IGF2BP2 SMAD2, etc.). Analysis of other morphological stereotypes, also under extreme selection, identified many additional significant loci. Less well-documented data for behavioral stereotypes tentatively identified loci for herding, pointing, boldness, and trainability. Four significant loci were identified for longevity, a breed characteristic not under direct selection, but inversely correlated with breed size. The strengths and limitations of the approach are discussed as well as its potential to identify loci regulating the within-breed incidence of specific polygenic diseases.
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Cites
Genome sequence, comparative analysis and haplotype structure of the domestic dog
members, B. S. P., Lindblad-Toh, K., Wade, C. M., Mikkelsen, T. S., Karlsson, E. K., Jaffe, D. B., Kamal, M., Clamp, M., Chang, J. L., Kulbokas, E. J., et al. (2005) · Nature · doi:10.1038/nature04338 · Cited by 2,568
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Cited by
A Simple Genetic Architecture Underlies Morphological Variation in Dogs
Boyko, A. R., Quignon, P., Li, L., Schoenebeck, J. J., Degenhardt, J. D., Lohmueller, K. E., Zhao, K., Brisbin, A., Parker, H. G., vonHoldt, B. M., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000451 · Cited by 494
Self-citationvonHoldt, B. M., Shuldiner, E., Koch, I. J., Kartzinel, R. Y., Hogan, A., Brubaker, L., Wanser, S., Stahler, D., Wynne, C. D. L., Ostrander, E. A., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700398 · Cited by 186
Boyko, A. R., Boyko, R. H., Boyko, C. M., Parker, H. G., Castelhano, M., Corey, L., Degenhardt, J. D., Auton, A., Hedimbi, M., Kityo, R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902129106 · Cited by 182
Self-citationGenetic mapping of canine fear and aggression
Zapata, I., Serpell, J. A., & Alvarez, C. E. (2016) · BMC Genomics · doi:10.1186/s12864-016-2936-3 · Cited by 168
Highly heritable and functionally relevant breed differences in dog behaviour
MacLean, E. L., Snyder-Mackler, N., vonHoldt, B. M., & Serpell, J. A. (2019) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2019.0716 · Cited by 144
Metadata
- Authors
- Jones, P., Chase, K., Martin, A., Davern, P., Ostrander, E. A., & Lark, K. G.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-06-01
- Volume
- 179
- Issue
- 2
- Pages
- 1033-1044
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2140850653
- Cited by
- 161
- References
- 1
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Jones, P., Chase, K., Martin, A., Davern, P., Ostrander, E. A., & Lark, K. G. (2008). Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes. Genetics. https://doi.org/10.1534/genetics.108.087866
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