Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs
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, genes previously implicated in the behavioral phenotype of patients with WBS and contained within the WBS locus, contribute to extreme sociability in dogs. This finding suggests that there are commonalities in the genetic architecture of WBS and canine tameness and that directional selection may have targeted a unique set of linked behavioral genes of large phenotypic effect, allowing for rapid behavioral divergence of dogs and wolves, facilitating coexistence with humans.
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Among the genes under selection in both AMH and one or more domesticates, as well as in those under selection in multiple domesticates though not AMH, one finds multiple strong candidates for neurodevelopmental diseases and syndromes.
“In a similar vein, among the genes under selection in both AMH and one or more domesticates, as well as in those under selection in multiple domesticates though not AMH, one finds multiple strong candidates for neurodevelopmental diseases and syndromes (see also [128]).”
From Self-domestication in Homo sapiens: Insights from comparative genomics (2017) · cites this paper as [128]
Structural variants in WBS genes, for example in GTF2I and its paralogs, underlie stereotypical hypersociability in domestic dogs and foxes.
“Structural variants in WBS genes, for example in the case of GTF2I and its paralogs, have been shown to underlie stereotypical hypersociability in domestic dogs and foxes (8, 9).”
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“Later, it was suggested that these changes also extend to conspecifics and that a similar process occurred during human evolution (HSD Hypothesis [4,47]).”
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BackgroundResultInfluentialSelf-citationDid Dog Domestication Contribute to Language Evolution?
Benítez‐Burraco, A., Pörtl, D., & Jung, C. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.695116 · Cited by 5 · see citing works
- Authors
- vonHoldt, B. M., Shuldiner, E., Koch, I. J., Kartzinel, R. Y., Hogan, A., Brubaker, L., Wanser, S., Stahler, D., Wynne, C. D. L., Ostrander, E. A., Sinsheimer, J. S., & Udell, M. A. R.
- Affiliations
- Princeton University (US)
- National Institutes of Health (US)
- Oregon State University (US)
- National Park Service (US)
- Arizona State University (US)
- University of California, Los Angeles (US)
- Corresponding author
- vonHoldt, Bridgett M.
- ORCID
- Venue
- Science Advances
- Published
- 2017-07-07
- Volume
- 3
- Issue
- 7
- Pages
- e1700398-e1700398
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC5517105
- OpenAlex
- W2739139079
- Cited by
- 186
- References
- 97
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 17 · 2023: 15 · 2022: 28 · 2021: 27 · 2020: 21 · 2019: 18 · 2018: 27 · 2017: 4
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Science Advances (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Arizona State University Library Digital Repository (Arizona State University) (submittedVersion, cc-by-nc-nd)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (award321887, GM086887)
- National Science Foundation (award321886, DEB-1245373, award321888, DMS 1264153)
- Princeton University (award321885, EEB, Dean of the College, Council on Science and Technology)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- Williams syndrome, structural variants, dogs, hypersociability, sociability, directional selection, human-dog coexistence, comparative genomics
- MeSH terms
- Animals, Behavior, Animal, Dog Diseases, Dogs, Humans, Social Behavior, Stereotyped Behavior, Genetic Variation, Reproducibility of Results, Polymerase Chain Reaction, Williams Syndrome, Computational Biology, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genetic Association Studies, Molecular Sequence Annotation
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