Genetic mapping of canine fear and aggression
Open accessAbstract
BACKGROUND: Fear/anxiety and anger/aggression greatly influence health, quality of life and social interactions. They are a huge burden to wellbeing, and personal and public economics. However, while much is known about the physiology and neuroanatomy of such emotions, little is known about their genetics - most importantly, why some individuals are more susceptible to pathology under stress. RESULTS: We conducted genomewide association (GWA) mapping of breed stereotypes for many fear and aggression traits across several hundred dogs from diverse breeds. We confirmed those findings using GWA in a second cohort of partially overlapping breeds. Lastly, we used the validated loci to create a model that effectively predicted fear and aggression stereotypes in a third group of dog breeds that were not involved in the mapping studies. We found that i) known IGF1 and HMGA2 loci variants for small body size are associated with separation anxiety, touch-sensitivity, owner directed aggression and dog rivalry; and ii) two loci, between GNAT3 and CD36 on chr18, and near IGSF1 on chrX, are associated with several traits, including touch-sensitivity, non-social fear, and fear and aggression that are directed toward unfamiliar dogs and humans. All four genome loci are among the most highly evolutionarily-selected in dogs, and each of those was previously shown to be associated with morphological traits. We propose that the IGF1 and HMGA2 loci are candidates for identical variation being associated with both behavior and morphology. In contrast, we show that the GNAT3-CD36 locus has distinct variants for behavior and morphology. The chrX region is a special case due to its extensive linkage disequilibrium (LD). Our evidence strongly suggests that sociability (which we propose is associated with HS6ST2) and fear/aggression are two distinct GWA loci within this LD block on chrX, but there is almost perfect LD between the peaks for fear/aggression and animal size. CONCLUSIONS: We have mapped many canine fear and aggression traits to single haplotypes at the GNAT3-CD36 and IGSF1 loci. CD36 is widely expressed, but areas of the amygdala and hypothalamus are among the brain regions with highest enrichment; and CD36-knockout mice are known to have significantly increased anxiety and aggression. Both of the other genes have very high tissue-specificity and are very abundantly expressed in brain regions that comprise the core anatomy of fear and aggression - the amygdala to hypothalamic-pituitary-adrenal (HPA) axis. We propose that reduced-fear variants at these loci may have been involved in the domestication process.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aggression and fear are associated with the same genetic loci linked to small body size.
“Aggression and fear are associated with the same genetic loci linked to small body size, as suggested by the correlation found in Zapata et al.’s studies [162,163].”
From Ethical Concerns about Fashionable Dog Breeding (2024) · cites this paper as [162]
The Discussion links owner-directed aggression and some fear-related traits to IGF1 variation associated with small body size. But it distinguishes these from dog- and stranger-oriented fear and aggression, which are more strongly associated with loci on chromosomes 18 and X. The claim is therefore too broad if read as applying to fear and aggression generally. (LLM, conf=0.85)
Experimental — accuracy not yet measuredNon-genetic models, such as stress-induced aggression and other organisms, were not included in this study.
“We noted that non-genetic models, such as stress-induced aggression [27, 81] and other organisms [30, 31, 82], were not included in this study.”
From An integrated analysis of genes and functional pathways for aggression in human and rodent models (2019) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286 · see citing works
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J., Fry, B., Maller, J., & Daly, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bth457 · Cited by 15,086 · see citing works
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400 · see citing works
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572 · see citing works
Genome-wide efficient mixed-model analysis for association studies
Zhou, X., & Stephens, M. (2012) · Nature Genetics · doi:10.1038/ng.2310 · Cited by 3,627 · see citing works
The hitch-hiking effect of a favourable gene
Smith, J. M., & Haigh, J. (1974) · Genetical Research · doi:10.1017/s0016672300014634 · Cited by 3,415 · see citing works
The hitch-hiking effect of a favourable gene
MAYNARD, J., & Haigh, J. (2007) · Genetics Research · doi:10.1017/s0016672308009579 · Cited by 2,663 · see citing works
Genome-wide detection and characterization of positive selection in human populations
The International HapMap Consortium, Sabeti, P. C., Varilly, P., Fry, B., Lohmueller, J., Hostetter, E., Cotsapas, C., Xie, X., Byrne, E. H., McCarroll, S. A., et al. (2007) · Nature · doi:10.1038/nature06250 · Cited by 2,131 · see citing works
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Thorgeirsson, T. E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K. P., Manolescu, A., Thorleifsson, G., Stefansson, H., Ingason, A., et al. (2008) · Nature · doi:10.1038/nature06846 · Cited by 1,523 · see citing works
The “hitchhiking effect” revisited
Kaplan, N. L., Hudson, R. R., & Langley, C. H. (1989) · Genetics · doi:10.1093/genetics/123.4.887 · Cited by 1,076 · see citing works
The genomic signature of dog domestication reveals adaptation to a starch-rich diet
Axelsson, E., Ratnakumar, A., Arendt, M.-L., Maqbool, K., Webster, M. T., Perloski, M., Liberg, O., Arnemo, J. M., Hedhammar, Å., & Lindblad-Toh, K. (2013) · Nature · doi:10.1038/nature11837 · Cited by 963 · see citing works
A de novo paradigm for mental retardation.
Vissers, L. E. L. M., de Ligt, J., Gilissen, C., Janssen, I., Steehouwer, M., de Vries, P., van Lier, B., Arts, P., Wieskamp, N., del Rosario, M., et al. (2010) · Nature Genetics · doi:10.1038/ng.712 · Cited by 852 · see citing works
The Domestic dog: its evolution, behaviour, and interactions with people
Williams (1996) · Choice Reviews Online · doi:10.5860/choice.33-5715 · Cited by 738 · see citing works
Hsu, Y., & Serpell, J. A. (2003) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.2003.223.1293 · Cited by 709 · see citing works
Self-citationA framework for studying emotions across species
Anderson, D. J., & Adolphs, R. (2014) · Cell · doi:10.1016/j.cell.2014.03.003 · Cited by 691 · see citing works
Efficient mapping of mendelian traits in dogs through genome-wide association
Karlsson, E. K., Baranowska, I., Wade, C. M., Hillbertz, N. S., Zody, M. C., Anderson, N., Biagi, T., Patterson, N. J., Pielberg, G., Kulbokas, E. J., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.10 · Cited by 560 · see citing works
A Simple Genetic Architecture Underlies Morphological Variation in Dogs
Boyko, A., Quignon, P., Li, L., Schoenebeck, J., Degenhardt, J. D., Lohmueller, K., Zhao, K., Brisbin, A., Parker, H., Vonholdt, B., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000451 · Cited by 469 · see citing works
A genome-wide association study of alcohol dependence
Bierut, L. J., Agrawal, A., Bucholz, K. K., Doheny, K. F., Laurie, C., Pugh, E., Fisher, S., Fox, L., Howells, W., Bertelsen, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911109107 · Cited by 457 · see citing works
Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Pielberg, G., Sigurðsson, S., Fall, T., Seppälä, E. H., Hansen, M. S., Lawley, C., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002316 · Cited by 390 · see citing works
BioGPS and MyGene.info: organizing online, gene-centric information
Wu, C., MacLeod, I., & Su, A. I. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1114 · Cited by 355 · see citing works
Stephan, W., Wiehe, T., & Lenz, M. W. (1992) · Theoretical Population Biology · doi:10.1016/0040-5809(92)90045-u · Cited by 351 · see citing works
Tracking footprints of artificial selection in the dog genome
Akey, J. M., Ruhe, A. L., Akey, D. T., Wong, A. K., Connelly, C. F., Madeoy, J., Nicholas, T. J., & Neff, M. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909918107 · Cited by 350 · see citing works
Out of southern East Asia: the natural history of domestic dogs across the world
Wang, G., Zhai, W., Yang, H., Wang, L., Li, Z., Yan-hu, L., Fan, R., Yin, T., Zhu, C., Poyarkov, A. D., et al. (2015) · Cell Research · doi:10.1038/cr.2015.147 · Cited by 350 · see citing works
Frantz, L., Schraiber, J. G., Madsen, O., Megens, H., Cagan, A., Bosse, M., Paudel, Y., Crooijmans, R. P. M. A., Larson, G., & Groenen, M. A. M. (2015) · Nature Genetics · doi:10.1038/ng.3394 · Cited by 342 · see citing works
Parker, H. G., VonHoldt, B. M., Quignon, P., Margulies, E. H., Shao, S., Mosher, D. S., Spady, T. C., Elkahloun, A., Cargill, M., Jones, P. G., et al. (2009) · Science · doi:10.1126/science.1173275 · Cited by 342 · see citing works
Dog bites to humans—demography, epidemiology, injury, and risk
Overall, K. L., & Love, M. (2001) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.2001.218.1923 · Cited by 336 · see citing works
Breed differences in canine aggression
Duffy, D. L., Hsu, Y., & Serpell, J. A. (2008) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2008.04.006 · Cited by 334 · see citing works
Self-citationCovert expectation-of-reward in rat ventral striatum at decision points
van der Meer, M. A. A. (2009) · Frontiers in Integrative Neuroscience · doi:10.3389/neuro.07.001.2009 · Cited by 296 · see citing works
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Cornelis, M. C., Byrne, E. M., Esko, T., Nalls, M. A., Ganna, A., Paynter, N. P., Monda, K. L., Amin, N., Fischer, K., Renström, F., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.107 · Cited by 287 · see citing works
Chen, C., Rainnie, D. G., Greene, R. W., & Tonegawa, S. (1994) · Science · doi:10.1126/science.7939668 · Cited by 286 · see citing works
An Improved Canine Genome and a Comprehensive Catalogue of Coding Genes and Non-Coding Transcripts
Hoeppner, M. P., Lundquist, A. L., Pirun, M., Meadows, J. R. S., Zamani, N., Johnson, J., Sundström, G., Cook, A., FitzGerald, M. G., Swofford, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091172 · Cited by 273 · see citing works
Sweet taste signaling functions as a hypothalamic glucose sensor
Ren, X. (2009) · Frontiers in Integrative Neuroscience · doi:10.3389/neuro.07.012.2009 · Cited by 267 · see citing works
Predictive validity of a method for evaluating temperament in young guide and service dogs
Duffy, D. L., & Serpell, J. A. (2012) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2012.02.011 · Cited by 220 · see citing works
Self-citationSun, Y., Bak, B., Schoenmakers, N., van Trotsenburg, A. S. P., Oostdijk, W., Voshol, P., Cambridge, E., White, J. K., le Tissier, P., Gharavy, S. N. M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2453 · Cited by 217 · see citing works
Dog Behavior Co-Varies with Height, Bodyweight and Skull Shape
McGreevy, P. D., Georgevsky, D., Carrasco, J., Valenzuela, M., Duffy, D. L., & Serpell, J. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080529 · Cited by 213 · see citing works
Self-citationGenetics of human aggressive behaviour
Craig, I. W., & Halton, K. E. (2009) · Human Genetics · doi:10.1007/s00439-009-0695-9 · Cited by 213 · see citing works
The role of genetic variation in the causation of mental illness: an evolution-informed framework
Uher, R. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.85 · Cited by 189 · see citing works
Derived variants at six genes explain nearly half of size reduction in dog breedsPreprint
Rimbault, M., Beale, H. C., Schoenebeck, J. J., Hoopes, B. C., Allen, J. J., Kilroy-Glynn, P., Wayne, R. K., Sutter, N. B., & Ostrander, E. A. (2013) · Genome Research · doi:10.1101/gr.157339.113 · Cited by 171 · see citing works
Effects of breed, sex, and neuter status on trainability in dogs
Serpell, J. A., & Hsu, Y. (2005) · Anthrozoös · doi:10.2752/089279305785594135 · Cited by 167 · see citing works
Self-citationSingle-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes
Jones, P., Chase, K., Martin, A. J., Davern, P., Ostrander, E., & Lark, K. G. (2008) · Genetics · doi:10.1534/genetics.108.087866 · Cited by 159 · see citing works
Mapping DNA structural variation in dogsPreprint
Chen, W., Swartz, J. D., Rush, L. J., & Alvarez, C. E. (2008) · Genome Research · doi:10.1101/gr.083741.108 · Cited by 128 · see citing works
Self-citationSerpell, J. A., & Duffy, D. L. (2014) · Springer eBooks · doi:10.1007/978-3-642-53994-7_2 · Cited by 118 · see citing works
Self-citationTang, R., Noh, H. J., Wang, D., Sigurðsson, S., Swofford, R., Perloski, M., Duxbury, M. M., Patterson, E. E., Albright, J., Castelhano, M. G., et al. (2014) · Genome biology · doi:10.1186/gb-2014-15-3-r25 · Cited by 104 · see citing works
Molecular genetics and subjective well-being
Rietveld, C. A., Cesarini, D., Benjamin, D. J., Koellinger, P. D., De Neve, J.-E., Tiemeier, H., Johannesson, M., Magnusson, P. K. E., Pedersen, N. L., Krueger, R. F., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222171110 · Cited by 104 · see citing works
Use of fluoxetine to treat dominance aggression in dogs
Dodman, N. H., Donnelly, R., Shuster, L., Mertens, P. A., Rand, W., & Miczek, K. A. (1996) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1996.209.09.1585 · Cited by 96 · see citing works
Lord, K. A., Schneider, R. A., & Coppinger, R. (2016) · Cambridge University Press eBooks · doi:10.1017/9781139161800.004 · Cited by 96 · see citing works
DoGSD: the dog and wolf genome SNP database
Bai, B., Zhao, W., Tang, B., Wang, Y.-Q., Wang, L., Zhang, Z., Yang, H., Yan-hu, L., Zhu, J., Irwin, D. M., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1174 · Cited by 90 · see citing works
Gelernter, J. E., Page, G. P., Stein, M. B., & Woods, S. W. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.59 · Cited by 86 · see citing works
Foyer, P., Bjällerhag, N., Wilsson, E., & Jensen, P. (2014) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2014.03.006 · Cited by 86 · see citing works
Novel origins of copy number variation in the dog genome
Berglund, J., Nevalainen, E., Molin, A.-M., Perloski, M., André, C., Zody, M. C., Sharpe, T., Hitte, C., Lindblad‐Toh, K., Lohi, H., et al. (2012) · Genome biology · doi:10.1186/gb-2012-13-8-r73 · Cited by 78 · see citing works
Ruíz-Ávila, L., Wong, G. T., Damak, S., & Margolskee, R. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151235798 · Cited by 77 · see citing works
Environmental Effects on Compulsive Tail Chasing in Dogs
Tiira, K., Hakosalo, O., Kareinen, L., Thomas, A., Hielm-Björkman, A. K., Escriou, C., Arnold, P. D., & Lohi, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041684 · Cited by 77 · see citing works
Nicholas, T. J., Baker, C. A., Eichler, E. E., & Akey, J. M. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-414 · Cited by 75 · see citing works
Naturally Occurring Cancers in Dogs: Insights for Translational Genetics and Medicine
Alvarez, C. E. (2014) · ILAR Journal · doi:10.1093/ilar/ilu010 · Cited by 72 · see citing works
Self-citationDehkordi, O., Rose, J. E., Fatemi, M., Allard, J. S., Balan, K. V., Young, J. K., Fatima, S., Millis, R. M., & Jayam‐Trouth, A. (2012) · Brain Research · doi:10.1016/j.brainres.2012.07.038 · Cited by 68 · see citing works
Evaluation of a behavioral assessment tool for dogs relinquished to shelters
Duffy, D. L., Kruger, K. A., & Serpell, J. A. (2014) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2014.10.003 · Cited by 67 · see citing works
Self-citationValidity of model devices used to assess canine temperament in behavioral tests
Barnard, S., Siracusa, C., Reisner, I. R., Valsecchi, P., & Serpell, J. A. (2012) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2012.02.017 · Cited by 62 · see citing works
Self-citationIsoflurane Modulates Genomic Expression in Rat Amygdala
Rampil, I. J., Moller, D. H., & Bell, A. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000202384.96269.51 · Cited by 49 · see citing works
Breed-dependent differences in the onset of fear-related avoidance behavior in puppies
Morrow, M., Ottobre, J. S., OTTOBRE, A. C., Neville, P. F., St-Pierre, N. R., Dreschel, N. A., & Pate, J. L. (2015) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2015.03.002 · Cited by 47 · see citing works
α‐Gustducin expression in the vomeronasal organ of the mouse
Zancanaro, C., Mucignat‐Caretta, C., Merigo, F., Cavaggioni, A., & Osculati, F. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00912.x · Cited by 44 · see citing works
Tizzano, M., Merigo, F., & Sbarbati, A. (2006) · Journal of Anatomy · doi:10.1111/j.1469-7580.2006.00617.x · Cited by 44 · see citing works
Rare coding variants and X-linked loci associated with age at menarche
Lunetta, K. L., Day, F. R., Sulem, P., Ruth, K. S., Tung, J. Y., Hinds, D. A., Esko, T., Elks, C. E., Altmaier, E., He, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms8756 · Cited by 42 · see citing works
Meester, R. H. D., Bacquer, D. D., Peremans, K. Y., Vermeire, S. T., Planta, D. J. U., Coopman, F., & Audenaert, K. (2008) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2007.10.005 · Cited by 42 · see citing works
Genetics of behavior in the silver fox
Kukekova, A. V., Temnykh, S. V., Johnson, J. L., Trut, L. N., & Acland, G. M. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9373-z · Cited by 40 · see citing works
Shin, Y., Park, J.-H., Choi, J., Chun, M., Moon, Y. W., & Lee, M. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0223-2 · Cited by 39 · see citing works
Expression of CD36 by Olfactory Receptor Cells and Its Abundance on the Epithelial Surface in Mice
Lee, S., Eguchi, A., Tsuzuki, S., Matsumura, S., Inoue, K., Iwanaga, T., Masuda, D., Yamashita, S., & Fushiki, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133412 · Cited by 33 · see citing works
Involvement of brain serotonin 5-HT1A receptors in genetic predisposition to aggressive behavior
Popova, N. K., Naumenko, V. S., & Plyusnina, I. Z. (2007) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-007-0062-z · Cited by 33 · see citing works
Spatial and temporal expression of immunoglobulin superfamily member 1 in the rat
Joustra, S. D., Meijer, O. C., Heinen, C. A., Mol, I. M., Laghmani, E. H., Sengers, R. M. A., Carreno, G., van Trotsenburg, A. S. P., Biermasz, N. R., Bernard, D. J., et al. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0204 · Cited by 32 · see citing works
An anxiety-like phenotype in mice selectively bred for aggression
Nehrenberg, D. L., Rodriguiz, R. M., Cyr, M., Zhang, X., Lauder, J. M., Gariépy, J., & Wetsel, W. C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.02.010 · Cited by 29 · see citing works
Grimm, D. (2015) · Science · doi:10.1126/science.348.6232.274 · Cited by 27 · see citing works
Enkephalin knockdown in the central amygdala nucleus reduces unconditioned fear and anxiety
Poulin, J., Bérubé, P., Laforest, S., & Drolet, G. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12134 · Cited by 24 · see citing works
Zucchi, F. C. R., Yao, Y., Ilnytskyy, Y., Robbins, J. C., Soltanpour, N., Kovalchuk, I., Kovalchuk, O., & Metz, G. A. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092130 · Cited by 20 · see citing works
Dodman, N. H., Moon, R., & Zelin, M. L. (1996) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1996.209.06.1107 · Cited by 19 · see citing works
Behavioral characterization of CD36 knockout mice with SHIRPA primary screen
Zhang, S., Wang, W., Li, J., Cheng, K., Zhou, J., Zhu, D., Yang, D., Liang, Z., Fang, L., Liao, L., et al. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.11.027 · Cited by 18 · see citing works
Analysis of Expression Data: An Overview
Grewal, A., Lambert, P., & Stockton, J. (2007) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg1104s54 · Cited by 16 · see citing works
Characterization and Treatment of 20 Canine Dominance Aggression Cases.
Uchida, Y., Dodman, N. H., DeNAPOLI, J., & Aronson, L. (1997) · Journal of Veterinary Medical Science · doi:10.1292/jvms.59.397 · Cited by 10 · see citing works
Analysis of Expression Data: An Overview
Grewal, A., Lambert, P., & Stockton, J. (2007) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi0701s17 · Cited by 10 · see citing works
Ha, J. H., Alam, M. S., Lee, D. H., & Kim, J.-J. (2015) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.14.0941 · Cited by 6 · see citing works
Analysis of Expression Data: An Overview
Grewal, A., Lambert, P., & Stockton, J. (2003) · Current Protocols in Human Genetics · doi:10.1002/0471142905.hg1104s38 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Jagannathan, V., Drögemüller, C., & Leeb, T. (2019) · Animal Genetics · doi:10.1111/age.12834 · Cited by 191 · see citing works
Demographic history, selection and functional diversity of the canine genome
Ostrander, E. A., Wayne, R. K., Freedman, A. H., & Davis, B. W. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.67 · Cited by 183 · see citing works
Prevalence, comorbidity, and breed differences in canine anxiety in 13,700 Finnish pet dogs
Salonen, M., Sulkama, S., Mikkola, S., Puurunen, J., Hakanen, E., Tiira, K., Araujo, C., & Lohi, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-59837-z · Cited by 182 · see citing works
Highly heritable and functionally relevant breed differences in dog behaviour
MacLean, E. L., Snyder-Mackler, N., vonHoldt, B. M., & Serpell, J. A. (2019) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2019.0716 · Cited by 144 · see citing works
Self-citationMeđugorac, I., Graf, A., Grohs, C., Rothammer, S., Zagdsuren, Y., Александровна, Г. Е., Zinovieva, N. A., Barbieri, J., Seichter, D., Ruß, I., et al. (2017) · Nature Genetics · doi:10.1038/ng.3775 · Cited by 129 · see citing works
Genetic Characterization of Dog Personality Traits
Ilska, J. J., Haskell, M. J., Blott, S. C., Sánchez-Molano, E., Polgár, Z., Lofgren, S. E., Clements, D. N., & Wiener, P. (2017) · Genetics · doi:10.1534/genetics.116.192674 · Cited by 100 · see citing works
An integrated analysis of genes and functional pathways for aggression in human and rodent models
Zhang-James, Y., Fernàndez-Castillo, N., Hess, J. L., Malki, K., Glatt, S. J., Cormand, B., & Faraone, S. V. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0068-7 · Cited by 98 · see citing works
Puurunen, J., Hakanen, E., Salonen, M. K., Mikkola, S., Sulkama, S., Araujo, C., & Lohi, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-60546-w · Cited by 96 · see citing works
Domestic dog lineages reveal genetic drivers of behavioral diversification
Dutrow, E. V., Serpell, J. A., & Ostrander, E. A. (2022) · Cell · doi:10.1016/j.cell.2022.11.003 · Cited by 94 · see citing works
Self-citationMcPeake, K. J., Collins, L., Zulch, H. E., & Mills, D. S. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00152 · Cited by 72 · see citing works
Impulsivity and behaviour problems in dogs: A Reinforcement Sensitivity Theory perspective
Piotti, P., Satchell, L. P., & Lockhart, T. (2018) · Behavioural Processes · doi:10.1016/j.beproc.2018.03.012 · Cited by 66 · see citing works
RBFOX1, encoding a splicing regulator, is a candidate gene for aggressive behavior
Noèlia Fernàndez-castillo, A., Gan, G., van Donkelaar, M. M. J., Vaht, M., Weber, H., Retz, W., Meyer‐Lindenberg, A., Franke, B., Harro, J., Reif, A., et al. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.11.012 · Cited by 64 · see citing works
Fearful Fido: Investigating dog experience in the veterinary context in an effort to reduce distress
Edwards, P. T., Smith, B. P., McArthur, M. L., & Hazel, S. J. (2019) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2019.02.009 · Cited by 64 · see citing works
Behavioural correlations of the domestication syndrome are decoupled in modern dog breeds
Wheat, C. H., Fitzpatrick, J. L., Rogell, B., & Temrin, H. (2019) · Nature Communications · doi:10.1038/s41467-019-10426-3 · Cited by 61 · see citing works
Wallis, L., Szabó, D., & Enikö Kubinyi, B. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00493 · Cited by 58 · see citing works
Two novel genomic regions associated with fearfulness in dogs overlap human neuropsychiatric loci
Sarviaho, R., Hakosalo, O., Tiira, K., Sulkama, S., Salmela, E., Hytönen, M. K., Sillanpää, M. J., & Lohi, H. (2019) · Translational Psychiatry · doi:10.1038/s41398-018-0361-x · Cited by 48 · see citing works
Shan, S., Xu, F., & Brenig, B. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.693290 · Cited by 45 · see citing works
Genetics and Brain Transcriptomics of Completed Suicide
Punzi, G., Ursini, G., Chen, Q., Radulescu, E., Tao, R., Huuki-Myers, L. A., Carlo, P. D., Collado‐Torres, L., Shin, J. H., Catanesi, R., et al. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2021.21030299 · Cited by 45 · see citing works
Active and social life is associated with lower non-social fearfulness in pet dogs
Hakanen, E., Mikkola, S., Salonen, M., Puurunen, J., Sulkama, S., Araujo, C., & Lohi, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-70722-7 · Cited by 44 · see citing works
Hecht, E. E., Zapata, I., Alvarez, C. E., Gutman, D. A., Preuss, T. M., Kent, M., & Serpell, J. A. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02368-8 · Cited by 45 · see citing works
Self-citationGenetic testing of dogs predicts problem behaviors in clinical and nonclinical samples
Zapata, I., Lilly, M. L., Herron, M. E., Serpell, J. A., & Alvarez, C. E. (2022) · BMC Genomics · doi:10.1186/s12864-022-08351-9 · Cited by 40 · see citing works
Self-citationBreed Differences in Dog Cognition Associated with Brain-Expressed Genes and Neurological Functions
Gnanadesikan, G. E., Hare, B. A., Snyder‐Mackler, N., Call, J., Kaminski, J., Miklósi, Á., & MacLean, E. L. (2020) · Integrative and Comparative Biology · doi:10.1093/icb/icaa112 · Cited by 40 · see citing works
Behavior Differences Between Search-and-Rescue and Pet Dogs
Hare, E., Kelsey, K. M., Serpell, J. A., & Otto, C. M. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00118 · Cited by 33 · see citing works
Self-citationElephants as an animal model for self-domestication
Raviv, L., Jacobson, S. L., Plotnik, J. M., Bowman, J. D., Lynch, V. J., & Benítez‐Burraco, A. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208607120 · Cited by 33 · see citing works
Genetic dissection of complex behaviour traits in German Shepherd dogs
Friedrich, J., Strandberg, E., Arvelius, P., Sánchez-Molano, E., Pong‐Wong, R., Hickey, J. M., Haskell, M. J., & Wiener, P. (2019) · Heredity · doi:10.1038/s41437-019-0275-2 · Cited by 30 · see citing works
Dobos, P., & Pongrácz, P. (2023) · Animals · doi:10.3390/ani13122001 · Cited by 30 · see citing works
The behavioral genetics of nonhuman primates: Status and prospects
Rogers, J. (2018) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23384 · Cited by 27 · see citing works
Zapata, I., Moraes, L. E., Fiala, E. M., Zaldívar‐López, S., Couto, C. G., Rowell, J., & Alvarez, C. E. (2019) · BMC Genomics · doi:10.1186/s12864-019-5531-6 · Cited by 27 · see citing works
Self-citationDNA methylation in canine brains is related to domestication and dog-breed formation
Sundman, A.-S., Pértille, F., Coutinho, L. L., JAZIN, E. E., Guerrero‐Bosagna, C., & Jensen, P. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240787 · Cited by 25 · see citing works
Витальевна, Ч. И., Ponomarenko, M. P., Рассказов, Д. А., Sharypova, E. B., Kashina, E. V., Matveeva, M. Y., Arshinova, T. V., Ponomarenko, P. M., Arkova, O. V., Bondar, N. P., et al. (2016) · BMC Genomics · doi:10.1186/s12864-016-3353-3 · Cited by 24 · see citing works
Lee, M. O., Li, J., Davis, B. W., Upadhyay, S., Muhisen, H. M. A., Suva, L. J., Clement, T. M., & Andersson, L. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab417 · Cited by 23 · see citing works
Friedrich, J., Talenti, A., Arvelius, P., Strandberg, E., Haskell, M. J., & Wiener, P. (2020) · Advanced Genetics · doi:10.1002/ggn2.10024 · Cited by 21 · see citing works
Latent class analysis of behavior across dog breeds reveal underlying temperament profiles
Zapata, I., Eyre, A. W., Alvarez, C. E., & Serpell, J. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-20053-6 · Cited by 22 · see citing works
Self-citationRisk factors of separation-related behaviours in Australian retrievers
van Rooy, D., Thomson, P. C., McGreevy, P. D., & Wade, C. M. (2018) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2018.09.001 · Cited by 21 · see citing works
Expression of Behavioural Traits in Goldendoodles and Labradoodles
Shouldice, V. L., Edwards, A. M., Serpell, J. A., Niel, L., & Robinson, J. A. B. (2019) · Animals · doi:10.3390/ani9121162 · Cited by 22 · see citing works
Self-citationHammond, A., Rowland, T., Mills, D. S., & Pilot, M. (2022) · Evolutionary Applications · doi:10.1111/eva.13479 · Cited by 21 · see citing works
The influence of X chromosome variants on trait neuroticism
Michelle Luciano, A., Davies, G., SUMMERS, K. M., Hill, W. D., Hayward, C., Liewald, D. C. M., Porteous, D. J., Galé, C. R., McIntosh, A. M., & Deary, I. J. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0388-2 · Cited by 21 · see citing works
A novel genomic region on chromosome 11 associated with fearfulness in dogs
Sarviaho, R., Hakosalo, O., Tiira, K., Sulkama, S., Niskanen, J. E., Hytönen, M. K., Sillanpää, M. J., & Lohi, H. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0849-z · Cited by 21 · see citing works
Ethical Concerns about Fashionable Dog Breeding
Menor-Campos, D. J. (2024) · Animals · doi:10.3390/ani14050756 · Cited by 20 · see citing works
“Aggression and fear are associated with the same genetic loci linked to small body size, as suggested by the correlation found in Zapata et al.’s studies [162,163].”
BackgroundFenner, K., Dashper, K. L., Serpell, J. A., McLean, A. N., Wilkins, C. L., Klinck, M. P., Wilson, B. J., & McGreevy, P. D. (2020) · Animals · doi:10.3390/ani10111960 · Cited by 20 · see citing works
Self-citationGenetic parameter and breeding value estimation of donkeys' problem-focused coping styles
González, F. J. N., Jordana, J., Jurado, J. M. L., Arbulu, A. A., McLean, A., & Bermejo, J. V. D. (2018) · Behavioural Processes · doi:10.1016/j.beproc.2018.05.008 · Cited by 19 · see citing works
Genome wide association study of 40 clinical measurements in eight dog breeds
Momozawa, Y., Merveille, A., Battaille, G., Wiberg, M. E., Koch, J., Willesen, J. L., Proschowsky, H. F., Gouni, V., Chetboul, V., Tiret, L., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-63457-y · Cited by 19 · see citing works
Benítez‐Burraco, A., Chekalin, E., Bruskin, S. A., Tatarinova, T. V., & Morozova, I. (2021) · Annals of Human Biology · doi:10.1080/03014460.2021.1936634 · Cited by 18 · see citing works
Li, T., Jin, M., Wang, H., Zhang, W., Yuan, Z., & Wei, C. (2024) · Animals · doi:10.3390/ani14050687 · Cited by 19 · see citing works
van der Borg, J. A. M., Graat, E. A. M., & Beerda, B. (2017) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2017.06.004 · Cited by 17 · see citing works
Витальевна, Ч. И., Ponomarenko, P. M., Рассказов, Д. А., Sharypova, E. B., Kashina, E. V., Kleshchev, M. A., Ponomarenko, M. P., Naumenko, V. S., Savinkova, L. K., Kolchanov, N. A., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00073 · Cited by 16 · see citing works
Binversie, E. E., Momen, M. M., Rosa, G. J. M., Davis, B. W., & Muir, P. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.913354 · Cited by 16 · see citing works
Doane, M., & Sarenbo, S. (2019) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2019.02.012 · Cited by 16 · see citing works
Eyre, A. W., Zapata, I., Hare, E., Serpell, J. A., Otto, C. M., & Alvarez, C. E. (2023) · Scientific Reports · doi:10.1038/s41598-023-39112-7 · Cited by 14 · see citing works
Self-citationAn exome sequencing based approach for genome-wide association studies in the dog
Broeckx, B. J. G., Derrien, T., Mottier, S., Wucher, V., Cadieu, É., Hédan, B., Béguec, C. L., Botherel, N., Lindblad‐Toh, K., Saunders, J. H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15947-9 · Cited by 14 · see citing works
Витальевна, Ч. И., Ponomarenko, P. M., Kozhemyakina, R. V., Suslov, V. V., Bogomolov, A. G., Klimova, N. V., Шихевич, С. Г., Savinkova, L. K., Oshchepkov, D. Y., Kolchanov, N. A., et al. (2021) · Animals · doi:10.3390/ani11092667 · Cited by 14 · see citing works
Zapata, I., Hecht, E. E., Serpell, J. A., & Alvarez, C. E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.19.211078 · Cited by 15 · see citing works
Self-citationCobb, M., Jiménez, A. G., & Dreschel, N. A. (2025) · Journal of Applied Animal Welfare Science · doi:10.1080/10888705.2025.2572616 · Cited by 20 · see citing works
Bogaerts, E., Moons, C. P. H., Nieuwerburgh, F. V., Peelman, L. J., Saunders, J. H., & Broeckx, B. J. G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218339 · Cited by 13 · see citing works
Influence of early life adversity and breed on aggression and fear in dogs
Espinosa, J., Zapata, I., Alvarez, C. E., Serpell, J. A., Kukekova, A. V., & Hecht, E. E. (2025) · Scientific Reports · doi:10.1038/s41598-025-18226-0 · Cited by 12 · see citing works
Self-citationGenetic dissection of behavioral traits related to successful training of drug detection dogs
Matsumoto, Y., Konno, A., Ishihara, G., & Inoue‐Murayama, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-33638-6 · Cited by 12 · see citing works
Baslington-Davies, A., Howell, H., Hogue, T. E., & Mills, D. S. (2023) · Animals · doi:10.3390/ani13142329 · Cited by 12 · see citing works
Resilience In Dogs? Lessons From Other Species
Tiira, K. (2019) · Veterinary Medicine Research and Reports · doi:10.2147/vmrr.s189566 · Cited by 12 · see citing works
Genome scanning of behavioral selection in a canine olfactory detection breeding cohort
Eyre, A. W., Zapata, I., Hare, E., Lee, K. M. N., Bellis, C., Essler, J. L., Otto, C. M., Serpell, J. A., & Alvarez, C. E. (2022) · Scientific Reports · doi:10.1038/s41598-022-18698-4 · Cited by 12 · see citing works
Self-citationPerspectives on two temperamental biases
Kagan, J. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0158 · Cited by 11 · see citing works
Blades, M., Freyer, J., Donner, J., Foran, R. C., & Forman, O. P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267604 · Cited by 11 · see citing works
Association of DNA methylation with energy and fear-related behaviors in canines
Sanders, A. R., Bhongir, N., vonHoldt, B. M., & Pellegrini, M. A. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1025494 · Cited by 11 · see citing works
Oshchepkov, D. Y., Ponomarenko, M. P., Klimova, N. V., Витальевна, Ч. И., Олегович, Б. А., Sharypova, E. B., Шихевич, С. Г., & Kozhemyakina, R. V. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01267 · Cited by 10 · see citing works
Short-term imepitoin treatment reduces stress level in dogs with generalized anxiety disorder
Forster, B., Engel, O., Erhard, M., & Bartels, A. (2020) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2020.05.006 · Cited by 10 · see citing works
Ponomarenko, M. P., Kleshchev, M. A., Ponomarenko, P. M., Витальевна, Ч. И., Sharypova, E. B., Рассказов, Д. А., Kolmykov, S. K., Drachkova, I. A., Vasiliev, G. V., Gutorova, N., et al. (2020) · BMC Genetics · doi:10.1186/s12863-020-00896-6 · Cited by 11 · see citing works
Carrier, L. O., Ricketts, C. J., Perry, E. A., Anderson, R. E., & Walsh, C. J. (2016) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2016.12.011 · Cited by 9 · see citing works
Ma, Z., Chang, Y., Brito, L. F., Li, Y., Yang, T. P., Wang, Y., & Yang, N. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23462 · Cited by 8 · see citing works
Zaldívar‐López, S., Rowell, J., Fiala, E. M., Zapata, I., Couto, C. G., & Alvarez, C. E. (2017) · BMC Genomics · doi:10.1186/s12864-017-3513-0 · Cited by 8 · see citing works
Self-citationPharmacotherapeutics in clinical ethology: treatment efficacy, clinical pathology and outcome
Overall, K. L. (2021) · Behaviour · doi:10.1163/1568539x-bja10096 · Cited by 8 · see citing works
Can laboratory animals violate behavioural norms? Towards a preclinical model of conduct disorder
Macrı̀, S., Zoratto, F., Chiarotti, F., & Giovanni Laviola, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.047 · Cited by 8 · see citing works
Peťková, B., Skurková, L., Florián, M., Slivková, M., Kasičová, Z., & Kottferová, J. (2024) · Animals · doi:10.3390/ani14182695 · Cited by 8 · see citing works
Vasiliev, G., Chadaeva, I., Rasskazov, D., Ponomarenko, P., Sharypova, E., Drachkova, I., Bogomolov, A., Savinkova, L., Ponomarenko, M., Kolchanov, N., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052346 · Cited by 7 · see citing works
Pritchett, M. E., Barnard, S., & Croney, C. (2021) · Animals · doi:10.3390/ani11030890 · Cited by 7 · see citing works
Bennett, N. E., Torres, S. E. M., & Gray, P. B. (2022) · PLoS ONE · doi:10.1371/journal.pone.0261694 · Cited by 7 · see citing works
Síndrome de Ansiedade por Separação em Animais de Companhia: Uma Revisão
Machado, D. D. S., & Sant’Anna, A. C. (2017) · Revista Brasileira de Zoociências · doi:10.34019/2596-3325.2017.v18.24682 · Cited by 7 · see citing works
The Shepherd and the Hunter: A Genomic Comparison of Italian Dog Breeds
Bionda, A., Cortellari, M., Liotta, L., & Crepaldi, P. (2023) · Animals · doi:10.3390/ani13152438 · Cited by 6 · see citing works
Potential Adaptive Introgression From Dogs in Iberian Grey Wolves ( Canis lupus )
Sarabia, C., Salado, I., Fernández‐Gil, A., vonHoldt, B. M., Hofreiter, M., Vilà, C., & Leonard, J. A. (2025) · Molecular Ecology · doi:10.1111/mec.17639 · Cited by 6 · see citing works
Витальевна, Ч. И., Рассказов, Д. А., Sharypova, E. B., Savinkova, L. K., Ponomarenko, P. M., & Ponomarenko, M. P. (2017) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059717050045 · Cited by 6 · see citing works
Breed function and behaviour correlate with endocranial volume in domestic dogs
Balcarcel, A. M., Sánchez-Villagra, M. R., Evin, A., Nussbaumer, M., Hemelsdaël, A., & Geiger, M. (2024) · Biology Letters · doi:10.1098/rsbl.2024.0342 · Cited by 5 · see citing works
Bhowmik, N., Cook, S. R., Croney, C., Barnard, S., Romaniuk, A. C., & Ekenstedt, K. J. (2024) · Genes · doi:10.3390/genes15121611 · Cited by 5 · see citing works
Benítez‐Burraco, A. (2019) · Molecular Syndromology · doi:10.1159/000505116 · Cited by 4 · see citing works
Polasik, D., Konieczna, A., Terman, A., & Dybus, A. (2021) · Acta Veterinaria Brno · doi:10.2754/avb202190030295 · Cited by 5 · see citing works
Are feralization and domestication truly mirror processes?
Niego, A., & Benítez‐Burraco, A. (2021) · Ethology Ecology & Evolution · doi:10.1080/03949370.2021.1975314 · Cited by 5 · see citing works
Veterinary education and experience shape beliefs about dog breeds. Part 2: Trust
Caddiell, R. M. P., White, P. A., Lascelles, B. D. X., Royal, K. D., Heugten, K. A., & Gruen, M. E. (2023) · Scientific Reports · doi:10.1038/s41598-023-40464-3 · Cited by 4 · see citing works
Fagen, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-7020-8214-6.00026-7 · Cited by 4 · see citing works
Mahmoodi, M. S., Mehrgardi, A. A., Momen, M. M., Serpell, J. A., & Esmailizadeh, A. (2024) · The Veterinary Journal · doi:10.1016/j.tvjl.2024.106251 · Cited by 4 · see citing works
Self-citationAn Evolutionary Perspective on Dog Behavioral Genetics
Lord, K. A., Chen, F. L., & Karlsson, E. K. (2024) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-111523-101954 · Cited by 5 · see citing works
Dog behaviour : Intricate picture of genetics, epigenetics, and human-dog relations
Sundman, A.-S. (2019) · Linköping studies in science and technology. Dissertations · doi:10.3384/diss.diva-156353 · Cited by 4 · see citing works
Adaptation in the Alleyways: Candidate Genes Under Potential Selection in Urban Coyotes
Kreling, S. E. S., Vance, S. E., & Carlen, E. J. (2024) · Genome Biology and Evolution · doi:10.1093/gbe/evae279 · Cited by 3 · see citing works
Alex, E., Gennotte, P., Morros-Nuevo, A., Yu, Y., Keep, B., Sullivan, M., Mills, D. S., Warrier, V., & Raffan, E. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2421757122 · Cited by 3 · see citing works
Wray, R. E., Barton, S. A., & Hecht, E. E. (2026) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2026.106959 · Cited by 3 · see citing works
Study of Behavioural Traits in Can de Palleiro (Galician Shepherd Dog)
de Miguel, S. M., Diéguez, F. J., da Silva-Monteiro, J. P., Ferreiro-Mazón, B. P., & González‐Martínez, Á. (2021) · Animals · doi:10.3390/ani11113198 · Cited by 3 · see citing works
Genomic analysis of firework fear and noise reactivity in standard poodles
Handegård, K. W., Storengen, L. M., Joergensen, D., & Lingaas, F. (2023) · Canine Medicine and Genetics · doi:10.1186/s40575-023-00125-0 · Cited by 3 · see citing works
Koller, D., Benítez‐Burraco, A., & Polimanti, R. A. (2023) · Human Genetics · doi:10.1007/s00439-023-02541-5 · Cited by 3 · see citing works
Animal welfare issues in space settlement expeditions
Pozzebon, M. (2024) · Futures · doi:10.1016/j.futures.2024.103443 · Cited by 3 · see citing works
CyberGenomics: Application of Behavioral Genetics in Cybersecurity
Domarkienė, I., Ambrozaitytė, L., Bukauskas, L., Rančelis, T., Sütterlin, S., Knox, B. J., Maennel, K., Maennel, O., Parish, K., Lugo, R. G., et al. (2021) · Behavioral Sciences · doi:10.3390/bs11110152 · Cited by 3 · see citing works
Abnormal features of human self‐domestication in bipolar disorder
Benítez‐Burraco, A., & Hansen, E. J. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15959 · Cited by 2 · see citing works
Behavioral Genetics of Dog Breeds
van Rooy, D., & Wade, C. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.90059-1 · Cited by 3 · see citing works
Nanaei, H. A., Ghanatsaman, Z. A., Farahvashi, M. A., Mousavi, S. F., Banabazi, M. H., & Fozi, M. A. (2024) · Tropical Animal Health and Production · doi:10.1007/s11250-024-04002-1 · Cited by 2 · see citing works
Masson, S., Bleuer‐Elsner, S., Muller, G., Médam, T., Chevallier, J., & Gaultier, E. (2024) · Springer eBooks · doi:10.1007/978-3-031-53012-8_8 · Cited by 2 · see citing works
- Authors
- Zapata, I., Serpell, J. A., & Alvarez, C. E.
- Affiliations
- Nationwide Children's Hospital (US)
- University of Pennsylvania (US)
- Corresponding author
- Alvarez, Carlos E.
- Venue
- BMC Genomics
- Published
- 2016-08-08
- Volume
- 17
- Issue
- 1
- Pages
- 572-572
- ISSN
- 1471-2164 (ISSN-L)
- PMC
- PMC4977763
- OpenAlex
- W2518047727
- Cited by
- 168
- References
- 80
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 19 · 2023: 26 · 2022: 20 · 2021: 14 · 2020: 16 · 2019: 18 · 2018: 11 · 2017: 10 · 2016: 3
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Genomics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Congressionally Directed Medical Research Programs (W81XWH-11-2-0224)
- American Kennel Club Canine Health Foundation (01660)
- Morris Animal Foundation (D13CA-073)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Human-Animal Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- insulin-like growth factor I, HMGA2, IGSF1, separation anxiety, tactile sensitivity, sociability, amygdala, hypothalamic-pituitary-adrenal axis
- MeSH terms
- Aggression, Alleles, Animals, Behavior, Animal, Breeding, Chromosome Mapping, Dogs, Fear, Haplotypes, Linkage Disequilibrium, Genome, Genome-Wide Association Study, Genetic Association Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
