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Mucins in cancer: function, prognosis and therapy
Open accessAbstract
Epithelia are protected from adverse conditions by a mucous barrier. The secreted and transmembrane mucins that constitute the mucous barrier are largely unrecognized as effectors of carcinogenesis. However, both types of mucins are intimately involved in inflammation and cancer. Moreover, diverse human malignancies overexpress transmembrane mucins to exploit their role in signalling cell growth and survival. Mucins have thus been identified as markers of adverse prognosis and as attractive therapeutic targets. Notably, the findings that certain transmembrane mucins induce transformation and promote tumour progression have provided the experimental basis for demonstrating that inhibitors of their function are effective as anti-tumour agents in preclinical models.
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Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364
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Polyak, K., & Weinberg, R. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2620 · Cited by 3,302
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Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
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Cited by
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Homayun, B., Lin, X., & Choi, H.-J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030129 · Cited by 837
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
Paszek, M. J., DuFort, C. C., Rossier, O., Bainer, R., Mouw, J. K., Godula, K., Hudak, J. E., Lakins, J. N., Wijekoon, A. C., Cassereau, L., et al. (2014) · Nature · doi:10.1038/nature13535 · Cited by 699
Extracellular fluid viscosity enhances cell migration and cancer dissemination
Bera, K., Kiepas, A., Godet, I., Li, Y., Mehta, P., Ifemembi, B., Paul, C. D., Sen, A., Serra, S. A., Stoletov, K., et al. (2022) · Nature · doi:10.1038/s41586-022-05394-6 · Cited by 412
Sweet escape: Sialic acids in tumor immune evasion
Büll, C., den Brok, M. H., & Adema, G. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.07.005 · Cited by 158
MUC1 (CD227): a multi-tasked molecule
Apostolopoulos, V., Stojanovska, L., & Gargosky, S. E. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2014-z · Cited by 138
Metadata
- Authors
- Kufe, D. W.
- Venue
- Nature Reviews Cancer
- Published
- 2009-12
- Volume
- 9
- Issue
- 12
- Pages
- 874-885
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1996344455
- Cited by
- 1,396
- References
- 5
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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