The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Megabase-Scale Inversion Polymorphism in the Wild Ancestor of Maize
Open accessAbstract
Chromosomal inversions are thought to play a special role in local adaptation, through dramatic suppression of recombination, which favors the maintenance of locally adapted alleles. However, relatively few inversions have been characterized in population genomic data. On the basis of single-nucleotide polymorphism (SNP) genotyping across a large panel of Zea mays, we have identified an ∼50-Mb region on the short arm of chromosome 1 where patterns of polymorphism are highly consistent with a polymorphic paracentric inversion that captures >700 genes. Comparison to other taxa in Zea and Tripsacum suggests that the derived, inverted state is present only in the wild Z. mays subspecies parviglumis and mexicana and is completely absent in domesticated maize. Patterns of polymorphism suggest that the inversion is ancient and geographically widespread in parviglumis. Cytological screens find little evidence for inversion loops, suggesting that inversion heterozygotes may suffer few crossover-induced fitness consequences. The inversion polymorphism shows evidence of adaptive evolution, including a strong altitudinal cline, a statistical association with environmental variables and phenotypic traits, and a skewed haplotype frequency spectrum for inverted alleles.
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“More often, hybrids heterozygous for inversions, especially for inversions that are polymorphic within species, do not show visible reductions in fertility (Kianian and Quiros, 1992; Lowry and Willis, 2010; Fang et al., 2012; Stathos and Fishman, 2014; Ostevik et al., 2016; Huang et al., 2020).”
From Genomics of plant speciation (2023) · cites this paper as Fang et al., 2012
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Metadata
- Authors
- Fang, Z., Pyhäjärvi, T., Weber, A. L., Dawe, R. K., Glaubitz, J. C., González, J. D. J. S., Ross-Ibarra, C., Doebley, J., Morrell, P. L., & Ross-Ibarra, J.
- Affiliations
- University of Minnesota (US)
- University of California, Davis (US)
- University of Wisconsin–Madison (US)
- University of Georgia (US)
- Cornell University (US)
- Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Zapopan, Jalisco, Mexico CP45110
- Department of Plant Sciences and
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-07-01
- Volume
- 191
- Issue
- 3
- Pages
- 883-894
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- PMC
- PMC3389981
- OpenAlex
- W2125064018
- Cited by
- 104
- References
- 90
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 13 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 2
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Minnesota
- Division of Integrative Organismal Systems
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- chromosomal inversions, paracentric inversion, maize, Tripsacum, single nucleotide polymorphisms, chromosome 1, recombination suppression, local adaptation, altitudinal cline, adaptive evolution, inversion heterozygotes, domestication
- MeSH terms
- Alleles, Zea mays, Haplotypes, Chromosome Inversion, Polymorphism, Genetic, Time Factors, Evolution, Molecular, Polymorphism, Single Nucleotide, Chromosomes, Plant
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