The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
eat-2 and eat-18 Are Required for Nicotinic Neurotransmission in the Caenorhabditis elegans Pharynx
Abstract
Mutations in eat-2 and eat-18 cause the same defect in C. elegans feeding behavior: the pharynx is unable to pump rapidly in the presence of food. EAT-2 is a nicotinic acetylcholine receptor subunit that functions in the pharyngeal muscle. It is localized to the synapse between pharyngeal muscle and the main pharyngeal excitatory motor neuron MC, and it is required for MC stimulation of pharyngeal muscle. eat-18 encodes a small protein that has no homology to previously characterized proteins. It has a single transmembrane domain and a short extracellular region. Allele-specific genetic interactions between eat-2 and eat-18 suggest that EAT-18 interacts physically with the EAT-2 receptor. While eat-2 appears to be required specifically for MC neurotransmission, eat-18 also appears to be required for the function of other nicotinic receptors in the pharynx. In eat-18 mutants, the gross localization of EAT-2 at the MC synapse is normal, suggesting that it is not required for trafficking. These data indicate that eat-18 could be a novel component of the pharyngeal nicotinic receptor.
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Cites
The pharynx of Caenorhabditis elegans
Albertson, D. G., & Thompson, J. N. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0085 · Cited by 649
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Shtonda, B. B., & Avery, L. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.01955 · Cited by 431
Self-citationMelzer, D., Pilling, L. C., & Ferrucci, L. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-019-0183-6 · Cited by 363
Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants
Bansal, A., Zhu, L. J., Yen, K., & Tissenbaum, H. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412192112 · Cited by 367
The neuronal genome of Caenorhabditis elegans
Hobert, O. (2013) · WormBook · doi:10.1895/wormbook.1.161.1 · Cited by 279
Probiotic Bacillus subtilis protects against α-synuclein aggregation in C. elegans
Goya, M. E., Xue, F., Sampedro-Torres-Quevedo, C., Arnaouteli, S., Riquelme-Dominguez, L., Romanowski, A., Brydon, J., Ball, K. L., Stanley-Wall, N. R., & Doitsidou, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.078 · Cited by 205
Metadata
- Authors
- McKay, J. P., Raizen, D. M., Gottschalk, A., Schafer, W. R., & Avery, L.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-01-01
- Volume
- 166
- Issue
- 1
- Pages
- 161-169
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2141345677
- Cited by
- 183
- References
- 1
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- McKay, J. P., Raizen, D. M., Gottschalk, A., Schafer, W. R., & Avery, L. (2004). eat-2 and eat-18 Are Required for Nicotinic Neurotransmission in the Caenorhabditis elegans Pharynx. Genetics. https://doi.org/10.1534/genetics.166.1.161
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