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Cited by 11Medicinal Plants and NeuroprotectionMedicinal Plant Extracts EffectsMedicinal Plant Research

Antiamnesic Activity of Extracts and Fraction of Desmodium Gangeticum

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Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147 002, Punjab, India, Mahajan, Kritika, Kumar, Deepak, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147 002, Punjab, India, Kumar, Suresh, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147 002, Punjab, India·2015·Journal of Pharmaceutical Technology Research and Management
DOI 10.15415/jptrm.2015.31006
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Abstract

Desmodium gangeticum D.C. (Salpani; family – Papilionaceae) has been traditionally used in the treatment of various ailments especially in dementia. Thus, it was planned to screen antiamnesic activity of D. gangeticum to validate its traditional claims. Properly identified powdered plant material was extracted successively using solvents in increasing order of polarity viz., n-hexane, chloroform, methanol and water. All the extracts were administered at the doses of 200 or 400 mg/kg, p.o. for six successive days to mice. The antiamnesic activity of crude extracts was evaluated against scopolamine (0.6 mg/kg, i.p.) induced amnesia using well established exteroceptive behavioural model, i.e., elevated plus maze (EPM). The efficacy of test drugs was statistically compared with the standard memory enhancing drug, piracetam (100 mg/kg, p.o.). A standardized procedure was adopted to prepare alkaloidal fraction from D. gangeticum roots, which was also evaluated for antiamnesic activity at the doses of 25 or 50 mg/kg, p.o. The chloroform extract and alkaloidal fraction of the plant significantly reversed the amnesia induced by the scopolamine at the dose of 400 and 50 mg/kg, respectively, with respect to control. The antiamnesic activity shown by the chloroform extract and alkaloidal fraction of the plant was statistically equivalent to the standard drug. It is concluded that alkaloids are responsible for antiamnesic activity of D. gangeticum roots.

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Research works printed but not linked: 4

  1. Anonymous. (2001). The Wealth of India: A Dictionary of Indian Raw Materials and Industrial Products: First Supplement Series (Raw Materials). Vol. 2, National Institute of Science Communication and Research, New Delhi, India.
  2. Chuong, N.N., Trung, B.H., Luan, T.C., Hung, T.M., Dang, N.H. & Dat, N.T. (2014). Antiamnesic effect of alkaloid fraction from Lycopodiella cernua (L.) Pic. Serm. on scopolamineinduced memory impairment in mice. Neuroscience Letters, 575, 42-46. http://dx.doi.org/10.1016/j. neulet.2014.05.031. · DOI
  3. Scheffer, W.C. (1980). Statistics for the Biological Sciences. 32nd edition, Addison-Wesley Publishing Company, Philippines.
  4. Kritika Mahajan, Deepak Kumar, Suresh Kumar. Antiamnesic Activity of Extracts and Fraction of Desmodium Gangeticum. J. Pharm. Technol. Res. Manag.. 2015, 03, 67-77

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Authors
Department of Pharmaceutical Sciences and Drug Research, P. U., Mahajan, K., Kumar, D., Department of Pharmaceutical Sciences and Drug Research, P. U., Kumar, S., & Department of Pharmaceutical Sciences and Drug Research, P. U.
Affiliations
Punjabi University (IN)
ORCID
Venue
Journal of Pharmaceutical Technology Research and Management
Publisher
Chitkara University Publications
Published
2015-05-20
Volume
3
Issue
1
Pages
67-77
ISSN
  • 2321-2217 (ISSN-L)
  • 2321-2225
DOI
10.15415/jptrm.2015.31006
OpenAlex
W2470330393
Cited by
11
References
29
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 2
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
Journal of Pharmaceutical Technology Research and Management (publishedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
Desmodium gangeticum, antiamnesic activity, scopolamine-induced amnesia, elevated plus maze, memory enhancement, alkaloids, chloroform extract, root extract, piracetam, traditional medicine, dementia

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