Antiamnesic Effects of Desmodium gangeticum in Mice

JOSHI, Hanumanthachar; PARLE, Milind

doi:10.1248/yakushi.126.795

Cited by 70Medicinal Plants and NeuroprotectionMedicinal Plant Extracts EffectsAntioxidants, Aging, Portulaca oleracea

Antiamnesic Effects of Desmodium gangeticum in Mice

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JOSHI, Hanumanthachar, PARLE, Milind·2006·YAKUGAKU ZASSHI

DOI 10.1248/yakushi.126.795

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Abstract

Dementia is a mental disorder characterized by loss of intellectual ability sufficiently severe enough to interfere with one's occupational or social activities. Desmodium gangeticum commonly known as Salparni, is widely used in ayurveda for the treatment of neurological disorders. The present work was designed to assess the potential of aqueous extract of D. gangeticum (DG) as a nootropic agent in mice. DG (50, 100 and 200 mg/kg, p.o.) was administered for 7 successive days to both young and older mice. Exteroceptive behavioral models such as elevated plus maze and passive avoidance paradigm were employed to evaluate learning and memory. Scopolamine (0.4 mg/kg, i.p.) induced amnesia and ageing induced amnesia were the interoceptive behavioral models. To delineate the mechanism by which DG exerts nootropic activity, the effect of DG on whole brain AChE activity was also assessed. Piracetam (200 mg/kg, i.p.) was used as a standard nootropic agent. Pretreatment with DG (50, 100 and 200 mg/kg p.o.) for seven successive days significantly improved learning and memory in mice and reversed the amnesia induced by both, scopolamine (0.4 mg/kg, i.p.) and natural ageing. DG also decreased whole brain acetyl cholinesterase activity. Hence, D. gangeticum appears to be a promising candidate for improving memory and it would be worthwhile to explore the potential of this plant in the management of dementia and Alzheimer disease.

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Aqueous extract of D. gangeticum when administered orally at the dose of 50, 100 and 200 mg/kg for 7 days improved memory in mice.
“Aqueous extract of D. gangeticum when administered orally at the dose of 50, 100 and 200 mg/kg for 7 days improved memory in mice [198,199].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [198]
Scopolamine and ageing induced amnesias were prevented in rats by pretreatment with the aqueous extract of D. gangeticum.
“Scopolamine and ageing induced amnesias were also prevented in rats by pretreatment with the aqueous extract of D. gangeticum [198].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [198]

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Authors: JOSHI, H., & PARLE, M.
Affiliations: Department of Pharmacognosy, SET'S College of Pharmacy
Guru Jambheshwar University of Science and Technology (IN)
ORCID: JOSHI, Hanumanthachar
Venue: YAKUGAKU ZASSHI
Publisher: Pharmaceutical Society of Japan
Published: 2006-09-01
Volume: 126
Issue: 9
Pages: 795-804
ISSN: 0031-6903 (ISSN-L)
1347-5231
DOI: 10.1248/yakushi.126.795
OpenAlex: W2153434869
Cited by: 70
References: 32
Citations by year: 2026: 1 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 7 · 2013: 2 · 2012: 3
FWCI: 5.90
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: YAKUGAKU ZASSHI (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords: Desmodium gangeticum, nootropic activity, memory enhancement, learning, scopolamine-induced amnesia, acetylcholinesterase inhibition, Alzheimer's disease, dementia, Ayurveda, aqueous plant extract
MeSH terms: Acetylcholinesterase, Amnesia, Animals, Avoidance Learning, Behavior, Animal, Brain, Disease Models, Animal, Female, Fabaceae, Male, Medicine, Ayurvedic, Phytotherapy, Memory, Plant Extracts, Reaction Time, Nootropic Agents, Maze Learning, Mice

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Antiamnesic Effects of Desmodium gangeticum in Mice

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