The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Experience With the Ketogenic Diet in Infants
Abstract
Objective.: To evaluate the effectiveness, tolerability, and adverse effects of the ketogenic diet in infants with refractory epilepsy. Methods.: A retrospective review of 32 infants who had been treated with the ketogenic diet at a large metropolitan institution. Results.: Most infants (71%) were able to maintain strong ketosis. The overall effectiveness of the diet in infants was similar to that reported in the literature for older children; 19.4% became seizure-free, and an additional 35.5% had >50% reduction in seizure frequency. The diet was particularly effective for patients with infantile spasms/myoclonic seizures. There were concomitant reductions in antiepileptic medications. The majority of parents reported improvements in seizure frequency and in their child's behavior and function, particularly with respect to attention/alertness, activity level, and socialization. The diet generally was well-tolerated, and 96.4% maintained appropriate growth parameters. Adverse events, all reversible and occurring in one patient each, included renal stone, gastritis, ulcerative colitis, alteration of mentation, and hyperlipidemia. Conclusion.: The ketogenic diet should be considered safe and effective treatment for infants with intractable seizures.
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Cites
De Vivo, D. C., Trifiletti, R. R., Jacobson, R. I., Ronen, G. M., Behmand, R. A., & Harik, S. I. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109053251006 · Cited by 800
Self-citationThe Prevalence and Incidence of Convulsive Disorders in Children
Hauser, W. A. (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb05932.x · Cited by 684
The Efficacy of the Ketogenic Diet—1998: A Prospective Evaluation of Intervention in 150 Children
Freeman, J. M., Vining, E. P. G., Pillas, D. J., Pyzik, P. L., Casey, J. C., & Kelly, L. A. M. T. (1998) · Pediatrics · doi:10.1542/peds.102.6.1358 · Cited by 612
Chronic ketosis and cerebral metabolism
Devivo, D. C., Leckie, M. P., Ferrendelli, J. S., & McDougal, D. B. (1978) · Annals of Neurology · doi:10.1002/ana.410030410 · Cited by 281
Self-citationWexler, I. D., Hemalatha, S. G., McConnell, J., Buist, N. R. M., Dahl, H.-H. M., Berry, S. A., Cederbaum, S. D., Patel, M. S., & Kerr, D. S. (1997) · Neurology · doi:10.1212/wnl.49.6.1655 · Cited by 275
Efficacy of the Ketogenic Diet for Intractable Seizure Disorders: Review of 58 Cases
Kinsman, S. L., Vining, E. P. G., Quaskey, S. A., Mellits, D., & Freeman, J. M. (1992) · Epilepsia · doi:10.1111/j.1528-1157.1992.tb01770.x · Cited by 274
Complications of the Ketogenic Diet
Ballaban‐Gil, K., Callahan, C., O'Dell, C., Pappo, M., Moshé, S., & Shinnar, S. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01160.x · Cited by 203
Developmental Changes of Cerebral Ketone Body Utilization in Human Infants
Kraus, H., Schlenker, S., & Schwedesky, D. (1974) · Biological Chemistry · doi:10.1515/bchm2.1974.355.1.164 · Cited by 167
Appleton, D. B., & DeVivo, D. C. (1974) · Epilepsia · doi:10.1111/j.1528-1157.1974.tb04943.x · Cited by 163
Self-citationThe Ketogenic Diet Revisited: Back to the Future
Nordli, D. R., & Vivo, D. C. D. (1997) · Epilepsia · doi:10.1111/j.1528-1157.1997.tb01460.x · Cited by 133
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Cited by
Guerrini, R. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68182-8 · Cited by 848
Anticonvulsant Mechanisms of the Ketogenic Diet
Bough, K. J., & Rho, J. M. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.00915.x · Cited by 523
Wilmshurst, J. M., Gaillard, W. D., Vinayan, K. P., Tsuchida, T. N., Plouin, P., Van Bogaert, P., Carrizosa, J., Elia, M., Craiu, D., Jovic, N. J., et al. (2015) · Epilepsia · doi:10.1111/epi.13057 · Cited by 418
Self-citationThe Ketogenic Diet: One Decade Later
Freeman, J. M., Kossoff, E. H., & Hartman, A. L. (2007) · Pediatrics · doi:10.1542/peds.2006-2447 · Cited by 364
Efficacy of the Ketogenic Diet as a Treatment Option for Epilepsy: Meta-analysis
Henderson, C. B., Filloux, F. M., Alder, S. C., Lyon, J. L., & Caplin, D. A. (2006) · Journal of Child Neurology · doi:10.2310/7010.2006.00044 · Cited by 264
Metadata
- Authors
- Nordli, D. R., Kuroda, M. M., Carroll, J., Koenigsberger, D. Y., Hirsch, L. J., Bruner, H. J., Seidel, W. T., & De Vivo, D. C.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2001-07-01
- Volume
- 108
- Issue
- 1
- Pages
- 129-133
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2131067316
- Cited by
- 304
- References
- 13
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nordli, D. R., Kuroda, M. M., Carroll, J., Koenigsberger, D. Y., Hirsch, L. J., Bruner, H. J., Seidel, W. T., & De Vivo, D. C. (2001). Experience With the Ketogenic Diet in Infants. Pediatrics. https://doi.org/10.1542/peds.108.1.129
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