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Cited by 322Food Allergy and Anaphylaxis ResearchPharmacovigilance and Adverse Drug ReactionsDrug-Induced Adverse Reactions

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Risk of anaphylaxis after vaccination of children and adolescents.

Bohlke, Kari, Davis, Robert L., Marcy, S. M., Braun, M. M., DeStefano, Frank, Black, Steven B., Mullooly, John P., Thompson, Robert S., for the Vaccine Safety Datalink Team·2003·PEDIATRICS
DOI 10.1542/peds.112.4.815
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Abstract

OBJECTIVE: To quantify the risk of anaphylaxis after vaccination of children and adolescents. METHODS: The study population consisted of children and adolescents who were enrolled at 4 health maintenance organizations that participated in the Vaccine Safety Datalink Project. For the period 1991-1997, we identified potential cases by searching for occurrences of International Classification of Diseases, Ninth Revision (ICD-9) code 995.0 (anaphylactic shock), E948.0 through E948.9 (adverse reaction from bacterial vaccines), and E949.0 through E949.9 (adverse reaction from other vaccines and biological substances). At 1 study site, we also included a range of other allergy codes. We restricted to diagnoses on days 0 to 2 after vaccination (ICD-9 995.0) or day 0 (all other ICD-9 codes). We then reviewed the medical record to confirm the diagnosis. RESULTS: We identified 5 cases of potentially vaccine-associated anaphylaxis after administration of 7 644 049 vaccine doses, for a risk of 0.65 cases/million doses (95% confidence interval: 0.21-1.53). None of the episodes resulted in death. Vaccines that were administered before the anaphylactic episodes were generally given in combination and included measles-mumps-rubella, hepatitis B, diphtheria-tetanus, diphtheria-tetanus-pertussis, Haemophilus influenzae type b, and oral polio vaccine. One case of anaphylaxis followed measles-mumps-rubella vaccine alone. At the site at which we reviewed additional allergy codes, we identified 1 case after 653 990 vaccine doses, for a risk of 1.53 cases/million doses (95% confidence interval: 0.04-8.52). CONCLUSIONS: Patients and health care providers can be reassured that vaccine-associated anaphylaxis is a rare event. Nevertheless, providers should be prepared to provide immediate medical treatment should it occur.

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Crossref · 10.1542/peds.112.4.815

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Metadata

Authors
Bohlke, K., Davis, R. L., Marcy, S. M., Braun, M. M., DeStefano, F., Black, S. B., Mullooly, J. P., Thompson, R. S., & for the Vaccine Safety Datalink Team
Affiliations
  • Group Health Cooperative (US)
  • Kaiser Foundation Hospital (US)
  • Center for Biologics Evaluation and Research (US)
  • Centers for Disease Control and Prevention (US)
  • Kaiser Permanente (US)
ORCID
Venue
PEDIATRICS
Publisher
American Academy of Pediatrics (AAP)
Published
2003-10-01
Volume
112
Issue
4
Pages
815-820
ISSN
  • 0031-4005 (ISSN-L)
  • 1098-4275
DOI
10.1542/peds.112.4.815
OpenAlex
W2111371073
Cited by
320
References
24
Citations by year
2026: 2 · 2025: 7 · 2024: 9 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 5 · 2019: 14 · 2018: 16 · 2017: 11 · 2016: 16 · 2015: 17 · 2014: 16 · 2013: 14 · 2012: 25
FWCI
6.71
Type
journal article
Language
en
Open access
closed
Locations
  • PEDIATRICS (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Kaiser Permanente
  • Centers for Disease Control and Prevention
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
  • Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
Keywords
vaccine anaphylaxis, vaccine safety, children and adolescents, MMR vaccine, hepatitis B vaccine, diphtheria-tetanus vaccine, Haemophilus influenzae type b vaccine, oral polio vaccine, vaccine adverse events, anaphylactic shock
MeSH terms
Adolescent, Anaphylaxis, California, Child, Child, Preschool, Female, Health Maintenance Organizations, Humans, Infant, Infant, Newborn, Male, Oregon, Risk, Vaccination, Vaccines, Washington, Cohort Studies, Adverse Drug Reaction Reporting Systems

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