The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
How Reliable Is a Negative Blood Culture Result? Volume of Blood Submitted for Culture in Routine Practice in a Children's Hospital
Abstract
OBJECTIVES. The primary aims of this study were to determine the volume of blood submitted for culture in routine clinical practice and to establish the proportion of blood cultures with a blood volume inadequate for reliable detection of bacteremia. METHODS. The volumes of blood samples submitted for culture from infants and children up to 18 years of age were measured over a 6-month period. Blood cultures were deemed adequate submissions if they contained an appropriate (age-related) volume of blood and were submitted in the correct blood culture bottle type. During the study, an educational intervention designed to increase the proportion of adequate blood culture submissions was undertaken. RESULTS. The volume of blood submitted in 1358 blood culture bottles from 783 patients was analyzed. Of the 1067 preintervention blood cultures, 491 (46.0%) contained an adequate blood volume and only 378 (35.4%) were adequate submissions on the basis of collection into the correct blood culture bottle type. After the intervention, there were significant increases in both the proportion of blood cultures containing an adequate blood volume (186 [63.9%] of 291 cultures) and the proportion of adequate submissions (149 [51.2%] of 291 cultures). Overall, blood cultures with an adequate blood volume were more likely than those with an inadequate blood volume to yield positive blood culture results (34 [5.2%] of 655 cultures vs 14 [2.1%] of 648 cultures). Similarly, adequate blood culture submissions were more likely than inadequate submissions to yield positive blood culture results (26 [5.1%] of 506 cultures vs 22 [2.8%] of 797 cultures). CONCLUSIONS. In routine clinical practice, a negative blood culture result is almost inevitable for a large proportion of blood cultures because of the submission of an inadequate volume of blood. Even after an educational intervention, nearly one half of blood cultures were inadequate submissions.
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Cites
Bacteremia among Children Admitted to a Rural Hospital in Kenya
Berkley, J. A., Lowe, B. S., Mwangi, I., Williams, T., Bauni, E., Mwarumba, S., Ngetsa, C., Slack, M. P. E., Njenga, S., Hart, C. A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa040275 · Cited by 851
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Mermel, L. A., & Maki, D. G. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-4-199308150-00003 · Cited by 294
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BacT/Alert: an automated colorimetric microbial detection system
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Effects of volume and periodicity on blood cultures
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Cited by
Management of Neonates With Suspected or Proven Early-Onset Bacterial Sepsis
Polin, R. A., the COMMITTEE ON FETUS AND NEWBORN, Papile, L.-A., Baley, J. E., Bhutani, V. K., Carlo, W. A., Cummings, J., Kumar, P., Tan, R. C., Wang, K. S., et al. (2012) · Pediatrics · doi:10.1542/peds.2012-0541 · Cited by 802
Lehrnbecher, T., Phillips, R., Alexander, S., Alvaro, F., Carlesse, F., Fisher, B., Hakim, H., Santolaya, M., Castagnola, E., Davis, B. L., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.42.7161 · Cited by 353
Emerging Technologies for Molecular Diagnosis of Sepsis
Sinha, M., Jupe, J., Mack, H., Coleman, T. P., Lawrence, S. M., & Fraley, S. I. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00089-17 · Cited by 331
Ting, J. Y., Synnes, A., Roberts, A., Deshpandey, A., Dow, K., Yoon, E. W., Lee, K.-S., Dobson, S., Lee, S. K., Shah, P. S., et al. (2016) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2016.2132 · Cited by 266
Chan, G. J., Lee, A. C., Baqui, A. H., Tan, J., & Black, R. E. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001502 · Cited by 253
Metadata
- Authors
- Connell, T. G., Rele, M., Cowley, D., Buttery, J. P., & Curtis, N.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2007-05-01
- Volume
- 119
- Issue
- 5
- Pages
- 891-896
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2167626887
- Cited by
- 401
- References
- 19
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Connell, T. G., Rele, M., Cowley, D., Buttery, J. P., & Curtis, N. (2007). How Reliable Is a Negative Blood Culture Result? Volume of Blood Submitted for Culture in Routine Practice in a Children's Hospital. Pediatrics. https://doi.org/10.1542/peds.2006-0440
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