The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Baby Care Products: Possible Sources of Infant Phthalate Exposure
Abstract
OBJECTIVES. Phthalates are man-made chemicals found in personal care and other products. Recent studies suggest that some phthalates can alter human male reproductive development, but sources of infant exposure have not been well characterized. We investigated the relationship between phthalate metabolite concentrations in infant urine and maternal reported use of dermally applied infant care products. METHODS. We measured 9 phthalate metabolites in 163 infants who were born in 2000–2005. An infant was considered to have been exposed to any infant care product that the mother reported using on her infant within 24 hours of urine collection. Results of multiple linear regression analyses are reported as the ratio of metabolite concentrations (with 95% confidence intervals) in exposed and unexposed infants. We standardized concentrations by forming z scores and examined combined exposure to multiple metabolites. RESULTS. In most (81%) infants, ≥7 phthalate metabolites were above the limit of detection. Exposure to lotion was predictive of monoethyl phthalate and monomethyl phthalate concentrations, powder of monoisobutyl phthalate, and shampoo of monomethyl phthalate. Z scores increased with number of products used. Most associations were stronger in younger infants. CONCLUSIONS. Phthalate exposure is widespread and variable in infants. Infant exposure to lotion, powder, and shampoo were significantly associated with increased urinary concentrations of monoethyl phthalate, monomethyl phthalate, and monoisobutyl phthalate, and associations increased with the number of products used. This association was strongest in young infants, who may be more vulnerable to developmental and reproductive toxicity of phthalates given their immature metabolic system capability and increased dosage per unit body surface area.
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Cites
Estimation of Average Concentration in the Presence of Nondetectable Values
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Decrease in anogenital distance among male infants with prenatal phthalate exposure
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Human exposure to phthalates via consumer products
SCHETTLER, T. (2006) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00567.x · Cited by 1,083
What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?
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Silva, M. J., Barr, D. B., Reidy, J. A., Malek, N. A., Hodge, C. C., Caudill, S. P., Brock, J. W., Needham, L. L., & Calafat, A. M. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6723 · Cited by 966
Self-citationHauser, R., & Calafat, A. M. (2005) · Occupational and Environmental Medicine · doi:10.1136/oem.2004.017590 · Cited by 941
Self-citationMain, K. M., Mortensen, G. K., Kaleva, M. M., Boisen, K. A., Damgaard, I. N., Chellakooty, M., Schmidt, I. M., Suomi, A.-M., Virtanen, H. E., Petersen, J. H., et al. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8075 · Cited by 696
Phthalates in Indoor Dust and Their Association with Building Characteristics
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Semen quality in relation to biomarkers of pesticide exposure.
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Cited by
Phthalates and other additives in plastics: human exposure and associated health outcomes
Meeker, J. D., Sathyanarayana, S., & Swan, S. H. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0268 · Cited by 835
Self-citationReproductive and Developmental Toxicity of Phthalates
Lyche, J. L., Gutleb, A. C., Bergman, Å., Eriksen, G. S., Murk, A. J., Ropstad, E., Saunders, M., & Skaare, J. U. (2009) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400903094091 · Cited by 607
Phthalate exposure and children's health
Braun, J. M., Sathyanarayana, S., & Hauser, R. (2013) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32835e1eb6 · Cited by 386
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Metadata
- Authors
- Sathyanarayana, S., Karr, C. J., Lozano, P., Brown, E., Calafat, A. M., Liu, F., & Swan, S. H.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2008-02-01
- Volume
- 121
- Issue
- 2
- Pages
- e260-e268
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2165789888
- Cited by
- 266
- References
- 35
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- closed
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