The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Systemic Hypothermia After Neonatal Encephalopathy: Outcomes of neo.nEURO.network RCT
Abstract
OBJECTIVE: Mild hypothermia after perinatal hypoxic-ischemic encephalopathy (HIE) reduces neurologic sequelae without significant adverse effects, but studies are needed to determine the most-efficacious methods. METHODS: In the neo.nEURO.network trial, term neonates with clinical and electrophysiological evidence of HIE were assigned randomly to either a control group, with a rectal temperature of 37°C (range: 36.5–37.5°C), or a hypothermia group, cooled and maintained at a rectal temperature of 33.5°C (range: 33–34°C) with a cooling blanket for 72 hours, followed by slow rewarming. All infants received morphine (0.1 mg/kg) every 4 hours or an equivalent dose of fentanyl. Neurodevelopmental outcomes were assessed at the age of 18 to 21 months. The primary outcome was death or severe disability. RESULTS: A total of 129 newborn infants were enrolled, and 111 infants were evaluated at 18 to 21 months (53 in the hypothermia group and 58 in the normothermia group). The rates of death or severe disability were 51% in the hypothermia group and 83% in the normothermia group (P = .001; odds ratio: 0.21 [95% confidence interval [CI]: 0.09–0.54]; number needed to treat: 4 [95% CI: 3–9]). Hypothermia also had a statistically significant protective effect in the group with severe HIE (n = 77; P = .005; odds ratio: 0.17 [95% CI: 0.05–0.57]). Rates of adverse events during the intervention were similar in the 2 groups except for fewer clinical seizures in the hypothermia group. CONCLUSION: Systemic hypothermia in the neo.nEURO.network trial showed a strong neuroprotective effect and was effective in the severe HIE group.
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Palisano, R., Rosenbaum, P., Walter, S., Russell, D., Wood, E., & Galuppi, B. (1997) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1997.tb07414.x · Cited by 6,721
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmcps050929 · Cited by 2,862
Cooling for newborns with hypoxic ischaemic encephalopathy
Jacobs, S. E., Berg, M., Hunt, R., Tarnow-Mordi, W. O., Inder, T. E., & Davis, P. G. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003311.pub3 · Cited by 2,328
Gluckman, P. D., Wyatt, J. S., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., Polin, R. A., Robertson, C. M., Thoresen, M., Whitelaw, A., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17946-x · Cited by 2,270
Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy
Azzopardi, D. V., Strohm, B., Edwards, A. D., Dyet, L., Halliday, H. L., Juszczak, E., Kapellou, O., Levene, M., Marlow, N., Porter, E., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900854 · Cited by 1,710
Moderate hypothermia in neonatal encephalopathy: Efficacy outcomes
Eicher, D. J., Wagner, C. L., Katikaneni, L. P., Hulsey, T. C., Bass, W. T., Kaufman, D. A., Horgan, M. J., Languani, S., Bhatia, J. J., Givelichian, L. M., et al. (2005) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2004.06.014 · Cited by 581
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Assessment of Neonatal Encephalopathy by Amplitude-integrated Electroencephalography
al Naqeeb, N., Edwards, A. D., Cowan, F. M., & Azzopardi, D. (1999) · Pediatrics · doi:10.1542/peds.103.6.1263 · Cited by 458
Toet, M. C., Hellström-Westas, L., Groenendaal, F., Eken, P., & de Vries, L. S. (1999) · Archives of Disease in Childhood - Fetal and Neonatal Edition · doi:10.1136/fn.81.1.f19 · Cited by 442
Whole-Body Hypothermia for Neonates With Hypoxic???Ischemic Encephalopathy
Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., et al. (2006) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000201910.42613.6c · Cited by 357
Cited by
Cooling for newborns with hypoxic ischaemic encephalopathy
Jacobs, S. E., Berg, M., Hunt, R., Tarnow-Mordi, W. O., Inder, T. E., & Davis, P. G. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003311.pub3 · Cited by 2,328
Lee, A. C., Kozuki, N., Blencowe, H., Vos, T., Bahalim, A., Darmstadt, G. L., Niermeyer, S., Ellis, M., Robertson, N. J., Cousens, S., et al. (2013) · Pediatric Research · doi:10.1038/pr.2013.206 · Cited by 665
Weeke, L. C., Groenendaal, F., Mudigonda, K., Blennow, M., Lequin, M. H., Meiners, L. C., van Haastert, I. C., Benders, M. J., Hallberg, B., & de Vries, L. S. (2018) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.09.043 · Cited by 260
Hypoxic-Ischemic encephalopathy and therapeutic hypothermia: the hemodynamic perspective
Giesinger, R. E., Bailey, L. J., Deshpande, P., & McNamara, P. J. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.09.009 · Cited by 92
Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art
Chakkarapani, E., de Vries, L. S., Ferriero, D. M., & Gunn, A. J. (2025) · Pediatric Research · doi:10.1038/s41390-025-03986-2 · Cited by 90
Metadata
- Authors
- Simbruner, G., Mittal, R. A., Rohlmann, F., Muche, R., & neo.nEURO.network Trial Participants
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2010-10-01
- Volume
- 126
- Issue
- 4
- Pages
- e771-e778
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2162755743
- Cited by
- 474
- References
- 20
- FWCI
- 27.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Simbruner, G., Mittal, R. A., Rohlmann, F., Muche, R., & neo.nEURO.network Trial Participants. (2010). Systemic Hypothermia After Neonatal Encephalopathy: Outcomes of neo.nEURO.network RCT. Pediatrics. https://doi.org/10.1542/peds.2009-2441
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