Cited by 242Gastrointestinal motility and disordersProbiotics and Fermented FoodsGut microbiota and health

The DOI matches its Crossref record; 44 of the 46 references it cites were found in a registry or an index.

A Randomized Controlled Trial of Lactobacillus GG in Children With Functional Abdominal Pain

Francavilla, Ruggiero, Miniello, Vito, Magistà, Anna Maria, De Canio, Angela, Bucci, Nunzia, Gagliardi, Francesca, Lionetti, Elena, Castellaneta, Stefania, Polimeno, Lorenzo, Peccarisi, Lucia, Indrio, Flavia, Cavallo, Luciano·2010·Pediatrics

DOI 10.1542/peds.2010-0467

Open this paper in CoChat — free account

Abstract

OBJECTIVE: Our aim was to determine whether Lactobacillus rhamnosus GG (LGG) relieves symptoms in children with recurrent abdominal pain. PATIENTS AND METHODS: A total of 141 children with irritable bowel syndrome (IBS) or functional pain were enrolled in 9 primary care sites and a referral center. Children entered a randomized, double-blind, placebo-controlled trial and received LGG or placebo for 8 weeks and entered follow-up for 8 weeks. The primary outcome was overall pain at the end of the intervention period. At entry and at the end of the trial, children underwent a double-sugar intestinal permeability test. RESULTS: Compared with baseline, LGG, but not placebo, caused a significant reduction of both frequency (P < .01) and severity (P < .01) of abdominal pain. These differences still were significant at the end of follow-up (P < .02 and P < .001, respectively). At week 12, treatment success was achieved in 48 children in the LGG group compared with 37 children in the placebo group (P < .03); this difference still was present at the end of follow-up (P < .03). At entry, 59% of the children had abnormal results from the intestinal permeability test; LGG, but not placebo, determined a significant decrease in the number of patients with abnormal results from the intestinal permeability testing (P < .03). These effects mainly were in children with IBS. CONCLUSIONS: LGG significantly reduces the frequency and severity of abdominal pain in children with IBS; this effect is sustained and may be secondary to improvement of the gut barrier.

Integrity signals

Registry

Crossref · 10.1542/peds.2010-0467

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

3 retracted

Pharmacological interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood
Huertas‐Ceballos, A., Logan, S., Bennett, C., & Macarthur, C. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003017.pub2 · Cited by 210
Retracted
Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood
Huertas‐Ceballos, A., Logan, S., Bennett, C., Macarthur, C., & Martin, A. E. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003019.pub4 · Cited by 109
Retracted
Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood
Huertas‐Ceballos, A., Logan, S., Bennett, C., & Macarthur, C. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003019.pub2 · Cited by 49
Retracted
Childhood Functional Gastrointestinal Disorders: Child/Adolescent
Rasquin, A., Lorenzo, C. D., Forbes, D., Guiraldes, E., Hyams, J. S., Staiano, A., & Walker, L. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.063 · Cited by 1,804
Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
Probiotic bacteria enhance murine and human intestinal epithelial barrier function
Madsen, K., Cornish, A. S., Soper, P., McKaigney, C. J., Jijon, H. B., Yachimec, C., Doyle, J. S. G., Jewell, L. D., & Simone, C. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.27224 · Cited by 1,096
The Fecal Microbiota of Irritable Bowel Syndrome Patients Differs Significantly From That of Healthy Subjects
Kassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002
Childhood functional gastrointestinal disorders
Weber, A. M., Hyman, P. E., Cucchiara, S., Fleisher, D. R., Hyams, J. S., Milla, P. J., & Staiano, A. (1999) · Gut · doi:10.1136/gut.45.2008.ii60 · Cited by 815
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793
A new analogue scale for assessing children's pain: an initial validation study
McGrath, P. A., Seifert, C. E., Speechley, K. N., Booth, J. C., Stitt, L., & Gibson, M. C. (1996) · Pain · doi:10.1016/0304-3959(95)00171-9 · Cited by 558

Flagged first, then by citations

Show all 46 references

2 of the 46 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–200 of 242

Functional Nausea in Children: A Review of the Literature and Need for Diagnostic Criteria
Russell, A. C., Stone, A. L., & Walker, L. S. (2016) · Children · doi:10.3390/children3010005 · Cited by 22
Lactobacillus rhamnosus GG Stimulates Dietary Tryptophan-Dependent Production of Barrier-Protecting Methylnicotinamide
Suntornsaratoon, P., Antonio, J. M., Flores, J., Upadhyay, R., Veltri, J., Bandyopadhyay, S., Dadala, R., Kim, M., Liu, Y., Balasubramanian, I., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.04.003 · Cited by 23
Functional Abdominal Pain in Childhood: Background Studies and Recent Research Trends
Levy, R. L., & van Tilburg, M. A. L. (2012) · Pain Research and Management · doi:10.1155/2012/960104 · Cited by 22
Probiotics for paediatric functional abdominal pain disorders: A rapid review
Ding, F. C. L., Karkhaneh, M., Zorzela, L., Jou, H., & Vohra, S. (2019) · Paediatrics & Child Health · doi:10.1093/pch/pxz036 · Cited by 19
Efficacy of probiotic adjuvant therapy for irritable bowel syndrome in children: A systematic review and meta-analysis
Xu, H.-L., Zou, L., Chen, M.-B., Wang, H. X., Shen, W.-M., Zheng, Q.-H., & Cui, W.-Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255160 · Cited by 22
Intestinal Permeability in Children with Functional Gastrointestinal Disorders: The Effects of Diet
Giorgio, V., Margiotta, G., Stella, G., Cicco, F. D., Leoni, C., Proli, F., Zampino, G., Gasbarrini, A., & Onesimo, R. (2022) · Nutrients · doi:10.3390/nu14081578 · Cited by 21
Practical management of functional abdominal pain in children
Brown, L. K., Beattie, R. M., & Tighe, M. P. (2015) · Archives of Disease in Childhood · doi:10.1136/archdischild-2014-306426 · Cited by 18
An Update on the Assessment and Management of Pediatric Abdominal Pain
Friesen, C. A., Colombo, J. M., Deacy, A. D., & Schurman, J. V. (2021) · Pediatric Health Medicine and Therapeutics · doi:10.2147/phmt.s287719 · Cited by 21
Treatment Interventions for the Management of Intestinal Permeability: A Cross-Sectional Survey of Complementary and Integrative Medicine Practitioners
Leech, B., Schloss, J. M., & Steel, A. (2019) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2018.0374 · Cited by 16
“85,86 AKT, protein kinase B; AMPK, adenosine monophosphate-activated protein kinase; CaMKK2, calcium/calmodulin-dependent protein kinase 2; CLOCK, circadian locomotor output cycles kaput; COX, cyclooxygenase; CXCR3, C-X-C chemokine receptor type 3; CYP2E1, cytochrome P2E1; HSF1, heat shock factor 1; IFN-g , interferon…”
Influential
Comparison of the Efficacy of Buspirone and Placebo in Childhood Functional Abdominal Pain: A Randomized Clinical Trial
Badihian, N., Yaghini, O., Badihian, S., Shahsanai, A., & Saneian, H. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000589 · Cited by 15
The Efficacy of a Mix of Probiotics (Limosilactobacillus reuteri LMG P-27481 and Lacticaseibacillus rhamnosus GG ATCC 53103) in Preventing Antibiotic-Associated Diarrhea and Clostridium difficile Infection in Hospitalized Patients: Single-Center, Open-Label, Randomized Trial
Saviano, A., Petruzziello, C., Cancro, C., Macerola, N., Petti, A., Nuzzo, E., Migneco, A., & Ojetti, V. (2024) · Microorganisms · doi:10.3390/microorganisms12010198 · Cited by 15
“It is currently indicated in the treatment and prevention of AAD, so much so, that it is also recommended by the European Society of Pediatric Gastroenterology and Nutrition (ESPGHAN) at a dosage of at least 10 9 CFU/day during the hospitalization period [42,44].”
Alternative investigations for irritable bowel syndrome
Philpott, H., Nandurkar, S., Lubel, J., & Gibson, P. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2012.07291.x · Cited by 15
Probiotics and prebiotics in pediatric diarrheal disorders
Vandenplas, Y., Greef, E. D., Hauser, B., Devreker, T., & Veereman-Wauters, G. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2013.771632 · Cited by 15
Probiotics for management of functional abdominal pain disorders in children
Gordon, M. A., Farrell, M. K., Thomas, A. G., Akobeng, A. K., & Wallace, C. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012849 · Cited by 14
Targeting the Intestinal Microbiota in the Pediatric Population
Ringel‐Kulka, T. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533612439895 · Cited by 14
Functional gastrointestinal disorders in children and adolescents: Knowledge, practice and attitudes of Australian paediatricians
Heinsch, M., & Nightingale, S. L. (2019) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.14342 · Cited by 14
Intestinal permeability in children/adolescents with functional dyspepsia
Neilan, N. A., Garg, U. C., Schurman, J. V., & Friesen, C. A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-275 · Cited by 14
Ultrasonic pre-treatment to enhance drying of potentially probiotic guava (Psidium guajava): Impact on drying kinetics, Lacticaseibacillus rhamnosus GG viability, and functional quality
Gonçalves, D. J. R., Costa, N. D. A., Paiva, M. J. D. A. E., de Oliveira, V. C., Maia, N. M. A., Magalhães, I. S., Borges, L. L. R., Stringheta, P. C., Martins, E. M. F., Vieira, É. N. R., et al. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113374 · Cited by 13
Selective method for identification and quantification ofBifidobacterium animalissubspecieslactisBB-12 (BB-12) from the gastrointestinal tract of healthy volunteers ingesting a combination probiotic of BB-12 andLactobacillus rhamnosusGG
Poutsiaka, D. D., Mahoney, I., McDermott, L. A., Stern, L. L., Thorpe, C. M., Kane, A. V., Baez-Giangreco, C., McKinney, J., Davidson, L. E., Leyva, R., et al. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13436 · Cited by 12
EFECTOS CLÍNICOS DE LOS PROBIÓTICOS: QUÉ DICE LA EVIDENCIA
Claudia Manzano, A., Diana Estupiñán, G., & Poveda, E. (2012) · Revista chilena de nutrición · doi:10.4067/s0717-75182012000100010 · Cited by 13
Intestinal immune activation in juvenile idiopathic arthritis
Arvonen, M. (2013) · Cited by 12
Probiotics and Irritable Bowel Syndrome
Korpela, R., & Niittynen, L. (2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.18573 · Cited by 13
Chronic and Recurrent Abdominal Pain
Hyman, P. E. (2016) · Pediatrics in Review · doi:10.1542/pir.2015-0169 · Cited by 12
Inflammatory Bowel Disease
Parian, A. M., Mullin, G. E., Langhorst, J., & Brown, A. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00050-5 · Cited by 15
Effects of probiotic supplementation on abdominal pain severity in pediatric patients with irritable bowel syndrome: a systematic review and meta-analysis of randomized clinical trials
Fatahi, S., Hosseini, A., Sohouli, M. H., Sayyari, A., Khatami, K., Farsani, Z. F., Amiri, H., Dara, N., de Souza, I. G. O., & Santos, H. O. (2022) · World Journal of Pediatrics · doi:10.1007/s12519-022-00516-6 · Cited by 13
Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy
Mitchell, L. K., Heussler, H., Burgess, C. J., Rehman, A., Steinert, R. E., & Davies, P. S. W. (2024) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-024-06588-9 · Cited by 13
“…have shown efficacy in improving GI symptoms and intestinal barrier function ( L. plantarum WCFS1 and L. rhamnosus GG ) (Parracho et al., 2010 ; Francavilla et al., 2010 ), shifting ASD-asso-ciated microbial metabolites ( L. plantarum WCFS1 and L. Acidophilus Rosell-11) (Parracho et al., 2010;…”
Effect of a synbiotic on functional abdominal pain in childhood.
Gholizadeh, A., Mehrabani, S., Dooki, M. E., & Ahmadi, M. H. (2021) · PubMed Central · doi:10.22088/cjim.12.2.194 · Cited by 12
Evaluation of strain-specific primers for identification ofLactobacillus rhamnosusGG
Endo, A., Aakko, J., & Salminen, S. (2012) · FEMS Microbiology Letters · doi:10.1111/1574-6968.12015 · Cited by 11
Increased Gut Permeability in First-degree Relatives of Children with Irritable Bowel Syndrome or Functional Abdominal Pain
McOmber, M. E., Rafati, D. S., Cain, K. C., Devaraj, S., Weidler, E. M., Heitkemper, M. M., & Shulman, R. J. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.05.011 · Cited by 14
Definitions of Pediatric Functional Abdominal Pain Disorders and Outcome Measures: A Systematic Review
Zeevenhooven, J., Timp, M. L., Singendonk, M. M. J., Benninga, M. A., & Tabbers, M. M. (2019) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2019.04.048 · Cited by 11
Gut–Brain Axis, Microbiota and Probiotics—Current Knowledge on Their Role in Irritable Bowel Syndrome: A Review
Mărginean, C. M., Popescu, M., Drocaș, A. I., Cazacu, S. M., Mitruţ, R., Mărginean, I. C., Iacob, G. A., Popescu, M. S., Docea, A. O., & Mitruț, P. (2023) · Gastrointestinal Disorders · doi:10.3390/gidisord5040043 · Cited by 10
“One of the most exhaustive meta-analyses on the role of prebiotics in IBS therapy, published in 2019 by Bridgette Wilson et al. [123], concluded that prebiotics did not improve gastrointestinal symptoms, outcome, or quality of life in patients with IBS, but increased faecal Biﬁdobacteria .”
How to manage irritable bowel syndrome in children
Levy, E. I., Geyter, C. D., Chaib, A. O., Aman, B. A., Hegar, B., & Vandenplas, Y. (2021) · Acta Paediatrica · doi:10.1111/apa.16107 · Cited by 10
Functional response to a microbial synbiotic in the gastrointestinal system of children: a randomized clinical trial
Tierney, B. T., Versalovic, J. A., Fasano, A., Petrosino, J. F., Chumpitazi, B. P., Mayer, E. A., Boetes, J., Smits, G., Parkar, S. G., Voreades, N., et al. (2022) · Pediatric Research · doi:10.1038/s41390-022-02289-0 · Cited by 10
Dietary interventions for pediatric patients with functional abdominal pain disorders: a systematic review and network meta-analysis
Hua, C., Chen, Y., Tao, Q., Shi, Y., Li, L., Xie, C.-R., Chen, M., Zhou, Z.-L., & Zheng, H. (2023) · European Journal of Pediatrics · doi:10.1007/s00431-023-04979-1 · Cited by 10
Cognitive-behavioural therapy for children with irritable bowel syndrome
Buffone, A., & Goldman, R. D. (2021) · Canadian Family Physician · doi:10.46747/cfp.6712905 · Cited by 11
Lacticaseibacillus rhamnosus GG -driven remodeling of arginine metabolism mitigates gut barrier dysfunction
Antonio, J. M., Liu, Y., Suntornsaratoon, P., Jones, A., Ambat, J., Bala, A., Kanattu, J., Flores, J., Bandyopadhyay, S., Upadhyay, R., et al. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00366.2024 · Cited by 8
Probiotics and gastrointestinal diseases
Dargenio, V. N., Castellaneta, S. P., PANICO, S., Papagni, M. E., Dargenio, C., SCHETTINI, F., Francavilla, R., & Cristofori, F. (2022) · Minerva Pediatrics · doi:10.23736/s2724-5276.22.07031-8 · Cited by 10
Self-citation
Irritable Bowel Syndrome
Mokha, J. S., & Hyams, J. S. (2016) · Springer eBooks · doi:10.1007/978-3-319-43268-7_37 · Cited by 9
Probiotics: an update
Vandenplas, Y., Huys, G. R. B., & Daube, G. (2015) · Jornal de Pediatria (Versão em Português) · doi:10.1016/j.jpedp.2014.08.006 · Cited by 9
Probiotic formulations and gastro-intestinal diseases in the paediatric population: a narrative review
Siddiqui, A., Haider, R., Aaqil, S. I., Vohra, L. I., Qamar, K., Jawed, A., Fatima, N., Adnan, A., Parikh, V., Ochani, S., et al. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002007 · Cited by 9
Gut permeability is affected by sex and increased in children with irritable bowel syndrome but not in functional abdominal pain
Shulman, R. J., Devaraj, S., & Heitkemper, M. M. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13765 · Cited by 8
Exploring the Potential Use of Probiotics, Prebiotics, Synbiotics, and Postbiotics as Adjuvants for Modulating the Vaginal Microbiome: a Bibliometric Review
Xavier-Santos, D., Bedani, R., Vieira, I. D. A., Padilha, M., Lima, C. M. G., Silva, J. D. R., Ferreira, B. M., Giraldo, P. C., Pagnossa, J. P., Sivieri, K., et al. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10444-8 · Cited by 10
Decoding Abdominal Pain in Constipation-predominant Irritable Bowel Syndrome and Functional Constipation: Mechanisms and Managements
Luo, J., Xu, Q., Xu, S., Zhai, L., Yuan, C., & Bian, Z. (2025) · Current Gastroenterology Reports · doi:10.1007/s11894-025-00967-7 · Cited by 8
Probiotics in Functional Gastrointestinal Disorders
Hojsak, I. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-58572-2_10 · Cited by 9
The effects of a 6-week intervention with Limosilactobacillus reuteri ATCC PTA 6475 alone and in combination with L. reuteri DSM 17938 on gut barrier function, immune markers, and symptoms in patients with IBS-D—An exploratory RCT
König, J., Rubio, M., Forsgård, R. A., Rode, J., Axelsson, J., Grompone, G., & Brummer, R. J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0312464 · Cited by 7
Irritable bowel syndrome: the problem and the problem of treating it – is there a role for probiotics?
Santos, A. R., & Whorwell, P. J. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114000706 · Cited by 8
Lactic Acid Bacteria and the Human Gastrointestinal Tract
Kwok, L. (2014) · Springer eBooks · doi:10.1007/978-94-017-8841-0_6 · Cited by 7
Irritable bowel syndrome in children: the placebo response rate and influencing factors a meta-analysis
Cai, L., Li, X., Cai, Q.-H., Guo, S.-X., Zhang, Y., Sun, W.-C., Zhao, Z.-H., & Hu, S. (2024) · Pediatric Research · doi:10.1038/s41390-023-02996-2 · Cited by 6
“In terms of outcome indicators, it is also important to focus on stool trait changes in addition to abdominal pain symptoms.”
[Clinical applications of the use of probiotics in pediatrics].
Álvarez-Calatayud, G., Pérez-Moreno, J., Tolín, M., & Sánchez, C. (2013) · PubMed · doi:10.3305/nh.2013.28.3.6603 · Cited by 6
Approach to a Child with Functional Abdominal Pain
Sood, M. R., & Matta, S. R. (2016) · The Indian Journal of Pediatrics · doi:10.1007/s12098-016-2111-5 · Cited by 6
“Another study compared 8-wk Lactobacillus rhamnosus GG therapy in 141 children with irritable bowel syndrome and FAPwith placebo [40].”
Background
Antimicrobial Effects of Probiotics and Novel Probiotic-Based Approaches for Infectious Diseases
Li, P., & Gu, Q. (2018) · InTech eBooks · doi:10.5772/intechopen.72804 · Cited by 7
“Probiotics have been shown to improve barrier function and the mechanisms of barrier function including alteration of tight junction protein expression and/or localization, induction of mucus secretion, increased production of cytoprotective molecules such as heat-shock proteins, inhibition of apoptosis of epithelial…”
Background
Preventing and Treating Colic: An Update
Indrio, F., & Dargenio, V. N. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-58572-2_4 · Cited by 5
Self-citation
Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome
Maslennikov, R. V., Gosteeva, E., Ananeva, V., Korshunova, L., Kravtsowa, A., Poluektova, E., Ulyanin, A. I., Sigidaev, A. S., Kikhasurova, P. M., & Ivashkin, V. T. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15031152 · Cited by 11
Gut microbiome pattern in adolescents with functional gastrointestinal disease
Nafarin, A. R., Hegar, B., Sjakti, H. A., & Vandenplas, Y. (2019) · International Journal of Pediatrics and Adolescent Medicine · doi:10.1016/j.ijpam.2019.01.005 · Cited by 5
Chronic Pain
Baker, R. D., Szabova, A., & Goldschneider, K. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-42974-0.00045-8 · Cited by 6
Ability of polymicrobial probiotic and mono-strain probiotic to reduce functional abdominal pain in children: a randomized clinical trial
Jafari, S. S., Hashemi, M., Sadeghi, B., & Almasi‐Hashiani, A. (2022) · Korean Journal of Pediatrics · doi:10.3345/cep.2022.00339 · Cited by 5
Current Issues in the Management of Pediatric Functional Abdominal Pain
Romano, C., & Porcaro, F. (2014) · Reviews on Recent Clinical Trials · doi:10.2174/1574887109666140423124521 · Cited by 5
Lactobacillus probiotics for treating functional dyspepsia in children
Ahyani, T., Supriatmo, S., Deliana, M., Yudiyanto, A. R., & Sinuhaji, A. B. (2016) · Paediatrica Indonesiana · doi:10.14238/pi56.1.2016.07 · Cited by 5
Chinese herbal medicine versus probiotics for irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials
Bu, F.-L., Chen, R., Lin, Z., Cao, H., Robinson, N., Liang, N., & Liu, J. (2020) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2020.101177 · Cited by 5
Probiotics in pediatrics
Depoorter, L., & Vandenplas, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85170-1.00014-2 · Cited by 5
Probiotics for Otolaryngologic Disorders
Czibulka, A. (2022) · Otolaryngologic Clinics of North America · doi:10.1016/j.otc.2022.06.003 · Cited by 5
Screening of probiotic strains to improve visceral hypersensitivity in irritable bowel syndrome by using in vitro and in vivo approaches
Torres-Maravilla, E., Carvalho, F. A., Holowacz, S., Delannoy, J., Lenoir, L., Jacouton, E., Barbut, F., Langella, P., Bermúdez‐Humarán, L. G., & Waligora‐Dupriet, A. (2024) · Beneficial Microbes · doi:10.1163/18762891-bja00006 · Cited by 5
The Potential for use of Probiotics in Pediatric Irritable Bowel Syndrome and Inflammatory Bowel Disease
Guandalini, S. (2014) · Current Pediatrics Reports · doi:10.1007/s40124-014-0050-z · Cited by 4
Effectiveness Of Probiotics In Irritable Bowel Syndrome: A Systematic Review With Meta-Analysis
Nikfar, S., Mozafari, S., Didari, T., & Abdollahi, M. R. (2014) · Value in Health · doi:10.1016/j.jval.2014.08.799 · Cited by 3
Lactobacillus rhamnosus GGreduces frequency and severity of abdominal pain compared with placebo in children with irritable bowel syndrome
Rose, M. A. (2011) · BMJ Evidence-Based Medicine · doi:10.1136/ebm1199 · Cited by 4
Irritable Bowel Syndrome
Zeisler, B., & Hyams, J. S. (2012) · Humana Press eBooks · doi:10.1007/978-1-60761-709-9_34 · Cited by 4
A Randomized Controlled Trial of Lactobacillus GG in Children With Functional Abdominal Pain
Talley, N. J. (2011) · Yearbook of Gastroenterology · doi:10.1016/j.ygas.2011.08.010 · Cited by 3
Probiotics for the treatment of irritable bowel syndrome in children
Barajas-Nava, L. A., Sánchez, A. C., Castilla-Peón, M. F., Pizarro-Castellanos, M., & Vázquez-Frías, R. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013095 · Cited by 3
LGGTM- A promising therapy in gastro-intestinal infections
Maladkar, M. N., Yadav, A., & Save, N. (2020) · Indian Journal of Microbiology Research · doi:10.18231/j.ijmr.2020.055 · Cited by 4
Scientific Evidence for the Treatment of Children with Irritable Bowel Syndrome
Quitadamo, P., Isoldi, S., Mallardo, S., Zenzeri, L., & Nardo, G. D. (2021) · Current Pediatric Reviews · doi:10.2174/1573396317666210127123330 · Cited by 4
Intestinal permeability in children with recurrent respiratory and gastrointestinal symptoms
Barreto, M., Evangelisti, M., Principessa, L., Simmaco, M., Negro, V., Lionetto, L., Campisano, M., & Villa, M. P. (2015) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.12927 · Cited by 3
The Cochrane Library and the Treatment of Chronic Abdominal Pain in Children and Adolescents: An Overview of Reviews
Foisy, M., Ali, S., Geist, R., Weinstein, M., Michail, S. K., & Thakkar, K. H. (2011) · Evidence-Based Child Health A Cochrane Review Journal · doi:10.1002/ebch.818 · Cited by 3
Pharmacotherapy of Functional Disorders in Children
Probst, L. A., & Burgess, J. L. (2014) · Springer eBooks · doi:10.1007/978-1-4899-8074-8_26 · Cited by 3
Review of probiotics in children
Waikar, Y. (2013) · doi:10.1016/j.pid.2013.01.002 · Cited by 3
Probiotics: An Update to Past Researches
Shirazinia, R., Golabchifar, A. A., Mishkar, A. P., & Fazeli, M. R. (2020) · International journal of basic science in medicine · doi:10.34172/ijbsm.2020.14 · Cited by 2
Effect of pro- and metabiotic Lactobacillus delbrueckii D5 strain on myocardial resistance to ischemia – reperfusion injury in the rat model of systemic inflammatory response
Borshchev, Y. Y., Minasyan, S. M., Semenova, N. Y., Burovenko, I. Y., Borshchev, Y. Y., Gritsenko, E. Y., Sheptitsky, V. A., Suvorov, A. N., & Galagudza, M. M. (2024) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2024-2-28-36 · Cited by 2
Treatment of Chronic Atopy and Irritable Bowel Syndrome in a 7-year-old: A Case Report.
O’Neil-Smith, K., & Barber, M. S. (2017) · Europe PMC (PubMed Central) · Cited by 2
Functional Gastrointestinal Disorders in Children
Indrio, F., & Riezzo, G. (2013) · World review of nutrition and dietetics · doi:10.1159/000345737 · Cited by 2
Self-citation
Chapter 17 Safety of probiotics in infants and children
van den Nieuwboer, M., Browne, P. D., & Claassen, E. (2017) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-839-1_17 · Cited by 2
Chronische Bauchschmerzen
Berger, T., & Rohr, U. (2015) · Springer eBooks · doi:10.1007/978-3-662-45057-4_15 · Cited by 2
Probiotics and Prebiotics in Pediatric Diarrheal Disorders
Vandenplas, Y., Hauser, B., Greef, E. D., Devreker, T., & Veereman-Wauters, G. (2013) · CRC Press eBooks · doi:10.1201/b15561-15 · Cited by 2
Pharmacological interventions for pediatric irritable bowel syndrome
Pesce, M., Puoti, M. G., Rybak, A., Andreozzi, M., Bruzzese, E., Sarnelli, G., & Borrelli, O. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1976753 · Cited by 3
An Overview of Probiotic Research
Ζουμποπούλου, Γ., Tsakalidou, E., & Thomas, L. V. (2017) · Wiley eBooks · doi:10.1002/9781119214137.ch8 · Cited by 3
Infant Colic Crying and Gastrointestinal Tract – Causes, Consequences and Cure
Pärtty, A. (2014) · UTUPub (University of Turku) · Cited by 2
Current and novel therapeutic strategies in pediatric irritable bowel syndrome and functional abdominal pain-not otherwise specified
Vermeijden, N. K., Oorthuys, A. O. J., Groen, J., Thapar, N., Vlieger, A. M., Puoti, M. G., Borrelli, O., & Benninga, M. A. (2025) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2025.2582017 · Cited by 1
“These results were sustained during the four-week follow-up [51].”
Probiotic modulation of central and peripheral sensitization in a migraine model via the gut–brain–trigeminal axis
Suthivanich, P., Vongseenin, S., Auvichayapat, V., Supronsinchai, W., Tumwasorn, S., Chayanupatkul, M., & Bongsebandhu‐phubhakdi, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-24928-2 · Cited by 1
Treatment of pediatric abdominal pain: what is the evidence?
Saps, M., & Arrizabalo, S. (2025) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2025.2592089 · Cited by 1
“Among them, Lactobacillus rhamnosus GG received a conditional recommendation for IBS based on two studies, supported by moderate certainty for reducing pain frequency [10,11].”
Irritable Bowel Syndrome: A Review of Management Strategies
Lebowitz, J., Barash, L., & Perez, M. E. (2026) · Current Treatment Options in Pediatrics · doi:10.1007/s40746-026-00366-8 · Cited by 2
“Two RCTs showed significant reduction in frequency and severity of abdominal pain with lactoba-cillus rhamnosus compared to placebo in pediatric patients with functional abdominal pain [35, 36].”
Comparative efficacy of probiotic, prebiotic, and synbiotic interventions in children with functional abdominal pain disorders: a systematic review and network meta-analysis
Yang, Y., Li, Y., Yan, X., Huang, W., Cao, C., Yan, H., & Leng, L. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1764837 · Cited by 2
Viable and Heat-Inactivated Bifidobacterium bifidum MIMBb75 Protect the Intestinal Barrier
Storr, M., & Gschwender, M. (2026) · Microorganisms · doi:10.3390/microorganisms14061349 · Cited by 1
Functional Abdominal Pain
Sood, M. R., & Sood, M. R. (2012) · Humana Press eBooks · doi:10.1007/978-1-60761-709-9_35 · Cited by 1
Early Nutrition and its Effect on the Development of Functional GI Disorders
Vandenplas, Y., & Huysentruyt, K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100168-4.00014-8 · Cited by 1
Management of irritable bowel syndrome in children
Malagelada, J. (2018) · Journal of Pediatrics and Pediatric Medicine · doi:10.29245/2578-2940/2018/3.1127 · Cited by 1
Prescribing Probiotics
Takahashi, J., & Rindfleisch, J. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00105-5 · Cited by 2
Functional Abdominal Pain
Sood, M. R., & Kovacic, K. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-43268-7_38 · Cited by 1
Recurring Abdominal Pain in Pediatrics
Weydert, J. A. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1793-8.00097-2 · Cited by 1
Effect of probiotics therapy on intestinal leakage: A meta-analysis of randomized controlled trials
Li, C.-P., Kuo, W., Chang, K.-S., Yu, J.-T., & Tsai, R. (2023) · 童綜合醫學雜誌 · doi:10.4103/etmj.tmj-110012 · Cited by 1
Pharmacological Management for Pediatric Irritable Bowel Syndrome: A Review
Alyasi, A. S., Altawili, M. A., AlAbbadi, A., Hamdi, A. H. A., Alshammery, A., Alfahad, M. I., Alamri, R. M., Alanazi, T. H., Harbi, M. H. A., Alajmi, A. M., et al. (2023) · Cureus · doi:10.7759/cureus.49197 · Cited by 1
“From these data, LGG is effective in reducing the severity of pain in IBS patients [29].”
Method
Lactobacillus rhamnosus for treating irritable bowel syndrome in children – a systematic review with meta-analysis
Tarnoruda, J., Ruszczyński, M., Żółkiewicz, J., Sulej, L., Bożek, B., & Hoffmann, A. (2024) · Pediatria Polska · doi:10.5114/polp.2024.136009 · Cited by 1
The interdisciplinary management of pediatric pain: Time for more integration
Weydert, J. A. (2013) · Techniques in Regional Anesthesia and Pain Management · doi:10.1053/j.trap.2014.07.006 · Cited by 1

Authors: Francavilla, R., Miniello, V., Magistà, A. M., De Canio, A., Bucci, N., Gagliardi, F., Lionetti, E., Castellaneta, S., Polimeno, L., Peccarisi, L., Indrio, F., & Cavallo, L.
Affiliations: Departments of Developmental Biomedicine and
University of Catania (IT)
Ospedale San Paolo (IT)
University of Bari Aldo Moro (IT)
ASL-Bari, Bari, Italy
Corresponding author: Francavilla, Ruggiero
ORCID: Francavilla, Ruggiero
Miniello, Vito
Lionetti, Elena
Castellaneta, Stefania
Polimeno, Lorenzo
Indrio, Flavia
Cavallo, Luciano
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 2010-12-01
Volume: 126
Issue: 6
Pages: e1445-e1452
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2010-0467
OpenAlex: W2146310450
Cited by: 242
References: 46
Citations by year: 2026: 6 · 2025: 9 · 2024: 16 · 2023: 10 · 2022: 18 · 2021: 18 · 2020: 13 · 2019: 13 · 2018: 21 · 2017: 18 · 2016: 18 · 2015: 17 · 2014: 20 · 2013: 15 · 2012: 17
FWCI: 14.50
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
AIRUS (submittedVersion)
Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: Lactobacillus rhamnosus GG, probiotics, functional abdominal pain, irritable bowel syndrome, children, intestinal permeability, intestinal barrier
MeSH terms: Adolescent, Child, Child, Preschool, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Abdominal Pain, Treatment Outcome, Probiotics, Irritable Bowel Syndrome, Lacticaseibacillus rhamnosus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Randomized Controlled Trial of Lactobacillus GG in Children With Functional Abdominal Pain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks