Cited by 242Gastrointestinal motility and disordersProbiotics and Fermented FoodsGut microbiota and health

The DOI matches its Crossref record; 44 of the 46 references it cites were found in a registry or an index.

A Randomized Controlled Trial of Lactobacillus GG in Children With Functional Abdominal Pain

Francavilla, Ruggiero, Miniello, Vito, Magistà, Anna Maria, De Canio, Angela, Bucci, Nunzia, Gagliardi, Francesca, Lionetti, Elena, Castellaneta, Stefania, Polimeno, Lorenzo, Peccarisi, Lucia, Indrio, Flavia, Cavallo, Luciano·2010·Pediatrics

DOI 10.1542/peds.2010-0467

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Abstract

OBJECTIVE: Our aim was to determine whether Lactobacillus rhamnosus GG (LGG) relieves symptoms in children with recurrent abdominal pain. PATIENTS AND METHODS: A total of 141 children with irritable bowel syndrome (IBS) or functional pain were enrolled in 9 primary care sites and a referral center. Children entered a randomized, double-blind, placebo-controlled trial and received LGG or placebo for 8 weeks and entered follow-up for 8 weeks. The primary outcome was overall pain at the end of the intervention period. At entry and at the end of the trial, children underwent a double-sugar intestinal permeability test. RESULTS: Compared with baseline, LGG, but not placebo, caused a significant reduction of both frequency (P < .01) and severity (P < .01) of abdominal pain. These differences still were significant at the end of follow-up (P < .02 and P < .001, respectively). At week 12, treatment success was achieved in 48 children in the LGG group compared with 37 children in the placebo group (P < .03); this difference still was present at the end of follow-up (P < .03). At entry, 59% of the children had abnormal results from the intestinal permeability test; LGG, but not placebo, determined a significant decrease in the number of patients with abnormal results from the intestinal permeability testing (P < .03). These effects mainly were in children with IBS. CONCLUSIONS: LGG significantly reduces the frequency and severity of abdominal pain in children with IBS; this effect is sustained and may be secondary to improvement of the gut barrier.

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Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood
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Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood
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Authors: Francavilla, R., Miniello, V., Magistà, A. M., De Canio, A., Bucci, N., Gagliardi, F., Lionetti, E., Castellaneta, S., Polimeno, L., Peccarisi, L., Indrio, F., & Cavallo, L.
Affiliations: Departments of Developmental Biomedicine and
University of Catania (IT)
Ospedale San Paolo (IT)
University of Bari Aldo Moro (IT)
ASL-Bari, Bari, Italy
Corresponding author: Francavilla, Ruggiero
ORCID: Francavilla, Ruggiero
Miniello, Vito
Lionetti, Elena
Castellaneta, Stefania
Polimeno, Lorenzo
Indrio, Flavia
Cavallo, Luciano
Venue: Pediatrics
Publisher: American Academy of Pediatrics (AAP)
Published: 2010-12-01
Volume: 126
Issue: 6
Pages: e1445-e1452
ISSN: 0031-4005 (ISSN-L)
1098-4275
DOI: 10.1542/peds.2010-0467
OpenAlex: W2146310450
Cited by: 242
References: 46
Citations by year: 2026: 6 · 2025: 9 · 2024: 16 · 2023: 10 · 2022: 18 · 2021: 18 · 2020: 13 · 2019: 13 · 2018: 21 · 2017: 18 · 2016: 18 · 2015: 17 · 2014: 20 · 2013: 15 · 2012: 17
FWCI: 14.50
Type: journal article
Language: en
Open access: closed
Locations: PEDIATRICS (publishedVersion)
PubMed (publishedVersion)
AIRUS (submittedVersion)
Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: Lactobacillus rhamnosus GG, probiotics, functional abdominal pain, irritable bowel syndrome, children, intestinal permeability, intestinal barrier
MeSH terms: Adolescent, Child, Child, Preschool, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Abdominal Pain, Treatment Outcome, Probiotics, Irritable Bowel Syndrome, Lacticaseibacillus rhamnosus

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A Randomized Controlled Trial of Lactobacillus GG in Children With Functional Abdominal Pain

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