The DOI matches its Crossref record; 44 of the 46 references it cites were found in a registry or an index.
A Randomized Controlled Trial of Lactobacillus GG in Children With Functional Abdominal Pain
Abstract
OBJECTIVE: Our aim was to determine whether Lactobacillus rhamnosus GG (LGG) relieves symptoms in children with recurrent abdominal pain. PATIENTS AND METHODS: A total of 141 children with irritable bowel syndrome (IBS) or functional pain were enrolled in 9 primary care sites and a referral center. Children entered a randomized, double-blind, placebo-controlled trial and received LGG or placebo for 8 weeks and entered follow-up for 8 weeks. The primary outcome was overall pain at the end of the intervention period. At entry and at the end of the trial, children underwent a double-sugar intestinal permeability test. RESULTS: Compared with baseline, LGG, but not placebo, caused a significant reduction of both frequency (P < .01) and severity (P < .01) of abdominal pain. These differences still were significant at the end of follow-up (P < .02 and P < .001, respectively). At week 12, treatment success was achieved in 48 children in the LGG group compared with 37 children in the placebo group (P < .03); this difference still was present at the end of follow-up (P < .03). At entry, 59% of the children had abnormal results from the intestinal permeability test; LGG, but not placebo, determined a significant decrease in the number of patients with abnormal results from the intestinal permeability testing (P < .03). These effects mainly were in children with IBS. CONCLUSIONS: LGG significantly reduces the frequency and severity of abdominal pain in children with IBS; this effect is sustained and may be secondary to improvement of the gut barrier.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and in humans [161,175]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [161]
Citations
Cites
3 retracted
Huertas‐Ceballos, A., Logan, S., Bennett, C., & Macarthur, C. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003017.pub2 · Cited by 210
RetractedHuertas‐Ceballos, A., Logan, S., Bennett, C., Macarthur, C., & Martin, A. E. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003019.pub4 · Cited by 109
RetractedHuertas‐Ceballos, A., Logan, S., Bennett, C., & Macarthur, C. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003019.pub2 · Cited by 49
RetractedChildhood Functional Gastrointestinal Disorders: Child/Adolescent
Rasquin, A., Lorenzo, C. D., Forbes, D., Guiraldes, E., Hyams, J. S., Staiano, A., & Walker, L. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.063 · Cited by 1,804
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
Probiotic bacteria enhance murine and human intestinal epithelial barrier function
Madsen, K., Cornish, A. S., Soper, P., McKaigney, C. J., Jijon, H. B., Yachimec, C., Doyle, J. S. G., Jewell, L. D., & Simone, C. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.27224 · Cited by 1,096
Kassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002
Childhood functional gastrointestinal disorders
Weber, A. M., Hyman, P. E., Cucchiara, S., Fleisher, D. R., Hyams, J. S., Milla, P. J., & Staiano, A. (1999) · Gut · doi:10.1136/gut.45.2008.ii60 · Cited by 815
Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793
A new analogue scale for assessing children's pain: an initial validation study
McGrath, P. A., Seifert, C. E., Speechley, K. N., Booth, J. C., Stitt, L., & Gibson, M. C. (1996) · Pain · doi:10.1016/0304-3959(95)00171-9 · Cited by 558
Cited by
Sorted by citations
Items 201–242 of 242
Hospido, N. F., Cardelle‐Cobas, A., López, P. R., Sáez, A. C., & Sampayo, C. F. (2017) · Farmacéuticos Comunitarios · doi:10.5672/fc.2173-9218.(2017/vol9).001.03 · Cited by 2
Management of abdominal pain in pediatric emergency departments
Ryoo, E. (2018) · Pediatric Emergency Medicine Journal · doi:10.22470/pemj.2018.00311 · Cited by 1
Probiotics and Herbal Therapies
Czibulka, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-12318-5_8 · Cited by 1
Recurring Abdominal Pain in Pediatrics
Weydert, J. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00045-1 · Cited by 1
Early nutrition and its effect on the development of functional gastrointestinal disorders
Salvatore, S., & Vandenplas, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824389-3.00006-4 · Cited by 1
Czibulka, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-12998-8_23 · Cited by 1
Probiotic Formulations & Gastro-Intestinal Diseases: A State-of-Art ReviewPreprint
Siddiqui, A., Haider, R., Aaqil, S. I., Vohra, L. I., Qamar, K., Fatima, N., Adnan, A., & Parikh, V. (2022) · Preprints.org · doi:10.20944/preprints202211.0328.v1
Dietary fat and bile acids in the pathogenesis of gut barrier dysfunction
Stenman, L. K. (2013) · Työväentutkimus Vuosikirja
Proceedings from the FFF Probiotics 2012 meeting in Turku, Finland, 11–13 June 2012
(2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.18868
A psychosocial perspective on pediatric functional abdominal pain: risk factors and treatment
van der Veek, S. (2012) · UvA-DARE (University of Amsterdam)
Manzano, A., Estupiñán, G. D., & Poveda, E. (2012)
Robles, V., Guarner, F., Soriano, G., Sánchez, E., & Guarner, C. (2013)
Functional Abdominal Pain and Other Functional Gastrointestinal Disorders
Tighe, M. P., & Beattie, R. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-17169-2_19
Are Probiotics a Panacea for Gastrointestinal Complaints
Bauchner, H. (2011) · Journal watch · doi:10.1056/pa201101050000006
Treatment of Functional Bowel Disorders With Prebiotics and Probiotics
Hod, K., & Ringel, Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804024-9.00038-0
Naturheilkundliche Strategien beim RDS
Dobos, G. (2017) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-017-9878-9
The role of probiotics in the correction of the gastrointestinal disorders in children
Александровна, Х. Д., Чухляев, П. В., & Ruzhentsova, T. A. (2021) · Лечащий врач · doi:10.51793/os.2021.24.6.005
McFarland, L. V., Karatas, T., & Karataş, A. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3894914
Effects of a thermal reservoir on variational functions in open systems (18 pages)
Stenholm, S., & Jakob, M. (2004) · Physical Review A
Probiotics in the prevention and management of irritable bowel syndrome
Levy, E. I., Geyter, C. D., Hauser, B., & Vandenplas, Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00028-3
Vandenplas, Y., Huys, G. R. B., & Daube, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-17169-2_45
Rosen, J. M., & Saps, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-43268-7_36
Functional response to a microbial synbiotic in the gastrointestinal system of constipated childrenPreprint
Tierney, B. T., Versalovic, J. A., Fasano, A., Petrosino, J. F., Chumpitazi, B. P., Mayer, E. A., Boetes, J., Smits, G., Parkar, S. G., Voreades, N., et al. (2022) · medRxiv · doi:10.1101/2022.04.07.22273329
Thérapie cognitivo-comportementale pour les enfants atteints du syndrome du côlon irritable
Buffone, A., & Goldman, R. D. (2021) · Canadian Family Physician · doi:10.46747/cfp.6712e323
Hospido, N. F., Cardelle‐Cobas, A., López, P. R., Sáez, A. C., & Sampayo, C. F. (2017) · Farmacéuticos Comunitarios · doi:10.5672/fc.2173-9218.(2017/vol1).001.03
Schurman, J. V., Deacy, A. D., & Friesen, C. A. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780198818762.003.0030
Therapieansätze bei funktionellen gastrointestinalen Störungen
Bolten, M. I., & Légeret, C. (2022) · Springer eBooks · doi:10.1007/978-3-662-64253-5_7
Çocuklarda Profilaktik ve Terapötik Probiyotik Kullanımı
Önata, E. T., & Özdemır, Ö. (2024) · JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH · doi:10.34084/bshr.1465778
The Various Healthcare Applications of the Genus Lactobacillus
Narasimha, S. V., Zackria, R., Chadha, R., Gheriani, A. G., Johnson, L., Pattison, R., Kim, A., Chen, G., Ryan, J., & Shih, D. Q. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.115299
Modern Experience in Pharmacotherapy of Irritable Bowel Syndrome in Children
Хавкин, А. И., Михайлович, Н. К., Veremenko, A. S., Дмитриевна, Л. И., Platonova, P. Y., Novikova, M. F., Tumas, A. S., Евгеньевна, В. Е., Lukichev, D. A., Sergeev, D. A., et al. (2025) · Педиатрическая фармакология · doi:10.15690/pf.v21i6.2841
Ettinger, G. (2014) · Scholarship@Western (Western University)
Claßen, M. (2011) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-011-2491-6
“In 2 prospektiven Studien konnte in der Reizdarmuntergruppe eine Wirkung auf Schmerzen belegt werden [18, 19].”
BackgroundProbiotics in pediatric functional abdominal pain disorders: a systematic review and meta-analysis
Balasan, N., Kharrat, F., Lega, S., Leo, G. D., D’Adamo, P., Comar, M., Barbi, E., & Zupin, L. (2026) · European Journal of Pediatrics · doi:10.1007/s00431-026-07161-5
Puoti, M. G., Oorthuys, A. O. J., Vermeijden, N. K., Benninga, M. A., & Borrelli, O. (2026) · Drugs · doi:10.1007/s40265-026-02376-0
“Another study included 141 children (aged 5–14 years) with different IBS subtypes or FAP and found that 8 weeks of LGG treatment resulted in greater reductions in both pain intensity and pain frequency, with these improvements maintained during a 4-week follow-up period [42].”
Metadata
- Authors
- Francavilla, R., Miniello, V., Magistà, A. M., De Canio, A., Bucci, N., Gagliardi, F., Lionetti, E., Castellaneta, S., Polimeno, L., Peccarisi, L., Indrio, F., & Cavallo, L.
- Affiliations
- Departments of Developmental Biomedicine and
- University of Catania (IT)
- Ospedale San Paolo (IT)
- University of Bari Aldo Moro (IT)
- ASL-Bari, Bari, Italy
- Corresponding author
- Francavilla, Ruggiero
- ORCID
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2010-12-01
- Volume
- 126
- Issue
- 6
- Pages
- e1445-e1452
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2146310450
- Cited by
- 242
- References
- 46
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 16 · 2023: 10 · 2022: 18 · 2021: 18 · 2020: 13 · 2019: 13 · 2018: 21 · 2017: 18 · 2016: 18 · 2015: 17 · 2014: 20 · 2013: 15 · 2012: 17
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- AIRUS (submittedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus rhamnosus GG, probiotics, functional abdominal pain, irritable bowel syndrome, children, intestinal permeability, intestinal barrier
- MeSH terms
- Adolescent, Child, Child, Preschool, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Abdominal Pain, Treatment Outcome, Probiotics, Irritable Bowel Syndrome, Lacticaseibacillus rhamnosus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
