The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Pharmacologic Treatment of Severe Irritability and Problem Behaviors in Autism: A Systematic Review and Meta-analysis
Abstract
BACKGROUND: Autism spectrum disorder (ASD) is increasingly recognized as a public health issue. Irritability and aggression (IA) often negatively affect the lives of people with ASD and their families. Although many medications have been tested for IA in ASDs in randomized controlled trials (RCTs), critical quantitative analyses of these trials are lacking in the literature. OBJECTIVES: To systematically review and quantitatively analyze the efficacy and safety of pharmacologic treatments for IA in youth with ASD. DATA SOURCES: Studies were identified from Medline, PsycINFO, Embase, and review articles. METHODS: Original articles on placebo-controlled RCTs of pharmacologic treatments of IA in youth age 2 to 17 years with ASD were included. Data items included study design, study goals, details of study participants, details of intervention, study results, statistical methods, side effects, and risks of bias. The primary study outcome measure was the effect size of reduction in the Aberrant Behavioral Checklist–Irritability (ABC-I) scores in the medication group, as compared with placebo, in RCTs using parallel groups design. RESULTS: Forty-six RCTs were identified. Compared with placebo, 3 compounds resulted in significant improvement in ABC-I at the end of treatment. Risperidone and aripiprazole were found to be the most effective, with the largest effect sizes. Sedation, extrapyramidal sides effects, and weight gain were assessed quantitatively. CONCLUSIONS: Although risperidone and aripiprazole have the strongest evidence in reducing ABC-I in youth with ASD, a few other compounds also showed significant efficacy with fewer potential side effects and adverse reactions in single studies.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“one meta-analysis on pharmacological treatment of irritability and problem behaviors in ASD did report that the number of subjects needed to treat was lower for risperidone [138].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [138]
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305
GRADE guidelines: 3. Rating the quality of evidence
Balshem, H., Helfand, M., Schünemann, H. J., Oxman, A. D., Kunz, R., Brozek, J., Vist, G. E., Falck-Ytter, Y., Meerpohl, J., & Norris, S. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.015 · Cited by 8,285
Dysfunction in the neural circuitry of emotion regulation–a possible prelude to violence
Davidson, R. J., Putnam, K. M., & Larson, C. L. (2000) · Science · doi:10.1126/science.289.5479.591 · Cited by 1,894
Risperidone in Children with Autism and Serious Behavioral Problems
McCracken, J. T., McGough, J., Shah, B., Cronin, P., Hong, D., Aman, M. G., Arnold, L. E., Lindsay, R., Nash, P., Hollway, J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013171 · Cited by 1,574
Correll, C. U. (2009) · JAMA · doi:10.1001/jama.2009.1549 · Cited by 1,050
Neurobiology of Aggression and Violence
Siever, L. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07111774 · Cited by 984
Emotion-Related Regulation: Sharpening the Definition
Eisenberg, N., & Spinrad, T. L. (2004) · Child Development · doi:10.1111/j.1467-8624.2004.00674.x · Cited by 915
Research works printed but not linked: 1
- Vorvick, 2009, Irritability
Cited by
Sorted by citations
Lord, C., Elsabbagh, M., Baird, G., & Veenstra-Vanderweele, J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31129-2 · Cited by 2,819
Self-citationIdentification, Evaluation, and Management of Children With Autism Spectrum Disorder
Hyman, S. L., Levy, S. E., Myers, S. M., COUNCIL ON CHILDREN WITH DISABILITIES, S. O. D. A. B. P., Kuo, D. Z., Apkon, S., Davidson, L. F., Ellerbeck, K. A., Foster, J. E. A., Noritz, G. H., et al. (2020) · Pediatrics · doi:10.1542/peds.2019-3447 · Cited by 1,798
The Lancet Commission on the future of care and clinical research in autism
Lord, C., Charman, T., Havdahl, A., Carbone, P., Anagnostou, E., Boyd, B., Carr, T., de Vries, P. J., Dissanayake, C., Divan, G., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)01541-5 · Cited by 924
Co-occurring psychiatric conditions in autism spectrum disorder
Rosen, T. E., Mazefsky, C. A., Vasa, R. A., & Lerner, M. D. (2018) · International Review of Psychiatry · doi:10.1080/09540261.2018.1450229 · Cited by 325
Solmi, M., Fornaro, M., Ostinelli, E. G., Zangani, C., Croatto, G., Monaco, F., Krinitski, D., Fusar‐Poli, P., & Correll, C. U. (2020) · World Psychiatry · doi:10.1002/wps.20765 · Cited by 324
Lai, M.-C., Anagnostou, E., Wiznitzer, M., Allison, C., & Baron-Cohen, S. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30034-x · Cited by 250
Stringaris, A. K., Vidal‐Ribas, P., Brotman, M. A., & Leibenluft, E. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12823 · Cited by 232
Lemonnier, E., Villeneuve, N., Sonie, S., Serret, S., Rosier, A., Roue, M., Brosset, P., Viellard, M., Bernoux, D., Rondeau, S., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.10 · Cited by 218
Veenstra-VanderWeele, J., Cook, E. H., King, B. H., Zarevics, P., Cherubini, M., Walton-Bowen, K., Bear, M. F., Wang, P. P., & Carpenter, R. L. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.237 · Cited by 168
Self-citationThe Emerging Clinical Neuroscience of Autism Spectrum Disorder
Muhle, R., Reed, H. E., Stratigos, K. A., & Veenstra-VanderWeele, J. M. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.4685 · Cited by 176
Self-citationRisk Factors for Unhealthy Weight Gain and Obesity among Children with Autism Spectrum Disorder
Dhaliwal, K. K., Orsso, C. E., Richard, C., Haqq, A. M., & Zwaigenbaum, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133285 · Cited by 157
Siafis, S., Çıray, O., Wu, H., Schneider‐Thoma, J., Bighelli, I., Krause, M., Rodolico, A., Ceraso, A., Deste, G., Huhn, M., et al. (2022) · Molecular Autism · doi:10.1186/s13229-022-00488-4 · Cited by 148
Fleury-Teixeira, P., Caixeta, F. V., da Silva, L. C. R., Brasil-Neto, J. P., & Malcher‐Lopes, R. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01145 · Cited by 140
Fallah, M. S., Shaikh, M. R., Neupane, B., Rusiecki, D. R., Bennett, T. A., & Beyene, J. (2019) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0115 · Cited by 116
Campbell, A. S., Needham, B. D., Meyer, C. R., Tan, J. H. J., Conrad, M. C., Preston, G. M., Bolognani, F., Rao, S. G., Heussler, H., Griffith, R., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01683-9 · Cited by 112
Rodrigues, R., Lai, M., Beswick, A., Gorman, D. A., Anagnostou, E., Szatmari, P., Anderson, K. K., & Ameis, S. H. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13305 · Cited by 98
Insular function in autism: Update and future directions in neuroimaging and interventions
Nomi, J. S., Molnar-Szakacs, I., & Uddin, L. Q. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.015 · Cited by 98
Translating dynamic defense patterns from rodents to people
Blanchard, D. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.001 · Cited by 94
Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders
Gandhi, T., & Lee, C. C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592710 · Cited by 97
de Pablo, G. S., Jordá, C. P., Vaquerizo‐Serrano, J., Moreno, C., Cabras, A., Arango, C., Hernandez, P. A., Veenstra-VanderWeele, J. M., Simonoff, E. A., Fusar‐Poli, P., et al. (2022) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2022.03.033 · Cited by 95
Self-citationKloosterboer, S. M., de Winter, B. C. M., Reichart, C. G., Kouijzer, M. E. J., de Kroon, M. M. J., van Daalen, E., Ester, W. A., Rieken, R., Dieleman, G. C., van Altena, D., et al. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14465 · Cited by 79
Siafis, S., Çıray, R. O., Schneider‐Thoma, J., Bighelli, I., Krause, M., Rodolico, A., Ceraso, A., Deste, G., Huhn, M., Fraguas, D., et al. (2020) · Molecular Autism · doi:10.1186/s13229-020-00372-z · Cited by 76
Lee, T.-M., Lee, K.-M., Lee, C.-Y., Lee, H., Tam, K., & Loh, E. (2020) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867420952540 · Cited by 75
Clinical trials in autism spectrum disorder: evidence, challenges and future directions
Anagnostou, E. A. (2018) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000542 · Cited by 74
Systematic review and guide to management of core and psychiatric symptoms in youth with autism
Ameis, S. H., Kassee, C., Corbett-Dick, P., Cole, L. L., Dadhwal, S., Lai, M., Veenstra-VanderWeele, J. M., & Correll, C. U. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12918 · Cited by 64
Self-citationSabus, A., Feinstein, J. A., Romani, P. W., Goldson, E., & Blackmer, A. B. (2019) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2238 · Cited by 64
Effects of Risperidone in Autistic Children and Young Adults: A Systematic Review and Meta-Analysis
Mano‐Sousa, B. J., Pedrosa, A. M., Alves, B. C., Galduróz, J. C. F., Belo, V. S., Chaves, V. E., & Duarte‐Almeida, J. M. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200529151741 · Cited by 62
Clinical practice guidelines for autism spectrum disorders
Subramanyam, A., Mukherjee, A., Dave, M., & Chavda, K. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_542_18 · Cited by 59
Coleman, D. M., Adams, J. B., Anderson, A. L., & Frye, R. E. (2019) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0121 · Cited by 56
On Behalf of the ISACA Guideline Working Group, D’Alò, G. L., De Crescenzo, F., Amato, L., Cruciani, F., Davoli, M., Fulceri, F., Minozzi, S., Mitrova, Z., Morgano, G. P., et al. (2021) · Health and Quality of Life Outcomes · doi:10.1186/s12955-021-01669-0 · Cited by 54
Cognitive impairment in psychiatric diseases: Biomarkers of diagnosis, treatment, and prevention
Wang, Y., Meng, W., Liu, Z., An, Q., & Hu, X. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1046692 · Cited by 51
Epilepsy and Psychiatric Comorbidities: Drug Selection
Mula, M. (2017) · Current Treatment Options in Neurology · doi:10.1007/s11940-017-0483-0 · Cited by 49
Iffland, M., Livingstone, N., Jorgensen, M. L., Hazell, P., & Gillies, D. M. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011769.pub2 · Cited by 58
Pharmacotherapy of Disruptive and Impulse Control Disorders
Reeves, G. M., Wehring, H. J., & Riddle, M. A. (2017) · Wiley eBooks · doi:10.1002/9781119092254.ch25 · Cited by 47
Fuentes, J., Parellada, M., Georgoula, C., Oliveira, G., Marret, S., Crutel, V., Severo, C. A., Lambert, E., Pénélaud, P., Ravel, D., et al. (2023) · Autism Research · doi:10.1002/aur.3005 · Cited by 46
Li, Y., Li, Y., & Xiang, D.-X. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1528-6 · Cited by 52
Aripiprazole in Children and Adolescents
Coustals, N., Ménard, M.-L., & Cohen, D. (2020) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2020.0014 · Cited by 45
Manter, M. A., Birtwell, K. B., Bath, J., Friedman, N. D. B., Keary, C. J., Neumeyer, A. M., Palumbo, M. L., Thom, R. P., Stonestreet, E., Brooks, H., et al. (2025) · BMC Medicine · doi:10.1186/s12916-024-03814-0 · Cited by 51
“…and aripiprazole have shown similar efficacy and safety profiles in comparison clinical trials [136, 137], though one meta-analysis on pharmacological treat-ment of irritability and problem behaviors in ASD did report that the number of subjects needed to treat was lower for risperidone [138].”
Risperidone or Aripiprazole Can Resolve Autism Core Signs and Symptoms in Young Children: Case Study
Alsayouf, H. A., Talo, H., Biddappa, M. L., & Reyes, E. D. L. (2021) · Children · doi:10.3390/children8050318 · Cited by 44
Emerging drugs for the treatment of irritability associated with autism spectrum disorder
Shamabadi, A., Karimi, H., Bahri, R. A., Motavaselian, M., & Akhondzadeh, S. (2024) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2024.2313650 · Cited by 46
Understanding, Assessing, and Intervening with Emotion Dysregulation in Autism Spectrum Disorder
Keluskar, J. L., Reicher, D., Gorecki, A., Mazefsky, C. A., & Crowell, J. A. (2021) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2020.10.013 · Cited by 51
Dopamine Dysregulation in Reward and Autism Spectrum Disorder
Blum, K., Bowirrat, A., Sunder, K. R., Thanos, P. K., Hanna, C., Gold, M. S., Dennen, C. A., Elman, I., Murphy, K. T., & Makale, M. T. (2024) · Brain Sciences · doi:10.3390/brainsci14070733 · Cited by 47
Pan, P., Fu, A.-T., & Yeh, C. (2018) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0068 · Cited by 41
Resveratrol in Autism Spectrum Disorders: Behavioral and Molecular Effects
Malaguarnera, M., Khan, H. Z., & Cauli, O. (2020) · Antioxidants · doi:10.3390/antiox9030188 · Cited by 42
Uso da Cannabis medicinal e autismo
Lima, M. C. M., Valênça, M. M., Machado, C. E., Pereira, M. E. D. M., & Brant, P. K. (2020) · Jornal Memorial da Medicina · doi:10.37085/jmmv2.n1.2020.pp.5-14 · Cited by 37
Bell, E., Boyce, P. M., Porter, R., Bryant, R. A., & Malhi, G. S. (2021) · CNS Drugs · doi:10.1007/s40263-021-00823-y · Cited by 37
Maniram, J., Karrim, S. B., Oosthuizen, F., & Wiafe, E. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s371013 · Cited by 36
Iles, A. N. (2021) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2021.04.003 · Cited by 37
The evidence-based choice for antipsychotics in children and adolescents should be guaranteed
Putignano, D., Clavenna, A., Reale, L., & Bonati, M. (2019) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-019-02641-0 · Cited by 21
Sulforaphane treatment for autism spectrum disorder: A systematic review
McGuinness, G., & Kim, Y. (2020) · EXCLI journal · doi:10.17179/excli2020-2487 · Cited by 34
The role of drugs in the treatment of autism
Turner, M. (2020) · Australian Prescriber · doi:10.18773/austprescr.2020.054 · Cited by 37
Wang, Y., Wang, M.-J., Rong, Y., He, H.-Z., & Yang, C.-J. (2019) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2019.03.007 · Cited by 33
Li, Y., Zhang, X., & Li, Y. (2019) · CNS Spectrums · doi:10.1017/s1092852919001603 · Cited by 33
Prescriber's Guide – Children and Adolescents
Stahl, S. M. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108561402 · Cited by 33
Crutel, V., Lambert, E., Pénélaud, P., Severo, C. A., Fuentes, J., Rosier, A., Amaia Hervas, G., Marret, S., Oliveira, G., Parellada, M., et al. (2020) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04709-8 · Cited by 32
Safety and tolerability of antipsychotic agents in neurodevelopmental disorders: a systematic review
Iasevoli, F., Barone, A., Buonaguro, E. F., Vellucci, L., & de Bartolomeis, A. (2020) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2020.1820985 · Cited by 30
Masi, A., Lampit, A., DeMayo, M. M., Glozier, N., Hickie, I. B., & Guastella, A. J. (2017) · Psychological Medicine · doi:10.1017/s0033291716003457 · Cited by 30
Menezes, M., & Mazurek, M. O. (2021) · Research in Autism · doi:10.1016/j.rasd.2021.101740 · Cited by 29
Psychotropic medications for highly vulnerable children
McLaren, J., Barnett, E. R., Concepción-Zayas, M. T., Lichtenstein, J. D., Acquilano, S. C., Schwartz, L. M., Woloshin, S., & Drake, R. E. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1445720 · Cited by 29
Investigational drugs in early-stage clinical trials for autism spectrum disorder
Hong, M. P., & Erickson, C. A. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1649656 · Cited by 27
Constantino, J. N., Strom, S., Bunis, M., Nadler, C. B., Rodgers, T. A., LePage, J., Cahalan, C., Stockreef, A., Evans, L., Jones, R., et al. (2020) · Current Psychiatry Reports · doi:10.1007/s11920-020-1127-8 · Cited by 34
Northrup, J. B., Goodwin, M. S., Montrenes, J. J., Vezzoli, J., Golt, J., Peura, C. B., Siegel, M. S., & Mazefsky, C. A. (2020) · Autism · doi:10.1177/1362361320908108 · Cited by 30
Comorbidities in Youth with Bipolar Disorder: Clinical Features and Pharmacological Management
Sesso, G., Brancati, G. E., & Masi, G. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220706104117 · Cited by 31
Han, Y. M. Y., Chan, M. M. Y., Shea, C. K., Mo, F. Y. M., Yiu, K. W. K., Chung, R. C. K., Cheung, M., & Chan, A. S.-Y. (2023) · Autism · doi:10.1177/13623613231169547 · Cited by 32
Samara, M. T., Goldberg, Y., Levine, S. Z., Furukawa, T. A., Geddes, J. R., Cipriani, A., Davis, J. M., & Leucht, S. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30331-0 · Cited by 26
Pervin, M. M., Ahmed, H. U., & Hagmayer, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.834783 · Cited by 35
Stoddard, J., Zik, J. B., Mazefsky, C. A., Dechant, B., & Gabriels, R. L. (2019) · Behavior Therapy · doi:10.1016/j.beth.2019.09.006 · Cited by 25
Nanjappa, M. S., Voyiaziakis, E., Pradhan, B., & Thippaiah, S. M. (2020) · CNS Spectrums · doi:10.1017/s109285292000214x · Cited by 24
Liu, C., Wang, Y., Deng, J., Lin, J., Hu, C., Li, Q., & Xu, X. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.682054 · Cited by 25
on behalf of the ISACA guideline working group, D’Alò, G. L., Crescenzo, F. D., Amato, L., Cruciani, F., Davoli, M., Fulceri, F., Minozzi, S., Mitrova, Z., Morgano, G. P., et al. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02956-8 · Cited by 26
Kouhbanani, S. S., Khosrorad, R., Zarenezhad, S., & Arabi, S. M. (2021) · Archives of Iranian Medicine · doi:10.34172/aim.2021.76 · Cited by 23
Psychotropic Use Among Youths With Intellectual and Developmental Disabilities
McLaren, J., Lichtenstein, J. D., Metcalfe, J. D., Charlot, L., Drake, R. E., & Beasley, J. B. (2021) · Psychiatric Services · doi:10.1176/appi.ps.201900465 · Cited by 21
Behavioral Management of Children With Autism in the Emergency Department
Wolpert, K. H., Kodish, I. M., Kim, S., & Uspal, N. G. (2022) · Pediatric Emergency Care · doi:10.1097/pec.0000000000002886 · Cited by 20
Montagner, P. S. S., Medeiros, W., da Silva, L. C. R., Borges, C. N., Brasil-Neto, J. P., Barbosa, V. D. D. S., Caixeta, F. V., & Malcher‐Lopes, R. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1210155 · Cited by 21
Kalvin, C. B., Gladstone, T. R., Jordan, R. P., Rowley, S., Marsh, C. L., Ibrahim, K., & Sukhodolsky, D. G. (2020) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04627-9 · Cited by 23
Lonchampt, S., Gerber, F., Aubry, J., Desmeules, J. A., Kosel, M., & Besson, M. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.614825 · Cited by 19
Rizzo, R., & Pavone, P. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1211007 · Cited by 21
Alsayouf, H. A., Talo, H., Biddappa, M. L., Qasaymeh, M. M., Qasem, S. A., & Reyes, E. D. L. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s277294 · Cited by 17
Clifford, P. J., Gevers, C., Jonkman, K. M., Boer, F., & Begeer, S. (2022) · Autism Research · doi:10.1002/aur.2800 · Cited by 16
van Andel, D. M., Sprengers, J. J., Königs, M., de Jonge, M. V., & Bruining, H. (2023) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05841-3 · Cited by 17
New Assessments and Treatments in ASD
Choueiri, R., & Zimmerman, A. W. (2017) · Current Treatment Options in Neurology · doi:10.1007/s11940-017-0443-8 · Cited by 17
Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder
Aaron, E., Montgomery, A. K., Ren, X., Guter, S. J., Anderson, G. M., Carneiro, A. M. D., Jacob, S., Mosconi, M. W., Pandey, G. N., Cook, E. H., et al. (2019) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-019-03989-z · Cited by 17
Self-citationAutism Spectrum Disorder and Epilepsy: Pathogenetic Mechanisms and Therapeutic Implications
Giliberti, A., Frisina, A. M., Giustiniano, S., Carbonaro, Y., Roccella, M., & Nardello, R. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14072431 · Cited by 18
Brito, A. R., Vairo, G. D. P. T., Dias, A. P. B. H., Olej, B., Nascimento, O. J. M., & Vasconcelos, M. M. (2020) · Jornal de Pediatria · doi:10.1016/j.jped.2019.10.012 · Cited by 16
Mazza, J. A. D. S., Ferreira, L. S., Martins-Vieira, A. D. F., Beserra, D. D. L., Rodrigues, V. A., Malcher‐Lopes, R., & Caixeta, F. V. (2024) · Pharmaceuticals · doi:10.3390/ph17060686 · Cited by 15
Potential of cannabinoids as treatments for autism spectrum disorders
Nezgovorova, V., Ferretti, C. J., Taylor, B. P., Shanahan, E. C., Uzunova, G., Hong, K., Devinsky, O., & Hollander, E. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.02.048 · Cited by 16
PLXNA2 and LRRC40 as candidate genes in autism spectrum disorder
Pijuan, J., Ortigoza‐Escobar, J. D., Ortiz, J., Alcalá, A. M., Calvo, M. C. C., Cubells, M., Hernando‐Davalillo, C., Palau, F., & Hoenicka, J. (2021) · Autism Research · doi:10.1002/aur.2502 · Cited by 14
Georgoula, C., Ferrín, M., Pietraszczyk-Kędziora, B., Amaia Hervas, G., Marret, S., Oliveira, G., Rosier, A., Crutel, V., Besse, E., Severo, C. A., et al. (2022) · Child Psychiatry & Human Development · doi:10.1007/s10578-022-01328-5 · Cited by 15
Pervin, M. M., & Hagmayer, Y. (2022) · Administration and Policy in Mental Health and Mental Health Services Research · doi:10.1007/s10488-022-01205-2 · Cited by 14
Mishra, A., Singla, R., Kumar, R., Sharma, A. R., Joshi, R., Sarma, P., Kaur, G., Prajapat, M., Bhatia, A., & Medhi, B. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00270 · Cited by 14
Kurokawa, S., Nomura, K., Miyaho, K., Sanada, K., Iwamoto, C., Naraoka, M., Yoneda, S., Tomizawa, Y., Sawae, Y., Iwanaga, R., et al. (2021) · Autism Research · doi:10.1002/aur.2549 · Cited by 13
YILMAZ, Z. K., & Al‐Taie, A. (2022) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-022-01530-4 · Cited by 13
Mikami, K., Watanabe, N., Tochio, T., Kimoto, K., Akama, F., & Yamamoto, K. (2023) · Microorganisms · doi:10.3390/microorganisms11041008 · Cited by 17
Breaux, R., Dunn, N. C., Swanson, C. S., Larkin, E., Waxmonsky, J. G., & Baweja, R. K. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.794044 · Cited by 12
The effect of stimulants on irritability in autism comorbid with ADHD: a systematic review
Ghanizadeh, A. J., Molla, M., & Olango, G. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s194022 · Cited by 12
Myers, S. M., & Challman, T. D. (2018) · American Academy of PediatricsItasca, IL eBooks · doi:10.1542/9781610021357-19 · Cited by 12
The American Psychiatric Association Publishing Textbook of Psychiatry
Roberts, L. W. (2019) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615372980 · Cited by 14
Burman, D., Ramanujam, K., Manzar, M. D., Chattu, V. K., Spence, D. W., Zaki, N. F. W., Jahrami, H., & Pandi-Perumal, S. R. (2023) · Sleep and Vigilance · doi:10.1007/s41782-022-00222-3 · Cited by 12
Irritability Disorders in Adults
Yager, J. (2020) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001158 · Cited by 13
Ferguson, E. F., Russell, K. M., Licona, S., Cai, R. Y., Frazier, T. W., Vivanti, G., Gengoux, G. W., Hardan, A. Y., & Uljarević, M. (2024) · Autism Research · doi:10.1002/aur.3289 · Cited by 11
Self-citation
Metadata
- Authors
- Fung, L. K., Mahajan, R., Nozzolillo, A., Bernal, P., Krasner, A., Jo, B., Coury, D., Whitaker, A., Veenstra-Vanderweele, J., & Hardan, A. Y.
- Affiliations
- Stanford University (US)
- Kennedy Krieger Institute (US)
- Massachusetts General Hospital (US)
- Kaiser Permanente Northern California (US)
- NewYork–Presbyterian Hospital (US)
- The Ohio State University (US)
- ORCID
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2016-02-01
- Volume
- 137
- Issue
- Supplement_2
- Pages
- S124-S135
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2280843891
- Cited by
- 294
- References
- 63
- Citations by year
- 2026: 18 · 2025: 25 · 2024: 27 · 2023: 34 · 2022: 34 · 2021: 49 · 2020: 44 · 2019: 24 · 2018: 21 · 2017: 11 · 2016: 7
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- autism spectrum disorder, irritability, aggression, behavioral problems, pharmacotherapy, risperidone, aripiprazole, adverse drug reactions, sedation, extrapyramidal symptoms, weight gain, youth
- MeSH terms
- Problem Behavior, Autism Spectrum Disorder, Aripiprazole, Adolescent, Child, Child Development Disorders, Pervasive, Child, Preschool, Humans, Irritable Mood, Antipsychotic Agents, Self-Injurious Behavior, Risperidone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
