Cited by 2,819Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesFamily and Disability Support Research

Autism spectrum disorder

Open access
Lord, Catherine, Elsabbagh, Mayada, Baird, Gillian, Veenstra-Vanderweele, Jeremy·2018·The Lancet

Abstract

Autism spectrum disorder is a term used to describe a constellation of early-appearing social communication deficits and repetitive sensory-motor behaviours associated with a strong genetic component as well as other causes. The outlook for many individuals with autism spectrum disorder today is brighter than it was 50 years ago; more people with the condition are able to speak, read, and live in the community rather than in institutions, and some will be largely free from symptoms of the disorder by adulthood. Nevertheless, most individuals will not work full-time or live independently. Genetics and neuroscience have identified intriguing patterns of risk, but without much practical benefit yet. Considerable work is still needed to understand how and when behavioural and medical treatments can be effective, and for which children, including those with substantial comorbidities. It is also important to implement what we already know and develop services for adults with autism spectrum disorder. Clinicians can make a difference by providing timely and individualised help to families navigating referrals and access to community support systems, by providing accurate information despite often unfiltered media input, and by anticipating transitions such as family changes and school entry and leaving.

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Crossref · 10.1016/s0140-6736(18)31129-2

Cites

137 of 137 references verified0 citation errors · 0 not checkable

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  • Adaptive behaviour is a challenge for many individuals with ASD, who have scores below what would be expected based on IQ.

    “Adaptive behaviour is a challenge for many individuals with ASD, who have scores below what would be expected based on IQ 286 .”

    From Autism spectrum disorder (2020) · cites this paper as [286]

    The “ASD in adulthood” section reports that only about 25% of US adults with ASD and average intelligence live in their own households, supporting the point that everyday functioning can be challenging despite IQ. It does not report adaptive-behaviour scores or compare those scores with values expected from IQ. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • Children and adults with ASD/ADHD are associated with coexisting mental and neurologic conditions (such as oppositional and conduct disorders, tic disorders, epilepsy, depression, anxiety, and substance use disorders).

    “Findings from previous studies and reviews have suggested that children and adults with ASD/ADHD are associated with coexisting mental and neurologic conditions (such as oppositional and conduct disorders, tic disorders, epilepsy, depression, anxiety, and substance use disorders).3,4,5,57”
  • As children and young persons with ASD/ADHD age, they often experience emotional and social difficulties.

    “As children and young persons with ASD/ADHD age, they often experience emotional and social difficulties.3,4,5”
  • ASD pathogenesis involves interactions between genetic, immune system, environment and in utero factors.

    “The pathogenesis involves the interactions between genetic, immune system, environment and in utero factors [207].”

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Cites

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Research works printed but not linked: 4

  1. [16]Weitlauf AS, McPheeters ML, Peters B, Therapies for children with autism spectrum disorder: behavioral interventions update. Comparative Effectiveness Review No. 137. Rockville, MD: Agency for Healthcare Research and Quality, 2014. 25210724
  2. [17]National Institute for Health and Care Excellence. Autism spectrum disorder in adults: diagnosis and management. June 27, 2012 https://www.nice.org.uk/guidance/CG142 (accessed July 11, 2018). 32186834
  3. [39]Brugha TS. The psychiatry of adult autism and Asperger syndrome: a practical guide. Oxford: Oxford University Press, 2018.
  4. [108]Weitlauf AS, Sathe NA, McPheeters ML, Warren Z. Interventions targeting sensory challenges in children with autism spectrum disorder—an update. Comparative Effectiveness Review No. 186. Rockville, MD: Agency for Healthcare Research and Quality, 2017. 29064644

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Authors
Lord, C., Elsabbagh, M., Baird, G., & Veenstra-Vanderweele, J.
Affiliations
  • NewYork–Presbyterian Hospital (US)
  • McGill University (CA)
  • Kings Health Partners (GB)
Corresponding author
Lord, Catherine
Venue
The Lancet
Publisher
Elsevier BV
Published
2018-08
Volume
392
Issue
10146
Pages
508-520
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
OpenAlex
W2886989735
Cited by
2,819
References
137
Citations by year
2026: 559 · 2025: 492 · 2024: 420 · 2023: 403 · 2022: 333 · 2021: 285 · 2020: 192 · 2019: 83 · 2018: 24 · 2017: 21 · 2016: 2 · 2012: 1
FWCI
19.49
Type
journal article
Language
en
Open access
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • Weill Cornell Medical College
  • Health Canada
  • Fonds de Recherche du Québec - Santé
  • National Institute of Mental Health (R01MH104423)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD081199)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Social Sciences › Psychology › Clinical Psychology › Family and Disability Support Research
Keywords
autism spectrum disorder, social communication deficits, genetic risk factors, comorbidities, coming of age, community support services, family support, media misinformation
MeSH terms
Autism Spectrum Disorder, Adolescent, Adult, Child, Humans, Risk Factors

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