Dysfunction in the neural circuitry of emotion regulation–a possible prelude to violence
Abstract
Emotion is normally regulated in the human brain by a complex circuit consisting of the orbital frontal cortex, amygdala, anterior cingulate cortex, and several other interconnected regions. There are both genetic and environmental contributions to the structure and function of this circuitry. We posit that impulsive aggression and violence arise as a consequence of faulty emotion regulation. Indeed, the prefrontal cortex receives a major serotonergic projection, which is dysfunctional in individuals who show impulsive violence. Individuals vulnerable to faulty regulation of negative emotion are at risk for violence and aggression. Research on the neural circuitry of emotion regulation suggests new avenues of intervention for such at-risk populations.
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Dysfunction in the prefrontal cortex and amygdala may lead to heightened emotional responses and increased impulsive behavior.
“Dysfunction in the above areas may lead to heightened emotional responses and increased impulsive behavior (13).”
From Abnormal functional connectivity associated with emotional dysregulation in children with attention-deficit/hyperactivity disorder (2025) · cites this paper as [13]
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- Authors
- Davidson, R. J., Putnam, K. M., & Larson, C. L.
- Affiliations
- University of Wisconsin System (US)
- Corresponding author
- Davidson, Richard J.
- Venue
- Science
- Published
- 2000-07-28
- Volume
- 289
- Issue
- 5479
- Pages
- 591-594
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984030600
- Cited by
- 1,894
- References
- 5
- Citations by year
- 2026: 26 · 2025: 35 · 2024: 41 · 2023: 45 · 2022: 52 · 2021: 66 · 2020: 61 · 2019: 79 · 2018: 96 · 2017: 95 · 2016: 87 · 2015: 95 · 2014: 106 · 2013: 104 · 2012: 84
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh040747-14)
- National Institute of Mental Health (P50-MH 52354, P50MH052354, MH40747, MH 43454)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- emotion regulation, neural circuits, impulsive aggression, violence, orbitofrontal cortex, amygdala, anterior cingulate cortex, serotonergic system, prefrontal cortex, negative emotions, genetic and environmental contributions, vulnerable populations, intervention
- MeSH terms
- Affect, Aggression, Amygdala, Anger, Animals, Brain, Cues, Emotions, Humans, Impulsive Behavior, Neural Pathways, Serotonin, Violence, Prefrontal Cortex
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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