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Vital Signs: Update on Zika Virus–Associated Birth Defects and Evaluation of All U.S. Infants with Congenital Zika Virus Exposure — U.S. Zika Pregnancy Registry, 2016
Open accessAbstract
BACKGROUND: In collaboration with state, tribal, local, and territorial health departments, CDC established the U.S. Zika Pregnancy Registry (USZPR) in early 2016 to monitor pregnant women with laboratory evidence of possible recent Zika virus infection and their infants. METHODS: This report includes an analysis of completed pregnancies (which include live births and pregnancy losses, regardless of gestational age) in the 50 U.S. states and the District of Columbia (DC) with laboratory evidence of possible recent Zika virus infection reported to the USZPR from January 15 to December 27, 2016. Birth defects potentially associated with Zika virus infection during pregnancy include brain abnormalities and/or microcephaly, eye abnormalities, other consequences of central nervous system dysfunction, and neural tube defects and other early brain malformations. RESULTS: During the analysis period, 1,297 pregnant women in 44 states were reported to the USZPR. Zika virus-associated birth defects were reported for 51 (5%) of the 972 fetuses/infants from completed pregnancies with laboratory evidence of possible recent Zika virus infection (95% confidence interval [CI] = 4%-7%); the proportion was higher when restricted to pregnancies with laboratory-confirmed Zika virus infection (24/250 completed pregnancies [10%, 95% CI = 7%-14%]). Birth defects were reported in 15% (95% CI = 8%-26%) of fetuses/infants of completed pregnancies with confirmed Zika virus infection in the first trimester. Among 895 liveborn infants from pregnancies with possible recent Zika virus infection, postnatal neuroimaging was reported for 221 (25%), and Zika virus testing of at least one infant specimen was reported for 585 (65%). CONCLUSIONS AND IMPLICATIONS FOR PUBLIC HEALTH PRACTICE: These findings highlight why pregnant women should avoid Zika virus exposure. Because the full clinical spectrum of congenital Zika virus infection is not yet known, all infants born to women with laboratory evidence of possible recent Zika virus infection during pregnancy should receive postnatal neuroimaging and Zika virus testing in addition to a comprehensive newborn physical exam and hearing screen. Identification and follow-up care of infants born to women with laboratory evidence of possible recent Zika virus infection during pregnancy and infants with possible congenital Zika virus infection can ensure that appropriate clinical services are available.
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Citations
Cites
Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians
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Self-citationHonein, M. A., Dawson, A. L., Petersen, E. E., Jones, A. M., Lee, E. H., Yazdy, M. M., Ahmad, N., Macdonald, J., Evert, N., Bingham, A., et al. (2017) · JAMA · doi:10.1001/jama.2016.19006 · Cited by 765
Self-citationvan der Linden, V., Pessoa, A., Dobyns, W., Barkovich, A. J., Júnior, H. V. D. L., Filho, E. L. R., Ribeiro, E. M., Leal, M. D. C., Coimbra, P. P. D. A., Aragão, M. D. F. V. V., et al. (2016) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6547e2 · Cited by 443
Self-citationInterim Guidance for Interpretation of Zika Virus Antibody Test Results
Rabe, I. B., Staples, J. E., Villanueva, J., Hummel, K. B., Johnson, J. A., Rose, L., MTS, Hills, S., Wasley, A., Fischer, M., et al. (2016) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6521e1 · Cited by 274
Zika Virus RNA Replication and Persistence in Brain and Placental Tissue
Bhatnagar, J., Rabeneck, D. B., Martines, R. B., Reagan-Steiner, S., Ermias, Y., Estetter, L. B. C., Suzuki, T., Ritter, J., Keating, M. K., Hale, G., et al. (2017) · Emerging Infectious Diseases · doi:10.3201/eid2303.161499 · Cited by 215
Self-citationZika Virus Infection Among U.S. Pregnant Travelers — August 2015–February 2016
Meaney‐Delman, D. M., Hills, S. L., Williams, C. L., Galang, R. R., Iyengar, P., Hennenfent, A. K., Rabe, I. B., Panella, A. J., Oduyebo, T., Honein, M. A., et al. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6508e1 · Cited by 136
Self-citationRussell, K. E. R., Oliver, S. E., Lewis, L. M., Barfield, W. D., Cragan, J. D., Meaney‐Delman, D. M., Staples, J. E., Fischer, M., Peacock, G., Oduyebo, T., et al. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6533e2 · Cited by 130
Self-citationOduyebo, T., Igbinosa, I. I., Petersen, E. E., Polen, K. N. D., Pillai, S. K., Ailes, E. C., Villanueva, J. M., Newsome, K., Fischer, M., Gupta, P. M., et al. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6529e1 · Cited by 94
Self-citationA Prognostic Neonatal Neuroimaging Scale for Symptomatic Congenital Cytomegalovirus Infection
Alarcón, A., Martínez-Biarge, M., Cabañas, F., et al. (2016) · Neonatology · doi:10.1159/000446690 · Cited by 88
Possible Zika Virus Infection Among Pregnant Women — United States and Territories, May 2016
Simeone, R. M., Shapiro‐Mendoza, C. K., Meaney‐Delman, D. M., et al. (2016) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6520e1 · Cited by 45
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Cited by
Shapiro-Mendoza, C. K., Rice, M. E., Galang, R. R., Fulton, A. C., VanMaldeghem, K., Prado, M. V., Ellis, E., Anesi, M. S., Simeone, R. M., Petersen, E. E., et al. (2017) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6623e1 · Cited by 268
Self-citationNielsen-Saines, K., Brasil, P., Kerin, T., Vasconcelos, Z., Gabaglia, C. R., Damasceno, L., Pone, M., Abreu de Carvalho, L. M., Pone, S. M., Zin, A. A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0496-1 · Cited by 268
Neurocognitive impacts of arbovirus infections
Clé, M., Eldin, P., Briant, L., Lannuzel, A., Simonin, Y., Van de Perre, P., Cabié, A., & Salinas, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01904-3 · Cited by 67
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Metadata
- Authors
- Reynolds, M. R., Jones, A. M., Petersen, E. E., Lee, E. H., Rice, M. E., Bingham, A., Ellington, S. R., Evert, N., Reagan-Steiner, S., Oduyebo, T., Brown, C. M., Martin, S., Ahmad, N., Bhatnagar, J., Macdonald, J., Gould, C., Fine, A. D., Polen, K. D., Lake-Burger, H., Hillard, C. L., Hall, N., Yazdy, M. M., Slaughter, K., Sommer, J. N., Adamski, A., Raycraft, M., Fleck-Derderian, S., Gupta, J., Newsome, K., Baez-Santiago, M., Slavinski, S., White, J. L., Moore, C. A., Shapiro-Mendoza, C. K., Petersen, L., Boyle, C., Jamieson, D. J., Meaney-Delman, D., Honein, M. A., U.S. Zika Pregnancy Registry Collaboration, U.S. Zika Pregnancy Registry Collaboration, Adair, J., Ruberto, I., Haselow, D. T., Im, L., Jilek, W., Lehmann, M. S., Olney, R., Porse, C. C., Ramstrom, K. C., Sowunmi, S., Marzec, N. S., Davis, K., Esponda-Morrison, B., Fraser, M. Z., O'Connor, C. A., Chung, W., Richardson, F., Sexton, T., Stocks, M. E., Woldai, S., Bundek, A. M., Zambri, J., Goldberg, C., Eisenstein, L., Jackson, J., Kopit, R., Logue, T., Mendoza, R., Feldpausch, A., Graham, T., Mann, S., Park, S. Y., Carter, K. K., Potts, E. J., Stevens, T., Simonson, S., Tonzel, J. L., Davis, S., Robinson, S., Hyun, J. K., Jenkins, E. M., Piccardi, M., Reid, L. D., Dunn, J. E., Higgins, C. A., Lin, A. E., Munshi, G. S., Sandhu, K., Scotland, S. J., Soliva, S., Copeland, G., Signs, K. A., Schiffman, E., Byers, P., Hand, S., Mulgrew, C. L., Hamik, J., Koirala, S., Ludwig, L. A., Fredette, C. R., Garafalo, K., Worthington, K., Ropri, A., Ade, J. N., Alaali, Z. S., Blog, D., Brunt, S. J., Bryant, P., Burns, A. E., Bush, S., Carson, K., Dean, A. B., Demarest, V., Dufort, E. M., Dupuis II, A. P., Sullivan-Frohm, A., Furuya, A. M., Fuschino, M., Glaze, V. H., Griffin, J., Hidalgo, C., Kulas, K. E., Lamson, D. M., Lance, L. A., Lee, W. T., Limberger, R., Many, P. S., Marchewka, M. J., Naizby, B. E., Polfleit, M., Popowich, M., Rahman, T., Rem, T., Robbins, A. E., Rowlands, J. V., Seaver, C., Seward, K. A., Smith, L., Sohi, I., St. George, K., Souto, M. I., Wester, R. E., Wong, S. J., Zeng, L., Ackelsberg, J., Alex, B., Ballen, V., Baumgartner, J., Bloch, D., Clark, S., Conners, E., Cooper, H., Davidson, A., Dentinger, C., Deocharan, B., DeVito, A., Fu, J., Hrusa, G., Iqbal, M., Iwamoto, M., Jones, L., Kubinson, H., Lash, M., Layton, M., Lee, C. T., Liu, D., McGibbon, E., Moy, M., Ngai, S., Parton, H. B., Peterson, E., Poy, J., Rakeman, J., Stoute, A., Thompson, C., Weiss, D., Westheimer, E., Winters, A., Younis, M., Chan, R. L., Cronquist, L. J., Caton, L., Lind, L., Nalluswami, K., Perella, D., Brady, D. S., Gosciminski, M., McAuley, P., Drociuk, D., Leedom, V., Witrick, B., Bollock, J., Hartel, M. B., Lucinski, L. S., McDonald, M., Miller, A. M., Ponson, T. A., Price, L., Nance, A. E., Peterson, D., Cook, S., Martin, B., Oltean, H., Neary, J., Baker, M. A., Cummons, K., Bryan, K., Arnold, K. E., Arth, A. C., Bollweg, B. C., Cragan, J. D., Dawson, A. L., Denison, A. M., Dziuban, E. J., Estetter, L., Silva-Flannery, L., Free, R. J., Galang, R. R., Gary, J., Goldsmith, C. S., Green, C., Hale, G. L., Hayes, H. M., Igbinosa, I., Keating, M. K., Khan, S., Kim, S. Y., Lampe, M., Lewis, A., Mai, C., Martines, R. B., Miers, B., Moore, J., Muehlenbachs, A., Nahabedian, J., Panella, A., Parihar, V., Patel, M. M., Rabeneck, D. B., Rasmussen, S. A., Ritter, J. M., Rollin, D. C., Sanders, J. H., Shieh, W.-J., Simeone, R. M., Simon, E. L., Sims, J. R., Spivey, P. J., Talley-McRae, H., Tshiwala, A. K., VanMaldeghem, K., Viens, L., Wainscott-Sargent, A., Williams, T., & Zaki, S.
- Venue
- MMWR. Morbidity and Mortality Weekly Report
- Published
- 2017-04-07
- Volume
- 66
- Issue
- 13
- Pages
- 366-373
- ISSN
- 0149-2195 (ISSN-L)
- 1545-861X
- OpenAlex
- W2604239467
- Cited by
- 282
- References
- 10
- FWCI
- 42.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Reynolds, M. R., Jones, A. M., Petersen, E. E., Lee, E. H., Rice, M. E., Bingham, A., Ellington, S. R., Evert, N., Reagan-Steiner, S., Oduyebo, T., Brown, C. M., Martin, S., Ahmad, N., Bhatnagar, J., Macdonald, J., Gould, C., Fine, A. D., Polen, K. D., Lake-Burger, H., . . . Zaki, S. (2017). Vital Signs: Update on Zika Virus–Associated Birth Defects and Evaluation of All U.S. Infants with Congenital Zika Virus Exposure — U.S. Zika Pregnancy Registry, 2016. MMWR. Morbidity and Mortality Weekly Report. https://doi.org/10.15585/mmwr.mm6613e1
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