The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Zika Virus RNA Replication and Persistence in Brain and Placental Tissue
Open accessAbstract
Zika virus is causally linked with congenital microcephaly and may be associated with pregnancy loss. However, the mechanisms of Zika virus intrauterine transmission and replication and its tropism and persistence in tissues are poorly understood. We tested tissues from 52 case-patients: 8 infants with microcephaly who died and 44 women suspected of being infected with Zika virus during pregnancy. By reverse transcription PCR, tissues from 32 (62%) case-patients (brains from 8 infants with microcephaly and placental/fetal tissues from 24 women) were positive for Zika virus. In situ hybridization localized replicative Zika virus RNA in brains of 7 infants and in placentas of 9 women who had pregnancy losses during the first or second trimester. These findings demonstrate that Zika virus replicates and persists in fetal brains and placentas, providing direct evidence of its association with microcephaly. Tissue-based reverse transcription PCR extends the time frame of Zika virus detection in congenital and pregnancy-associated infections.
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Cites
Zika Virus Associated with Microcephaly
Mlakar, J., Korva, M., Tul, N., Popović, M., Poljšak-Prijatelj, M., Mraz, J., Kolenc, M., Resman Rus, K., Vesnaver Vipotnik, T., Fabjan Vodušek, V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1600651 · Cited by 2,884
The Brazilian Zika virus strain causes birth defects in experimental models
Cugola, F. R., Fernandes, I. R., Russo, F. B., Freitas, B. C., Dias, J. L. M., Guimarães, K. P., Benazzato, C., Almeida, N., Pignatari, G. C., Romero, S., et al. (2016) · Nature · doi:10.1038/nature18296 · Cited by 1,326
Zika virus impairs growth in human neurospheres and brain organoids
Garcez, P. P., Loiola, E. C., Madeiro da Costa, R., Higa, L. M., Trindade, P., Delvecchio, R., Nascimento, J. M., Brindeiro, R., Tanuri, A., & Rehen, S. K. (2016) · Science · doi:10.1126/science.aaf6116 · Cited by 1,184
Kourtis, A. P., Read, J. S., & Jamieson, D. J. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1213566 · Cited by 850
Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities
Driggers, R. W., Ho, C.-Y., Korhonen, E. M., Kuivanen, S., Jääskeläinen, A. J., Smura, T., Rosenberg, A., Hill, D. A., DeBiasi, R. L., Vezina, G., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1601824 · Cited by 831
Self-citationZika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice
Li, C., Xu, D., Ye, Q., Hong, S., Jiang, Y., Liu, X., Zhang, N., Shi, L., Qin, C.-F., & Xu, Z. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.04.017 · Cited by 749
Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells
Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Sandoval-Espinosa, C., Bershteyn, M., & Kriegstein, A. R. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.03.012 · Cited by 529
Characterization of Lethal Zika Virus Infection in AG129 Mice
Aliota, M. T., Caine, E. A., Walker, E. C., Larkin, K. E., Camacho, E., & Osorio, J. E. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004682 · Cited by 322
Cited by
Reynolds, M. R., Jones, A. M., Petersen, E. E., Lee, E. H., Rice, M. E., Bingham, A., Ellington, S. R., Evert, N., Reagan-Steiner, S., Oduyebo, T., et al. (2017) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6613e1 · Cited by 282
Self-citationPregnancy and infection: using disease pathogenesis to inform vaccine strategy
Vermillion, M. S., & Klein, S. L. (2018) · npj Vaccines · doi:10.1038/s41541-017-0042-4 · Cited by 39
Metadata
- Authors
- Bhatnagar, J., Rabeneck, D. B., Martines, R. B., Reagan-Steiner, S., Ermias, Y., Estetter, L. B. C., Suzuki, T., Ritter, J., Keating, M. K., Hale, G., Gary, J., Muehlenbachs, A., Lambert, A., Lanciotti, R., Oduyebo, T., Meaney-Delman, D., Bolaños, F., Saad, E. A. P., Shieh, W.-J., & Zaki, S. R.
- Venue
- Emerging Infectious Diseases
- Published
- 2017-03
- Volume
- 23
- Issue
- 3
- Pages
- 405-414
- ISSN
- 1080-6040 (ISSN-L)
- 1080-6059
- OpenAlex
- W2562513421
- Cited by
- 215
- References
- 8
- FWCI
- 32.65
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Bhatnagar, J., Rabeneck, D. B., Martines, R. B., Reagan-Steiner, S., Ermias, Y., Estetter, L. B. C., Suzuki, T., Ritter, J., Keating, M. K., Hale, G., Gary, J., Muehlenbachs, A., Lambert, A., Lanciotti, R., Oduyebo, T., Meaney-Delman, D., Bolaños, F., Saad, E. A. P., Shieh, W.-J., & Zaki, S. R. (2017). Zika Virus RNA Replication and Persistence in Brain and Placental Tissue. Emerging Infectious Diseases. https://doi.org/10.3201/eid2303.161499
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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