The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
Parkinson’s Disease: Etiology, Neuropathology, and Pathogenesis
Open accessAbstract
Parkinson’s disease (PD) is a common neurodegenerative disorder. While a number of nonmotor manifestations arise, the typical clinical features involve a movement disorder consisting of bradykinesia, resting tremor, and rigidity, with postural instability occurring at a later stage. The cause of PD is not known, but a number of genetic risk factors have now been characterized, as well as several genes which cause rare familial forms of PD. Environmental influences such as smoking, caffeine consumption, and pesticide exposure have been postulated to alter the risk of PD development, although the role of these remains unclear. The movement disorder arises due to the loss of dopaminergic neurons of the substantia nigra pars compacta, with the pathological hallmark being intracellular aggregates of α-synuclein, in the form of Lewy bodies and Lewy neurites. Several processes have been implicated in PD, including mitochondrial dysfunction, defective protein clearance mechanisms, and neuroinflammation, but the way in which these factors interact remains incompletely understood.
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Imaging the neural underpinnings of freezing of gait in Parkinson’s disease
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Metadata
- Authors
- John van Geest Centre for Brain Repair, D. O. C. N., Kouli, A., Torsney, K. M., Department of Medicine for the Elderly, C. U. H. N. F. T., Clinical Gerontology Unit, D. O. P. H. A. P. C., Kuan, W.-L., & John van Geest Centre for Brain Repair, D. O. C. N.
- Venue
- Parkinson’s Disease: Pathogenesis and Clinical Aspects
- Publisher
- Codon Publications
- Published
- 2018-12-22
- Pages
- 3-26
- OpenAlex
- W2906486676
- Cited by
- 507
- References
- 157
- FWCI
- 68.06
- Type
- book chapter
- Language
- en
- Open access
- hybrid
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- John van Geest Centre for Brain Repair, D. O. C. N., Kouli, A., Torsney, K. M., Department of Medicine for the Elderly, C. U. H. N. F. T., Clinical Gerontology Unit, D. O. P. H. A. P. C., Kuan, W.-L., & John van Geest Centre for Brain Repair, D. O. C. N. (2018). Parkinson’s Disease: Etiology, Neuropathology, and Pathogenesis. Parkinson’s Disease: Pathogenesis and Clinical Aspects. https://doi.org/10.15586/codonpublications.parkinsonsdisease.2018.ch1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
