The DOI matches its Crossref record; 76 of the 82 references it cites were found in a registry or an index.
Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶
Abstract
Photodynamic therapy (PDT) requires molecular oxygen during light irradiation to generate reactive oxygen species. Tumor hypoxia, either preexisting or induced by PDT, can severely hamper the effectiveness of PDT. Lowering the light irradiation dose rate or fractionating a light dose may improve cell kill of PDT-induced hypoxic cells but will have no effect on preexisting hypoxic cells. In this study hyperoxygenation technique was used during PDT to overcome hypoxia. C3H mice with transplanted mammary carcinoma tumors were injected with 12.5 mg/kg Photofrin and irradiated with 630 nm laser light 24 h later. Tumor oxygenation was manipulated by subjecting the animals to 3 atp (atmospheric pressure) hyperbaric oxygen or normobaric oxygen during PDT light irradiation. The results show a significant improvement in tumor response when PDT was delivered during hyperoxygenation. With hyperoxygenation up to 80% of treated tumors showed no regrowth after 60 days. In comparison, when animals breathed room air, only 20% of treated tumors did not regrow. To explore the effect of hyperoxygenation on tumor oxygenation, tumor partial oxygen pressure was measured with microelectrodes positioned in preexisting hypoxic regions before and during the PDT. The results show that hyperoxygenation may oxygenate preexisting hypoxic cells and compensate for oxygen depletion induced by PDT light irradiation. In conclusion, hyperoxygenation may provide effective ways to improve PDT efficiency by oxygenating both preexisting and treatment-induced cell hypoxia.
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“The availability of molecular oxygen during PDT has been shown to have a profound effect on treatment outcomes. 433 , 434”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [433]
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Cites
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Nanoparticles in Photodynamic Therapy
Lucky, S. S., Soo, K. C., & Zhang, Y. (2015) · Chemical Reviews · doi:10.1021/cr5004198 · Cited by 2,999
Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
Celli, J. P., Spring, B. Q., Rizvi, I., Evans, C. L., Samkoe, K. S., Verma, S., Pogue, B. W., & Hasan, T. G. (2010) · Chemical Reviews · doi:10.1021/cr900300p · Cited by 2,359
Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions
van Straten, D., Mashayekhi, V., de Bruijn, H., Oliveira, S., & Robinson, D. J. (2017) · Cancers · doi:10.3390/cancers9020019 · Cited by 1,042
The physics, biophysics and technology of photodynamic therapy
Wilson, B. C., & Patterson, M. S. (2008) · Physics in Medicine and Biology · doi:10.1088/0031-9155/53/9/r01 · Cited by 1,043
A Review of Progress in Clinical Photodynamic Therapy
Huang, Z. W. (2005) · Technology in Cancer Research & Treatment · doi:10.1177/153303460500400308 · Cited by 912
Self-citation
Metadata
- Authors
- Chen, Q., Huang, Z., Chen, H., Shapiro, H., Beckers, J., & Hetzel, F. W.
- Affiliations
- HealthONE (US)
- Venue
- Photochemistry and Photobiology
- Publisher
- American Society for Photobiology
- Published
- 2007-05-01
- Volume
- 76
- Issue
- 2
- Pages
- 197-203
- ISSN
- 0031-8655 (ISSN-L)
- OpenAlex
- W1958679672
- Cited by
- 124
- References
- 82
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P01CA043892)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- photodynamic therapy, tumor hypoxia, tumor oxygenation, hyperbaric oxygen therapy, normobaric oxygen, hyperoxygenation, reactive oxygen species, Photofrin, breast cancer
- MeSH terms
- Animals, Female, Male, Mammary Neoplasms, Experimental, Mice, Inbred C3H, Oxygen, Photochemotherapy, Photobiology, Mice
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