Cited by 124Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsCancer, Hypoxia, and Metabolism

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Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶

Chen, Qun, Huang, Zheng, Chen, Hua, Shapiro, Howard, Beckers, Jill, Hetzel, Fred W.·2007·Photochemistry and Photobiology

DOI 10.1562/0031-8655(2002)0760197iotrbm2.0.co2

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Abstract

Photodynamic therapy (PDT) requires molecular oxygen during light irradiation to generate reactive oxygen species. Tumor hypoxia, either preexisting or induced by PDT, can severely hamper the effectiveness of PDT. Lowering the light irradiation dose rate or fractionating a light dose may improve cell kill of PDT-induced hypoxic cells but will have no effect on preexisting hypoxic cells. In this study hyperoxygenation technique was used during PDT to overcome hypoxia. C3H mice with transplanted mammary carcinoma tumors were injected with 12.5 mg/kg Photofrin and irradiated with 630 nm laser light 24 h later. Tumor oxygenation was manipulated by subjecting the animals to 3 atp (atmospheric pressure) hyperbaric oxygen or normobaric oxygen during PDT light irradiation. The results show a significant improvement in tumor response when PDT was delivered during hyperoxygenation. With hyperoxygenation up to 80% of treated tumors showed no regrowth after 60 days. In comparison, when animals breathed room air, only 20% of treated tumors did not regrow. To explore the effect of hyperoxygenation on tumor oxygenation, tumor partial oxygen pressure was measured with microelectrodes positioned in preexisting hypoxic regions before and during the PDT. The results show that hyperoxygenation may oxygenate preexisting hypoxic cells and compensate for oxygen depletion induced by PDT light irradiation. In conclusion, hyperoxygenation may provide effective ways to improve PDT efficiency by oxygenating both preexisting and treatment-induced cell hypoxia.

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Photodynamic Therapy
Dougherty, T. J., Gomer, C. J., Henderson, B. W., Jori, G., Kessel, D., Korbelik, M., Moan, J., & Peng, Q. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.12.889 · Cited by 4,716
Photodynamic Therapy
Gomer, C. J. (1988) · Cited by 4,169
Oxygen Consumption and Diffusion Effects in Photodynamic Therapy
Foster, T. H., Murant, R. S., Bryant, R. G., Knox, R. S., Gibson, S. L., & Hilf, R. (1991) · Radiation Research · doi:10.2307/3577919 · Cited by 400
Effects of low-energy laser irradiation on bone remodeling during experimental tooth movement in rats
Kawasaki, K., & Shimizu, N. (2000) · Lasers in Surgery and Medicine · doi:10.1002/(sici)1096-9101(2000)26:3 · Cited by 367
Relationship of tumor hypoxia and response to photodynamic treatment in an experimental mouse tumor.
Henderson, B. W., & Fingar, V. H. (1987) · PubMed · Cited by 339
Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents
Braun, R. D., Lanzen, J. L., Snyder, S. A., & Dewhirst, M. W. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2533 · Cited by 285
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy.
Koukourakis, M. I., Giatromanolaki, A. N., Skarlatos, J., Corti, L., Blandamura, S., Piazza, M., Gatter, K. C., & Harris, A. L. (2001) · PubMed · Cited by 271
Reduction of tumour oxygenation during and after photodynamic therapy in vivo: effects of fluence rate
Sitnik, T., Hampton, J., & Henderson, B. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.231 · Cited by 260
Tumor tissue oxygenation as evaluated by computerized-po2-histography
Kallinowski, F., Zander, R., Hoeckel, M., & Vaupel, P. W. (1990) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(90)90018-f · Cited by 256
Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma.
Ferrario, A., von Tiehl, K., Rucker, N., Schwarz, M. A., Gill, P. S., & Gomer, C. J. (2000) · PubMed · Cited by 253
Photofrin photodynamic therapy can significantly deplete or preserve oxygenation in human basal cell carcinomas during treatment, depending on fluence rate.
Henderson, B. W., Busch, T. M., Vaughan, L. A., Frawley, N. P., Babich, D., Sosa, T. A., Zollo, J. D., Dee, A. S., Cooper, M. T., Bellnier, D. A., et al. (2000) · PubMed · Cited by 248
Oxygen dependence of the photosensitizing effect of hematoporphyrin derivative in NHIK 3025 cells.
Moan, J. E., & Sommer, S. (1985) · PubMed · Cited by 225
Photodynamic therapy in oncology
Kinsella, T. J., Colussi, V., Oleinick, N. L., & Sibata, C. H. (2001) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2.6.917 · Cited by 218
In vivo TUMOR OXYGEN TENSION MEASUREMENTS FOR THE EVALUATION OF THE EFFICIENCY OF PHOTODYNAMIC THERAPY
Tromberg, B. J., Orenstein, A., Kimel, S., Barker, S. J., Hyatt, J., Nelson, J. S., & Berns, M. W. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb04193.x · Cited by 212
Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma.
Pal, S., Datta, K., & Mukhopadhyay, D. (2001) · PubMed · Cited by 196
Proliferation and hypoxia in human squamous cell carcinoma of the cervix: First report of combined immunohistochemical assays
Kennedy, A. S., Raleigh, J. A., Perez, G. M., Calkins, D. P., Thrall, D. Ε., Novotny, D. B., & Varia, M. A. (1997) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(96)00539-1 · Cited by 190
Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix
Watson, E. R., Hainan, K. E., Dische, S., Saunders, M. I., Cade, I. S., McEwen, J. B., Wiernik, G., Perrins, D. J. D., & Sutherland, I. (1978) · British Journal of Radiology · doi:10.1259/0007-1285-51-611-879 · Cited by 187
Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the bladder
Cade, I. S., McEwen, J. B., Dische, S., Saunders, M. I., Watson, E. R., Halnan, K. E., Wiernik, G., Perrins, D. J. D., & Sutherland, I. (1978) · British Journal of Radiology · doi:10.1259/0007-1285-51-611-876 · Cited by 182
The Role of Oxygen in Cutaneous Photodynamic Therapy
Fuchs, J., & Thiele, J. J. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00370-5 · Cited by 178
[NO TITLE AVAILABLE]
Sibata, C. H., Colussi, V., Oleinick, N. L., & Kinsella, T. J. (2000) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2000000800002 · Cited by 174
Photodynamic Therapy in the Treatment of Cancer
Hsi, R. A., Rosenthal, D. I., & GLATSTEIN, E. J. (1999) · Drugs · doi:10.2165/00003495-199957050-00005 · Cited by 170
Carcinoma of the cervix—anaemia, radiotherapy and hyperbaric oxygen
Dische, S., Anderson, P. J., Sealy, R., & Watson, E. R. (1983) · British Journal of Radiology · doi:10.1259/0007-1285-56-664-251 · Cited by 167
Fluence rate effects in photodynamic therapy of multicell tumor spheroids.
Foster, T. H., Hartley, D. F., Nichols, M. G., & Hilf, R. (1993) · PubMed · Cited by 157
ROLE OF ANTIBIOTICS IN INFLAMMATORY DISC LESIONS IN CHILDREN
Taylor, T. K., & Bye, W. A. (1977) · The Lancet · doi:10.1016/s0140-6736(77)90823-6 · Cited by 143
OXYGEN LIMITATION OF DIRECT TUMOR CELL KILL DURING PHOTODYNAMIC TREATMENT OF A MURINE TUMOR MODEL
Henderson, B. W., & Fingar, V. H. (1989) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1989.tb04110.x · Cited by 137
Depletion of tumor oxygenation during photodynamic therapy: detection by the hypoxia marker EF3 [2-(2-nitroimidazol-1[H]-yl)-N-(3,3,3-trifluoropropyl)acetamide ].
Busch, T. M., Hahn, S. M., Evans, S. M., & Koch, C. J. (2000) · PubMed · Cited by 112
Oxygen monitoring during 5-aminolaevulinic acid induced photodynamic therapy in normal rat colon
Curnow, A., Haller, J. C., & Bown, S. G. (2000) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(00)00120-2 · Cited by 110
Photochemotherapy in the Treatment of Cancer
Via, L. D., & Magno, S. M. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013372076 · Cited by 110
Enhancement of photodynamic therapy with 5-aminolaevulinic acid-induced porphyrin photosensitisation in normal rat colon by threshold and light fractionation studies
Messmann, H., Mlkvý, P., Buonaccorsi, G. A., Davies, C. L., MacRobert, A. J., & Bown, S. G. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.378 · Cited by 109
The effect of photodynamic therapy on the microcirculation
Reed, M., Miller, F. N., Wieman, T. J., Tseng, M. T., & Pietsch, C. G. (1988) · Journal of Surgical Research · doi:10.1016/0022-4804(88)90195-3 · Cited by 100
Effects of radiotherapy after hyperbaric oxygenation on malignant gliomas
Kohshi, K., Kinoshita, Y., Imada, H., Kunugita, N., Abe, H., Terashima, H., Tokui, N., & Uemura, S. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690345 · Cited by 84
Light Dose Fractionation to Enhance Photodynamic Therapy Using 5-Aminolevulinic Acid in the Normal Rat Colon
Curnow, A., Mcllroy, B. W., Postle‐Hacon, M. J., MacRobert, A. J., & Bown, S. G. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb05308.x · Cited by 84
Topical photodynamic therapy at low fluence rates – theory and practice
Langmack, K. A., Mehta, R. K., Twyman, P., & Norris, P. G. (2001) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(01)00116-6 · Cited by 75
Triplet excited states and semiquinone radicals of 1,4-disubstituted anthraquinones
Palit, D. K., Pal, H., Mukherjee, T., & Mittal, J. P. (1990) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/1010-6030(90)85017-q · Cited by 75
Analysis of the Heterogeneity of pO2 Dynamics During Photodynamic Therapy with Verteporfin¶
Pogue, B. W., Braun, R. D., Lanzen, J. L., Erickson, C., & Dewhirst, M. W. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0740700aothop2.0.co2 · Cited by 72
Temporal changes in pO2 of R3230Ac tumors in fischer-344 rats
Dewhirst, M. W., Braun, R. D., & Lanzen, J. L. (1998) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(98)00304-6 · Cited by 71
Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model
Walenta, S., Snyder, S. A., Haroon, Z. A., Braun, R. D., Amin, K., Brizel, D. M., Mueller‐Klieser, W., Chance, B., & Dewhirst, M. W. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(01)01700-x · Cited by 69
Modulation of tumor oxygenation
Vaupel, P. W., Kelleher, D. K., & Thews, O. (1998) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(98)00324-1 · Cited by 69
Feasibility of Detecting Hypoxia in Experimental Mouse Tumours with18F-fluorinated Tracers and Positron Emission Tomography: A Study Evaluating [18F]Fluoromisonidazole and [18F]Fluoro-2-deoxy-D-glucose
Bentzen, L. (2000) · Acta Oncologica · doi:10.1080/028418600750013320 · Cited by 67
Implications of a pre-existing tumor hypoxic fraction on photodynamic therapy
Fingar, V. H., Wieman, T. J., Park, Y. J., & Henderson, B. W. (1992) · Journal of Surgical Research · doi:10.1016/0022-4804(92)90101-5 · Cited by 60
Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma: hyperbaric oxygen, misonidazole, and accelerated radiotherapy, carbogen, and nicotinamide.
Hoskin, P., Saunders, M. I., & Dische, S. (1999) · PubMed · Cited by 59
Combined photodynamic therapy and hyperbaric oxygenation in carcinoma of the esophagus and the esophago-gastric junction✩
Maier, A., Tomaselli, F., Anegg, U., Rehak, P., Fell, B., Luznik, S., Pinter, H., & Smolle-Jüttner, F. M. (2000) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(00)00592-3 · Cited by 54
Tumor Oxygenation Changes Post‐Photodynamic Therapy
Chen, Q., Chen, H., & Hetzel, F. W. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb03003.x · Cited by 53
Self-citation
Measurement of PDT-induced hypoxia in Dunning prostate tumors by iodine-123-iodoazomycin arabinoside.
Moore, R. B., Chapman, J. D., Mercer, J., Mannan, R. H., Wiebe, L. I., McEwan, A. J. B., & McPhee, M. S. (1993) · PubMed · Cited by 51
Determination of rate constants of 1O2 consumption by 1O2 acceptors in weakly deactivating solvents
Opriel, U., Seikel, K., Schmidt, R., & Brauer, H. ‐. (1989) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/1010-6030(89)87128-x · Cited by 47
Enhanced Effectiveness of Photodynamic Therapy with Laser Light Fractionation in Patients with Esophageal Cancer
Messmann, H., Szeimies, R. M., Bäumler, W., Knüchel, R., Zirngibl, H., Schölmerich, J., & Holstege, A. (1997) · Endoscopy · doi:10.1055/s-2007-1004189 · Cited by 47
Tumor hypoxia and anemia: Impact on the efficacy of radiation therapy
Kumar, P. (2000) · Seminars in Hematology · doi:10.1016/s0037-1963(00)90061-1 · Cited by 43
Carcinoma of the cervix and the use of hyperbaric oxygen with radiotherapy: a report of a randomised controlled trial
Dische, S., Saunders, M. I., Sealy, R., Werner, I. D., Verma, N., Foy, C. J. W., & Bentzen, S. M. (1999) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(99)00124-3 · Cited by 43
Spatial measurement of oxygen levels during photodynamic therapy using time-resolved optical spectroscopy
Mcllroy, B. W., Curnow, A., Buonaccorsi, G. A., Scott, M. L. J., Bown, S. G., & MacRobert, A. J. (1998) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(98)00081-5 · Cited by 42
Measurement of oxygen tension in tumours by time-resolved fluorescence.
Young, W. K., Vojnovic, B., & Wardman, P. (1996) · PubMed · Cited by 40
Mathematical modelling of oxygen supply and oxygenation in tumor tissues: Prognostic, therapeutic, and experimental implications
Degner, F. L., & Sutherland, R. M. (1988) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(98)90021-9 · Cited by 40
Acute effects of combined photodynamic therapy and hyperbaric oxygenation in lung cancer—A clinical pilot study
Tomaselli, F., Maier, A., Sankin, O., Anegg, U., Stranzl, U., Pinter, H., Kapp, K. S., & Smolle‐Jüttner, F. M. (2001) · Lasers in Surgery and Medicine · doi:10.1002/lsm.1067 · Cited by 40
Sequencing of Combined Hyperthermia and Photodynamic Therapy
Chen, Q., Chen, H., Shapiro, H., & Hetzel, F. W. (1996) · Radiation Research · doi:10.2307/3579459 · Cited by 39
Self-citation
Nuclear Magnetic Resonance Spectroscopy and Sensitizer-Adduct Measurements of Photodynamic Therapy-Induced Ischemia in Solid Tumors
Chapman, J. D., McPhee, M. S., Walz, N., CHETNER, M. P., Stobbe, C. C., Soderlind, K. J., Arnfield, M. R., Meeker, B. E., Trimble, L. A., & Allen, P. S. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.22.1650 · Cited by 38
Pentoxifylline improves the oxygenation and radiation response of BA1112 rat rhabdomyosarcomas and EMT6 mouse mammary carcinomas
Collingridge, D. R., & Rockwell, S. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20001020)90:5 · Cited by 37
Photodynamic therapy enhanced by hyperbaric oxygen in acute endoluminal palliation of malignant bronchial stenosis (Clinical pilot study in 40 patients)
Tomaselli, F. (2001) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(01)00635-2 · Cited by 37
Does Hyperbaric Oxygen Enhance the Effect of Photodynamic Therapy in Patients with Advanced Esophageal Carcinoma? A Clinical Pilot Study
Maier, A., Anegg, U., Tomaselli, F., Rehak, P., Sankin, O., Fell, B., Renner, H., Pinter, H., Smolle-Jüttner, F.-M., & Friehs, G. B. (2002) · Endoscopy · doi:10.1055/s-2000-132 · Cited by 36
Radiation therapy with hyperbaric oxygen at 4 atmospheres pressure in the management of squamous cell carcinoma of the head and neck: results of a randomized clinical trial.
Haffty, B., Hurley, R. A., & Peters, L. J. (1999) · PubMed · Cited by 35
Expression of vascular endothelial growth factor in mouse tumours subjected to photodynamic therapy
Uehara, M., Inokuchi, T., Sano, K., & ZuoLin, W. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00243-x · Cited by 35
Hyperbaric oxygen therapy
Coles, C., Williams, M., Burnet, N. G., Trytko, B., Bennett, M. R., Leach, R., & Wilmshurst, P. T. (1999) · BMJ · doi:10.1136/bmj.318.7190.1076c · Cited by 34
Hyperbaric Oxygen Improves Tumor Radiation Response Significantly More Than Carbogen/Nicotinamide
Brizel, D. M., Hage, W. D., Dodge, R. K., Munley, M. T., Piantadosi, C. A., & Dewhirst, M. W. (1997) · Radiation Research · doi:10.2307/3579485 · Cited by 31
Improved Tumour Oxygenation and Radiosensitization by Combination with Nicotinamide and Pentoxifylline
Lee, I., Levitt, S. H., & Song, C. W. (1993) · International Journal of Radiation Biology · doi:10.1080/09553009314551351 · Cited by 29
Radiotherapy after hyperbaric oxygenation improves radioresponse in experimental tumor models
Kunugita, N., Kohshi, K., Kinoshita, Y., Katoh, T., Abe, H., Tosaki, T., Kawamoto, T., & Norimura, T. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00721-7 · Cited by 26
Effects of hyperbaric oxygen and normobaric carbogen on the radiation response of the rat rhabdomyosarcoma R1H 1 1This work was partially financed by the German Cancer Aid and the Fonds Ophthalmopathy, AMC Amsterdam, The Netherlands.
Hartmann, K. A., van der Kleij, A. J., Carl, U. M., Hulshof, M. C. C. M., Willers, R., & Sminia, P. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(01)01712-6 · Cited by 25
Fractionated Illumination for Oesophageal ALA-PDT: Effect on Blood Flow and PpIX Formation
van den Boogert, J., van Staveren, H. J., de Bruin, R. W. F., Siersema, P. D., & van Hillegersberg, R. (2001) · Lasers in Medical Science · doi:10.1007/pl00011331 · Cited by 24
The leeds results for radiotherapy in HBO for carcinoma of the head and neck
Berry, G., Dixon, B., & Ward, A. (1979) · Clinical Radiology · doi:10.1016/s0009-9260(79)80207-x · Cited by 23
Enhanced cell death in NR-S1 tumor by photodynamic therapy: Possible involvement of Fas and Fas ligand system
Yokota, T., Ikeda, H., Inokuchi, T., Sano, K., & Koji, T. (2000) · Lasers in Surgery and Medicine · doi:10.1002/1096-9101(2000)26:5 · Cited by 19
Oxygenation of human tumors—implications for combined therapy
Feldmann, H. J. (2001) · Lung Cancer · doi:10.1016/s0169-5002(01)00306-3 · Cited by 18
Shielding effects and hypoxia in photodynamic therapy
Herzog, M., Moser, J. G., Wagner, B., & Broecker, J. (1994) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/s0901-5027(05)80031-1 · Cited by 16
Magnetic resonance spectroscopic studies on 'real-time' changes in RIF-1 tumour metabolism and blood flow during and after photodynamic therapy
Bremner, J. C. M., Bradley, J., Stratford, I. J., & Adams, G. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.212 · Cited by 11
RADIOTHERAPY AND HYPERBARIC OXYGEN
Atkinson, L. (1979) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1979.tb112077.x · Cited by 10
PO2 in irradiated versus nonirradiated tumors of mice breathing oxygen at normal and elevated pressure
Gerweck, L. E., & Hetzel, F. W. (1995) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(94)00609-o · Cited by 9
Self-citation
Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma: hyperbaric oxygen, misonidazole, and accelerated radiotherapy, carbogen and nicotinamide.
Mj, D. (2000) · PubMed · Cited by 9
Modifications In Intratumor Microenvironment With PDT
Hetzel, F. W., & Chopp, M. (1989) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.978002 · Cited by 6
Self-citation
PRINCIPLES OF ONCOLOGY AND IMMUNOLOGY, AND TUMORS OF BLADDER, PENIS AND URETHRA
Droller, M. J. (2000) · The Journal of Urology · doi:10.1016/s0022-5347(05)67953-0 · Cited by 5
Is Hyperbaric Oxygen More Effective than Carbogen/Nicotinamide in Tumor Radiation Response?
Hartmann, K. A., van der Kleij, A. J., Schneider, C. J., & Sminia, P. (1997) · Radiation Research · doi:10.2307/3579327 · Cited by 2

Research works printed but not linked: 2

Nias, 1991, New Developments in Fundamental and Applied Radiobiology, 318
Tubiana, 1990, Introduction to Radiobiology

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Authors: Chen, Q., Huang, Z., Chen, H., Shapiro, H., Beckers, J., & Hetzel, F. W.
Affiliations: HealthONE (US)
ORCID: Chen, Qun
Huang, Zheng
Chen, Hua
Shapiro, Howard
Venue: Photochemistry and Photobiology
Publisher: American Society for Photobiology
Published: 2007-05-01
Volume: 76
Issue: 2
Pages: 197-203
ISSN: 0031-8655 (ISSN-L)
DOI: 10.1562/0031-8655(2002)0760197iotrbm2.0.co2
OpenAlex: W1958679672
Cited by: 124
References: 82
Citations by year: 2025: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 4 · 2013: 5 · 2012: 5
FWCI: 3.31
Type: journal article
Language: en
Open access: closed
Locations: Photochemistry and Photobiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P01CA043892)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: photodynamic therapy, tumor hypoxia, tumor oxygenation, hyperbaric oxygen therapy, normobaric oxygen, hyperoxygenation, reactive oxygen species, Photofrin, breast cancer
MeSH terms: Animals, Female, Male, Mammary Neoplasms, Experimental, Mice, Inbred C3H, Oxygen, Photochemotherapy, Photobiology, Mice

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Improvement of Tumor Response by Manipulation of Tumor Oxygenation During Photodynamic Therapy¶

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