ADHD, lead exposure and prevention: how much lead or how much evidence is needed?
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Despite its well-documented and much touted high heritability, the environmental causes of attention-deficit/hyperactivity disorder (ADHD) are a growing concern on the US research agenda [1,2]. One...
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Organophosphate pesticides, polychlorinated biphenyls, and lead may damage the neural systems implicated in ADHD.
“In particular, organophosphate pesticides, polychlorinated biphenyls, and lead may damage the neural systems implicated in ADHD (Nigg, 2008; Chang et al., 2018).”
From A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) (2019) · cites this paper as Nigg, 2008
In the main text (page not supplied), Nigg says polychlorinated biphenyls and lead appear to attack neural systems involved in ADHD. The paper mentions pesticides as potentially neurotoxic exposures, but does not identify organophosphate pesticides or make that specific neural-systems claim about them. (LLM, conf=0.86)
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“In particular, organophosphate pesticides, polychlorinated biphenyls, and lead may damage the neural systems implicated in ADHD (Nigg, 2008; Chang et al., 2018).”
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- Authors
- Nigg, J. T.
- Affiliations
- Michigan State University (US)
- Corresponding author
- Nigg, Joel T
- ORCID
- Nigg, Joel T
- Venue
- Expert Review of Neurotherapeutics
- Publisher
- Informa UK Limited
- Published
- 2008-04
- Volume
- 8
- Issue
- 4
- Pages
- 519-521
- ISSN
- 1473-7175 (ISSN-L)
- 1744-8360
- OpenAlex
- W2142239173
- Cited by
- 28
- References
- 18
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Review of Neurotherapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01-MH70004, R01MH070004, R01MH059105)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- attention deficit hyperactivity disorder, lead exposure, environmental risk factors, ADHD prevention, heritability
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Environmental Exposure, Humans, Risk Factors, Comorbidity, Prevalence, Risk Assessment, Evidence-Based Medicine, Lead Poisoning, Nervous System
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