On the pathway to better birth outcomes? A systematic review of azithromycin and curable sexually transmitted infections.
Open accessAbstract
The WHO recommends the administration of sulfadoxine-pyrimethamine (SP) to all pregnant women living in areas of moderate (stable) to high malaria transmission during scheduled antenatal visits, beginning in the second trimester and continuing to delivery. Malaria parasites have lost sensitivity to SP in many endemic areas, prompting the investigation of alternatives that include azithromycin-based combination (ABC) therapies. Use of ABC therapies may also confer protection against curable sexually transmitted infections and reproductive tract infections (STIs/RTIs). The magnitude of protection at the population level would depend on the efficacy of the azithromycin-based regimen used and the underlying prevalence of curable STIs/RTIs among pregnant women who receive preventive treatment. This systematic review summarizes the efficacy data of azithromycin against curable STIs/RTIs.
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Syphilis more than any other bacterial and curable sexually transmitted infection has greater potential to cause adverse birth outcomes when the diagnosis is missed.
“Syphilis more than any other bacterial and curable sexually transmitted infection, has greater potential to cause adverse birth outcomes when the diagnosis is missed 3.”
From Audit of antenatal screening for syphilis and HIV in migrant and refugee women on the Thai-Myanmar border: a descriptive study (2015) · cites this paper as [3]
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Sorted by citations
Unger, H. W., Ome-Kaius, M., Wangnapi, R. A., Umbers, A. J., Hanieh, S., Suen, C. S. L. W., Robinson, L. J., Rosanas-Urgell, A., Wapling, J., Lufele, E., et al. (2015) · BMC Medicine · doi:10.1186/s12916-014-0258-3 · Cited by 102 · see citing works
Chico, R. M., Cano, J., Ariti, C., Collier, T. J., Chandramohan, D., Roper, C., & Greenwood, B. (2015) · Tropical Medicine & International Health · doi:10.1111/tmi.12595 · Cited by 77 · see citing works
Self-citationChico, R. M., Chaponda, E. B., Ariti, C., & Chandramohan, D. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix026 · Cited by 68 · see citing works
Self-citationMcGready, R., Kang, J., Watts, I., Tyrosvoutis, M. E. G., Torchinsky, M. B., Htut, A. M., Tun, N. W., Keereecharoen, L., Wangsing, C., Hanboonkunupakarn, B., et al. (2015) · F1000Research · doi:10.12688/f1000research.4190.2 · Cited by 19 · see citing works
- Authors
- Chico, R. M., Hack, B. B., Newport, M. J., Ngulube, E., & Chandramohan, D.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- Brighton and Sussex Medical School (GB)
- Corresponding author
- Chico, R Matthew
- Venue
- Expert Review of Anti-infective Therapy
- Publisher
- Informa UK Limited
- Published
- 2013-12
- Volume
- 11
- Issue
- 12
- Pages
- 1303-1332
- ISSN
- 1478-7210 (ISSN-L)
- 1744-8336
- PMC
- PMC3906303
- OpenAlex
- W1980391945
- Cited by
- 23
- References
- 199
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 4 · 2015: 10
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Review of Anti-infective Therapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Funders
- Wellcome Trust (100715)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Keywords
- azithromycin, reproductive tract infections, sulfadoxine-pyrimethamine, malaria in pregnancy, antenatal prophylaxis, birth outcomes
- MeSH terms
- Adult, Anti-Bacterial Agents, Clinical Trials as Topic, Drug Combinations, Female, Humans, Male, Pregnancy, Pregnancy Outcome, Pyrimethamine, Sexually Transmitted Diseases, Sulfadoxine, Vaginosis, Bacterial, Malaria, Falciparum, Treatment Outcome, Azithromycin, Drug Resistance, Bacterial, Reproductive Tract Infections
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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