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Cited by 150Prenatal Substance Exposure EffectsPregnancy and preeclampsia studiesSmoking Behavior and Cessation

Effects of maternal tobacco-smoke exposure on fetal growth and neonatal size

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Reeves, Shane, Bernstein, Ira·2008·Expert Review of Obstetrics & Gynecology
DOI 10.1586/17474108.3.6.719PMC PMC2770192
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Abstract

Exposure to tobacco smoke, through both active and passive measures, has a significant impact on women's health, including effects on the cardiovascular, pulmonary and reproductive systems. Of particular interest is the effect of smoking on pregnancy outcomes. One crucial outcome that has been linked to the subsequent development of both neonatal and adult disease is intrauterine or fetal growth restriction. In this article, we will summarize the effects of smoking on newborn size and fetal growth. We will review evidence showing that tobacco consumption during pregnancy leads to a reduction in birthweight, largely through affecting specific anthropometric measures and newborn body composition. We will highlight the role of genetic susceptibility to these effects and discuss how smoking cessation prior to the third trimester results in a reduction in the risk of fetal growth restriction.

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  • Women who quit smoking in the first trimester have similar odds of developing SGA compared to non-smokers.

    “we found that women who quit smoking in the first trimester did have similar odds of developing SGA compared to non-smokers, as previous studies have also suggested [40, 41, 43].”

    From Associations between periconceptional lifestyle behaviours and adverse pregnancy outcomes (2021) · cites this paper as [41]

    The Smoking cessation during pregnancy section says that stopping in the first trimester produces infants with anthropometric measures similar to those of women who never smoked. It also reports no increased risk of low birthweight among women who quit by the third trimester. Neither passage establishes similar odds of SGA specifically for first-trimester quitters and nonsmokers. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Smoking is associated with a higher odds of sPTB and birth of SGA neonates.

    “In accordance with previous studies, we indeed found that smoking is associated with a higher odds of sPTB and birth of SGA neonates [38–41].”

    From Associations between periconceptional lifestyle behaviours and adverse pregnancy outcomes (2021) · cites this paper as [41]

    The Abstract (page unavailable) reports higher odds of preterm delivery before 37 weeks among heavy smokers, but does not specify spontaneous preterm birth (sPTB). The Smoking & birthweight section (page unavailable) reports an association between maternal smoking and SGA neonates. Thus, the SGA finding is supported, while the spontaneous qualifier for preterm birth is not established by this paper. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Reeves, S., & Bernstein, I.
Affiliations
University of Vermont (US)
Corresponding author
Bernstein, Ira
ORCID
Venue
Expert Review of Obstetrics & Gynecology
Publisher
Informa UK Limited
Published
2008-11
Volume
3
Issue
6
Pages
719-730
ISSN
  • 1747-4108 (ISSN-L)
  • 1747-4116
DOI
10.1586/17474108.3.6.719
PMC
PMC2770192
OpenAlex
W2089955483
Cited by
150
References
4
Citations by year
2026: 5 · 2025: 11 · 2024: 11 · 2023: 6 · 2022: 14 · 2021: 8 · 2020: 16 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 11 · 2015: 3 · 2014: 6 · 2013: 11 · 2012: 8
FWCI
4.51
Type
journal article
Language
en
Open access
Locations
  • Expert Review of Obstetrics & Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (R01DA014028)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords
maternal smoking, tobacco smoke exposure, fetal growth restriction, birth weight, neonatal size, anthropometric measures, genetic susceptibility, smoking cessation, pregnancy outcomes, passive smoking

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