The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Immune interactions in endometriosis
Open accessAbstract
Endometriosis is a common, complex gynecologic disorder characterized by the presence of endometrial glands and stroma at extrauterine (ectopic) sites. In women who develop this disease, alterations in specific biological processes involving both the endocrine and immune systems have been observed, which may explain the survival and growth of displaced endometrial tissue in affected women. In the past decade, a considerable amount of research has implicated a role for alterations in progesterone action at both eutopic and ectopic sites of endometrial growth which may contribute to the excessive inflammation associated with progression of endometriosis; however, it remains unclear whether these anomalies induce the condition or are simply a consequence of the disease process. In this article, we summarize current knowledge of alterations within the immune system of endometriosis patients and discuss how endometrial cells from women with this disease not only have the capacity to escape immunosurveillance, but also use inflammatory mechanisms to promote their growth within the peritoneal cavity. Finally, we discuss evidence that exposure to an environmental endocrine disruptor, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, can mediate the development of an endometrial phenotype that exhibits both reduced progesterone responsiveness and hypersensitivity to proinflammatory stimuli mimicking the endometriosis phenotype. Future studies in women with endometriosis should consider whether a heightened inflammatory response within the peritoneal microenvironment contributes to the development and persistence of this disease.
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Cites
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Immunobiology of endometriosis
Lebovic, D. I., Mueller, M. D., & Taylor, R. N. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01630-7 · Cited by 857
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“A potential role for exposure to environmental toxicants capable of both endocrine and immune disruption in the development of endometriosis first emerged with the observation of increased incidence and severity of this disease in a primate colony following chronic dietary exposure to 2,3,7,8-tetrachlorodibenzo-p-diox…”
BackgroundOosterlynck, D. J., Cornillie, F. J., Waer, M., Vandeputte, M., & Koninckx, P. R. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54414-8 · Cited by 441 · cited 1×
“Specifically, NK cells from women with endometriosis display an increased expression of killer inhibitory receptor, which interacts with HLA class I molecules on potential target cells to suppress NK cell activity [70].”
BackgroundStem Cells and the Pathogenesis of Endometriosis
Sasson, I. E., & Taylor, H. S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1434.014 · Cited by 371
Steroid receptor expression in uterine natural killer cells
Henderson, T. A., Saunders, P. T. K., Moffett-King, A., Groome, N. P., & Critchley, H. O. D. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021174 · Cited by 283
Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis
Rana, N., Braun, D. P., House, R., Gebel, H., Rotman, C., & Dmowski, W. P. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58262-4 · Cited by 264 · cited 1×
“Specifically, a decrease in NK cell cytotoxicity [41,42] and an enhanced activation state of monocytes and peritoneal macrophages has been documented in endometriosis patients [43–45].”
BackgroundThe natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis
Oosterlynck, D. J., Meuleman, C., Waer, M., Vandeputte, M., & Koninckx, P. R. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55224-8 · Cited by 242
Cited by
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
In vitro models for liver toxicity testing
Soldatow, V. Y., LeCluyse, E. L., Griffith, L. G., & Rusyn, I. (2013) · Toxicol. Res. · doi:10.1039/c2tx20051a · Cited by 472
Endometriosis: a high-risk population for major chronic diseases?
Kvaskoff, M., Mu, F., Terry, K. L., Harris, H. R., Poole, E. M., Farland, L., & Missmer, S. A. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv013 · Cited by 439
The disparate origins of ovarian cancers: pathogenesis and prevention strategies
Karnezis, A. N., Cho, K. R., Gilks, C. B., Pearce, C. L., & Huntsman, D. G. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.113 · Cited by 300
Peripheral changes in endometriosis-associated pain
Morotti, M., Vincent, K., Brawn, J., Zondervan, K. T., & Becker, C. M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu021 · Cited by 198
Metadata
- Authors
- Herington, J. L., Bruner-Tran, K. L., Lucas, J. A., & Osteen, K. G.
- Venue
- Expert Review of Clinical Immunology
- Publisher
- Informa UK Limited
- Published
- 2011-09
- Volume
- 7
- Issue
- 5
- Pages
- 611-626
- ISSN
- 1744-666X (ISSN-L)
- 1744-8409
- OpenAlex
- W2004717157
- Cited by
- 228
- References
- 20
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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