Stem Cells and the Pathogenesis of Endometriosis

Sasson, Isaac E.; Taylor, Hugh S.

doi:10.1196/annals.1434.014

Cited by 371Endometriosis Research and TreatmentGynecological conditions and treatmentsEctopic Pregnancy Diagnosis and Management

Stem Cells and the Pathogenesis of Endometriosis

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Sasson, Isaac E., Taylor, Hugh S.·2008·Annals of the New York Academy of Sciences

DOI 10.1196/annals.1434.014PMC PMC3107843

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Abstract

Endometriosis is a common gynecological disorder that is defined by the presence of endometrial tissue outside the uterine cavity. This disease often results in extensive morbidity, including chronic pelvic pain and infertility. The pathogenesis of endometriosis is likely multifactorial, and extensive investigation has explored the role of genetics, environmental factors, and the immune system in predisposing patients to developing endometriosis. A series of recent publications have described the identification of endometrial stem/progenitor cells. Such cells have long been speculated to function in the cyclic regeneration of the endometrium during the menstrual cycle and in the pathogenesis of several gynecological disorders. This narrative review will (i) examine the evidence for endometrial stem cells, (ii) examine their potential role in the pathogenesis of endometriosis, and (iii) identify important unanswered questions with suggestions for future investigation.

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Currently, there are no definitive markers to allow isolation and characterization of endometrial progenitor or stem cells, and it is unknown what drives the recruitment and homing of these cells to eutopic endometrium or ectopic sites.
“Currently, there are no definitive markers to allow isolation and characterization of endometrial progenitor or stem cells, and it is unknown what drives the recruitment and homing of these cells to eutopic endometrium or ectopic sites.107,108”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [108]

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Authors: Sasson, I. E., & Taylor, H. S.
Affiliations: Yale University (US)
Corresponding author: Taylor, Hugh S.
ORCID: Sasson, Isaac E.
Taylor, Hugh S.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2008-04
Volume: 1127
Issue: 1
Pages: 106-115
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1196/annals.1434.014
PMC: PMC3107843
OpenAlex: W2079224311
Cited by: 371
References: 115
Citations by year: 2026: 11 · 2025: 16 · 2024: 19 · 2023: 18 · 2022: 17 · 2021: 26 · 2020: 20 · 2019: 23 · 2018: 20 · 2017: 29 · 2016: 20 · 2015: 26 · 2014: 29 · 2013: 29 · 2012: 21
FWCI: 2.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 16 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD052668)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords: endometriosis, endometrial stem cells, stem/progenitor cells, endometriosis pathogenesis, endometrial regeneration, menstrual cycle, infertility, chronic pelvic pain, immune system, genetic susceptibility, environmental factors
MeSH terms: Bone Marrow Cells, Endometriosis, Endometrium, Female, Humans, Infertility, Female, Lymphatic Metastasis, Neoplasm Metastasis, Stem Cells, Uterine Diseases, Uterus

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Stem Cells and the Pathogenesis of Endometriosis

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