The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
Open accessAbstract
Pathological increases in cell death in the liver as well as in peripheral tissues has emerged as an important mechanism involved in the development and progression of nonalcoholic fatty liver disease (NAFLD). An increase in hepatocyte cell death by apoptosis is typically present in patients with NAFLD and in experimental models of steatohepatitis, while an increase in adipocyte cell death in visceral adipose tissue may be an important mechanism triggering insulin resistance and hepatic steatosis. The two fundamental pathways of apoptosis, the extrinsic (death receptor-mediated) and intrinsic (organelle-initiated) pathways, are both involved. This article summarizes the current knowledge related to the distinct molecular and biochemical pathways of cell death involved in NAFLD pathogenesis. In particular, it will highlight the efforts for the development of both novel diagnostic and therapeutic strategies based on this knowledge.
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Cites
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Cited by
Mechanisms of NAFLD development and therapeutic strategies
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Metadata
- Authors
- Alkhouri, N., Carter-Kent, C., & Feldstein, A. E.
- Venue
- Expert Review of Gastroenterology & Hepatology
- Publisher
- Informa UK Limited
- Published
- 2011-04
- Volume
- 5
- Issue
- 2
- Pages
- 201-212
- ISSN
- 1747-4124 (ISSN-L)
- 1747-4132
- OpenAlex
- W1993384072
- Cited by
- 254
- References
- 13
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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